Protein: SYFB
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)

Gene: SYFB, FARSB
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q9NSD9

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1449355

SYFA
Phenylalanine--tRNA ligase alpha subunit

10

8

Small-scale

0.975

High

355110

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

3

0

High-throughput

0.634

High

1331918

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

0

High-throughput

0.622

High

1449341

SYFB
Phenylalanine--tRNA ligase beta subunit

1

1

High-throughput

0.618

High

709019

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

243060

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

1447313

ANLN
Anillin

2

1

High-throughput

0.584

High

1449347

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

397032

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

541706

FGFR1
Fibroblast growth factor receptor 1

2

2

High-throughput

0.571

High

988750

RAC1
Ras-related C3 botulinum toxin substrate 1

2

3

High-throughput

0.571

High

1227536

A16L1
Autophagy-related protein 16-1

2

3

High-throughput

0.571

High

530437

TAU
Microtubule-associated protein tau

2

2

High-throughput

0.552

High

1144549

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

1327798

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

1391057

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

624159

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

2

High-throughput

0.536

High

927570

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

284476

HSBP1
Heat shock factor-binding protein 1

1

0

High-throughput

0.513

High

414703

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

466707

GLI1
Zinc finger protein GLI1

1

0

High-throughput

0.513

High

607718

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.513

High

908465

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

946463

MTPN
Myotrophin

1

0

High-throughput

0.513

High

1005651

PITX1
Pituitary homeobox 1

1

0

High-throughput

0.513

High

1244942

FOXR1
Forkhead box protein R1

1

0

High-throughput

0.513

High

1316302

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.513

High

1357215

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

1395774

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1449342

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

1449358

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

1449359

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

951869

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

1449348

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

844025

HD
Huntingtin

1

0

High-throughput

0.493

High

1397747

MAGBA
Melanoma-associated antigen B10

1

1

High-throughput

0.489

High

964473

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

401556

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

404463

GCR
Glucocorticoid receptor

1

3

High-throughput

0.479

High

412673

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

466484

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

537973

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

581317

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

607149

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

799504

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

831498

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

935179

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

962538

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

971152

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

978339

RHOB
Rho-related GTP-binding protein RhoB

1

4

High-throughput

0.479

High

1100434

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1107252

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1135825

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

1138677

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1155814

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1255725

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1271015

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

1280540

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1324085

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

1366894

RND1
Rho-related GTP-binding protein Rho6

1

5

High-throughput

0.479

High

1397470

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1407904

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1418464

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1418810

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

1432560

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

2

Small-scale

0.479

High

1434001

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1449353

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1449357

ARI1
E3 ubiquitin-protein ligase ARIH1

1

2

High-throughput

0.479

High

1148569

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.460

High

1449350

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

Small-scale

0.460

High

125629

LEG9
Galectin-9

1

0

High-throughput

0.458

High

316057

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

325126

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

565482

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

567494

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

582980

EZRI
Ezrin

1

0

High-throughput

0.458

High

623564

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

643091

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

766889

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

884403

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

888344

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

891819

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

974205

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.458

High

995844

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1029392

SET
Protein SET

1

0

High-throughput

0.458

High

1065771

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

1102663

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.458

High

1218995

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1247012

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1289654

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1290760

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1311980

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

1313461

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1335522

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.458

High

1364274

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1364615

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1417066

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1429207

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.458

High

1429858

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1449343

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1449344

EHD3
EH domain-containing protein 3

1

0

High-throughput

0.458

High

1449351

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

0

High-throughput

0.458

High

1449360

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.458

High

354786

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

430409

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

705569

GRN
Progranulin

1

1

High-throughput

0.445

High

1209704

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1449354

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

106711

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

260511

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

373259

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

589807

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696624

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

1249250

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1367379

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1396639

RHOV
Rho-related GTP-binding protein RhoV

1

4

High-throughput

0.437

High

1419422

RHBT2
Rho-related BTB domain-containing protein 2

1

3

High-throughput

0.437

High

838185

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

942914

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

1398372

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.426

High

330334

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

887255

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

1402867

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

619934

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.313

High

1314439

SLX4
Structure-specific endonuclease subunit SLX4

2

0

High-throughput

0.298

High

387903

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

389531

FINC
Fibronectin

1

0

High-throughput

0.279

Low

608362

EGLN
Endoglin

1

0

High-throughput

0.279

Low

662659

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.279

Low

932350

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

1385305

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.279

Low

1415879

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

1449346

GHRL
Appetite-regulating hormone

1

0

High-throughput

0.279

Low

378880

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

472355

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

769292

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879508

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1186147

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

1327222

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1348225

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1429363

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1449345

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

1449349

TEKT2
Tektin-2

1

0

High-throughput

0.249

Low

1449352

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1449356

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025