Protein: CD3Z
T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)

Gene: CD3Z, CD247
Organism: Homo sapiens
Interactions: 189
UniProt ID: P20963

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

596495

CD3Z
T-cell surface glycoprotein CD3 zeta chain

2

1

Small-scale

0.820

High

596514

ZAP70
Tyrosine-protein kinase ZAP-70

20

7

Small-scale

0.761

High

411592

LCK
Tyrosine-protein kinase Lck

5

2

Small-scale

0.711

High

596601

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

Small-scale

0.586

High

282182

NCTR1
Natural cytotoxicity triggering receptor 1

2

4

Small-scale

0.584

High

596502

SHC1
SHC-transforming protein 1

2

4

Small-scale

0.571

High

596517

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.569

High

596510

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.561

High

596521

JAK3
Tyrosine-protein kinase JAK3

1

9

Small-scale

0.561

High

596499

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

Small-scale

0.559

High

243130

SH21A
SH2 domain-containing protein 1A

1

6

Small-scale

0.554

High

358472

CO1A1
Collagen alpha-1(I) chain

1

0

High-throughput

0.513

High

596550

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.513

High

596597

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.513

High

441177

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

1

Small-scale

0.501

High

596512

CASP3
Caspase-3

1

1

Small-scale

0.501

High

596591

ATX2
Ataxin-2

1

0

High-throughput

0.493

High

486150

GRAB
Granzyme B

1

0

Small-scale

0.480

High

158902

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

Small-scale

0.479

High

412005

FYN
Tyrosine-protein kinase Fyn

1

2

Small-scale

0.479

High

557602

NCK1
SH2/SH3 adapter protein NCK1

1

3

Small-scale

0.479

High

596515

KSYK
Tyrosine-protein kinase SYK

1

6

Small-scale

0.479

High

596519

STA5B
Signal transducer and activator of transcription 5B

1

1

Small-scale

0.479

High

596544

SLAP1
Src-like-adapter

1

5

Small-scale

0.479

High

596585

SHC3
SHC-transforming protein 3

1

4

Small-scale

0.479

High

596596

SLAP2
Src-like-adapter 2

1

5

Small-scale

0.479

High

207425

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

430681

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

Small-scale

0.458

High

596496

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.458

High

596501

CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

1

0

Small-scale

0.458

High

596505

CCR7
C-C chemokine receptor type 7

1

0

Small-scale

0.458

High

596526

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

0

Small-scale

0.458

High

596535

TBA1B
Tubulin alpha-1B chain

1

0

Small-scale

0.458

High

596551

LY6E
Lymphocyte antigen 6E

1

0

Small-scale

0.458

High

596570

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

Small-scale

0.458

High

596586

DOCK2
Dedicator of cytokinesis protein 2

1

0

Small-scale

0.458

High

596599

CILK1
Serine/threonine-protein kinase ICK

1

0

Small-scale

0.458

High

596600

GAB2
GRB2-associated-binding protein 2

1

0

Small-scale

0.458

High

69510

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

2

High-throughput

0.445

High

70354

B2R643
Unconventional myosin-Ia

1

2

High-throughput

0.445

High

181585

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

High-throughput

0.445

High

596516

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.445

High

596518

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.445

High

596523

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

596536

TMF1
TATA element modulatory factor

1

1

High-throughput

0.445

High

596540

EWS
RNA-binding protein EWS

1

2

High-throughput

0.445

High

596578

Q7Z3N6
Unconventional myosin-Id

1

3

High-throughput

0.445

High

596592

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.445

High

596511

STA5A
Signal transducer and activator of transcription 5A

1

1

Small-scale

0.437

High

66325

A8K146
cDNA FLJ76216, highly similar to Homo sapiens xeroderma pigmentosum, complementation group C

1

0

High-throughput

0.426

High

66327

A8K1L8
Serine/arginine-rich splicing factor 1

1

0

High-throughput

0.426

High

66542

A8K651
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.426

High

70382

B2R7W4
cDNA, FLJ93632, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.426

High

70442

B2RBR9
cDNA, FLJ95650, highly similar to Homo sapiens karyopherin

1

0

High-throughput

0.426

High

70452

B2RCF3
Glycylpeptide N-tetradecanoyltransferase

1

0

High-throughput

0.426

High

70477

B2RDW1
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

72099

B3KNS7
Long-chain-fatty-acid--CoA ligase ACSBG1

1

0

High-throughput

0.426

High

72228

B3KTS5
Voltage-dependent anion-selective channel protein 1

1

0

High-throughput

0.426

High

72240

B3KTV0
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

78150

B5BUE6
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.426

High

81567

B7Z2W3
cDNA FLJ54432, highly similar to Alpha-actinin-1

1

0

High-throughput

0.426

High

87694

D0PNI1
14-3-3 protein zeta/delta

1

0

High-throughput

0.426

High

94589

F1T0L7
Anoctamin-2

1

0

High-throughput

0.426

High

117348

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.426

High

243292

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.426

High

260753

H2AY
Core histone macro-H2A.1

1

0

High-throughput

0.426

High

261200

FLNB
Filamin-B

1

0

High-throughput

0.426

High

280204

CBPD
Carboxypeptidase D

1

0

High-throughput

0.426

High

391326

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.426

High

397267

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.426

High

417931

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

437888

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.426

High

451190

TPM1
Tropomyosin alpha-1 chain

1

0

High-throughput

0.426

High

521664

ACE
Angiotensin-converting enzyme

1

0

High-throughput

0.426

High

596497

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.426

High

596503

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.426

High

596509

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.426

High

596522

BI1
Bax inhibitor 1

1

0

High-throughput

0.426

High

596524

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.426

High

596525

SIK1
Serine/threonine-protein kinase SIK1

1

0

High-throughput

0.426

High

596527

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.426

High

596528

H4
Histone H4

1

0

High-throughput

0.426

High

596529

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.426

High

596530

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.426

High

596531

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.426

High

596532

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.426

High

596533

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.426

High

596537

SKOR1
SKI family transcriptional corepressor 1

1

0

High-throughput

0.426

High

596538

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.426

High

596541

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.426

High

596542

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.426

High

596549

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.426

High

596553

Q2F834
Myosin regulatory light chain

1

0

High-throughput

0.426

High

596565

Q5U0I6
Ras-related protein Rab-1A

1

0

High-throughput

0.426

High

596568

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

0

High-throughput

0.426

High

596571

LARP1
La-related protein 1

1

0

High-throughput

0.426

High

596575

H2AV
Histone H2A.V

1

0

High-throughput

0.426

High

596576

Q7KYM9
ORF protein

1

0

High-throughput

0.426

High

596581

NLGN1
Neuroligin-1

1

0

High-throughput

0.426

High

596582

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.426

High

596588

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.426

High

596589

SPTCS
Spatacsin

1

0

High-throughput

0.426

High

596590

STRBP
Spermatid perinuclear RNA-binding protein

1

0

High-throughput

0.426

High

596604

MYH4
Myosin-4

1

0

High-throughput

0.426

High

49084

A0PJ87
RSL1D1 protein

1

1

High-throughput

0.407

High

59477

A3RJH1
ATP-dependent RNA helicase DDX1

1

1

High-throughput

0.407

High

59929

A4FU77
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

1

High-throughput

0.407

High

60122

A4QPB0
IQ motif containing GTPase activating protein 1

1

1

High-throughput

0.407

High

66463

A8K394
cDNA FLJ76708, highly similar to Homo sapiens nuclear mitotic apparatus protein 1

1

1

High-throughput

0.407

High

70349

B2R5W2
cDNA, FLJ92657, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein C

1

3

High-throughput

0.407

High

70367

B2R6K0
cDNA, FLJ92988, highly similar to Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2

1

1

High-throughput

0.407

High

70410

B2R935
Cell division control protein

1

1

High-throughput

0.407

High

71070

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.407

High

72792

B4DGR3
Vesicle-fusing ATPase

1

2

High-throughput

0.407

High

73295

B4E312
cDNA FLJ53422, highly similar to TATA-binding protein-associated factor 2N

1

1

High-throughput

0.407

High

81653

B7Z7U6
cDNA FLJ51769, highly similar to Ras GTPase-activating-like protein IQGAP2

1

1

High-throughput

0.407

High

81656

B7Z8W3
cDNA FLJ53272, highly similar to Homo sapiens LIM domain 7

1

1

High-throughput

0.407

High

550316

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.407

High

596520

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

High-throughput

0.407

High

596539

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.407

High

596543

Q0IIN5
VCP protein

1

1

High-throughput

0.407

High

596552

Q1JQ76
Ribosomal protein

1

1

High-throughput

0.407

High

596555

Q2M1Z1
MutL homolog 3

1

1

High-throughput

0.407

High

596558

Q4ZG72
ATP-dependent RNA helicase

1

1

High-throughput

0.407

High

596562

Q53GL6
RNA binding protein

1

3

High-throughput

0.407

High

596563

Q59FC6
Tumor rejection antigen

1

1

High-throughput

0.407

High

596572

ATAD2
ATPase family AAA domain-containing protein 2

1

1

High-throughput

0.407

High

596580

RALYL
RNA-binding Raly-like protein

1

3

High-throughput

0.407

High

596603

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

1

High-throughput

0.407

High

596545

U119A
Protein unc-119 homolog A

1

0

Small-scale

0.292

High

372994

VTNC
Vitronectin

1

0

High-throughput

0.282

High

596507

PCGF2
Polycomb group RING finger protein 2

1

0

High-throughput

0.282

High

596602

ZN281
Zinc finger protein 281

1

0

High-throughput

0.282

High

596598

CZIB
CXXC motif containing zinc binding protein

1

0

High-throughput

0.279

Low

596595

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

Small-scale

0.249

Low

57733

A2BDK6
Microtubule-associated protein 1B

1

0

High-throughput

0.232

Low

59668

A4D1I1
Similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1

1

0

High-throughput

0.232

Low

59673

A4D1N4
Coiled-coil-helix-coiled-coil-helix domain containing 3

1

0

High-throughput

0.232

Low

66555

A8K6V3
Splicing factor 3B subunit 3

1

0

High-throughput

0.232

Low

66596

A8K8A6
cDNA FLJ76931, highly similar to Homo sapiens testes-specific heterogenous nuclear ribonucleoprotein G-T, mRNA

1

0

High-throughput

0.232

Low

68509

IQAK1
IQ motif and ankyrin repeat domain-containing protein 1

1

0

High-throughput

0.232

Low

596564

Q5JR94
40S ribosomal protein S8

1

0

High-throughput

0.232

Low

596566

ERI6B
Glutamate-rich protein 6B

1

0

High-throughput

0.232

Low

596567

NSN5C
Putative methyltransferase NSUN5C

1

0

High-throughput

0.232

Low

596569

Q6IAX1
Squalene synthase

1

0

High-throughput

0.232

Low

596573

MPRIP
Myosin phosphatase Rho-interacting protein

1

0

High-throughput

0.232

Low

596574

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.232

Low

596577

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.232

Low

596579

Q7Z5A3
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.232

Low

596583

ZN439
Zinc finger protein 439

1

0

High-throughput

0.232

Low

596584

RTL9
Retrotransposon Gag-like protein 9

1

0

High-throughput

0.232

Low

596587

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.232

Low

596593

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.232

Low

596594

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.232

Low

70330

B2R4C1
Large ribosomal subunit protein eL31

1

0

High-throughput

0.232

Low

70369

B2R6K4
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

High-throughput

0.232

Low

70432

B2RAU8
cDNA, FLJ95131, highly similar to Homo sapiens nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.232

Low

70437

B2RBB2
cDNA, FLJ95416, highly similar to Homo sapiens phosphatidylinositol glycan, class S

1

0

High-throughput

0.232

Low

70453

B2RCI8
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.232

Low

72369

B3KW06
cDNA FLJ41848 fis, clone NT2RI3003382

1

0

High-throughput

0.232

Low

72391

B3KWX7
cDNA FLJ44170 fis, clone THYMU2035319, highly similar to RNA-binding region-containing protein 2

1

0

High-throughput

0.232

Low

72464

B4DDS7
Signal recognition particle 54 kDa protein

1

0

High-throughput

0.232

Low

72893

B4DLD4
cDNA FLJ56738, highly similar to Fibrillarin

1

0

High-throughput

0.232

Low

72934

B4DNQ8
cDNA FLJ57544, highly similar to Zinc finger protein 672

1

0

High-throughput

0.232

Low

72989

B4DSR6
cDNA FLJ52684, highly similar to Dynein heavy chain, cytosolic

1

0

High-throughput

0.232

Low

78144

B5BUB1
RuvB-like helicase

1

0

High-throughput

0.232

Low

92592

E9PM64
Dynein heavy chain domain 1

1

0

High-throughput

0.232

Low

99472

F5GX40
Protein kinase, DNA-activated, catalytic subunit

1

0

High-throughput

0.232

Low

124758

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.232

Low

135984

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.232

Low

303600

O95036
Large ribosomal subunit protein uL30

1

0

High-throughput

0.232

Low

314225

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.232

Low

596498

CALX
Calnexin

1

0

High-throughput

0.232

Low

596500

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.232

Low

596504

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.232

Low

596506

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.232

Low

596508

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.232

Low

596513

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.232

Low

596534

ACTS
Actin, alpha skeletal muscle

1

0

High-throughput

0.232

Low

596546

DNSL3
Deoxyribonuclease gamma

1

0

High-throughput

0.232

Low

596547

RCN2
Reticulocalbin-2

1

0

High-throughput

0.232

Low

596548

PWP2
Periodic tryptophan protein 2 homolog

1

0

High-throughput

0.232

Low

596554

Q2F837
Eukaryotic translation elongation factor 1 alpha 1

1

0

High-throughput

0.232

Low

596556

Q3B7A7
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.232

Low

596557

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.232

Low

596559

Q53EP4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.232

Low

596560

Q53G83
Small ribosomal subunit protein uS3

1

0

High-throughput

0.232

Low

596561

Q53GB0
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024