Protein: MED28
Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)

Gene: MED28
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q9H204

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016020 - membrane
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1393378

MED30
Mediator of RNA polymerase II transcription subunit 30

8

1

Small-scale

0.969

High

1431401

MED29
Mediator of RNA polymerase II transcription subunit 29

6

1

Small-scale

0.949

High

1431402

MED11
Mediator of RNA polymerase II transcription subunit 11

6

1

Small-scale

0.943

High

239616

MED14
Mediator of RNA polymerase II transcription subunit 14

5

1

High-throughput

0.922

High

1149710

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.897

High

881605

CDK8
Cyclin-dependent kinase 8

10

2

High-throughput

0.756

High

1431399

MED17
Mediator of RNA polymerase II transcription subunit 17

8

1

Small-scale

0.750

High

1416401

CDK19
Cyclin-dependent kinase 19

8

2

High-throughput

0.749

High

1151293

MED1
Mediator of RNA polymerase II transcription subunit 1

7

1

Small-scale

0.747

High

1431397

MED20
Mediator of RNA polymerase II transcription subunit 20

7

1

Small-scale

0.747

High

1431403

MED13
Mediator of RNA polymerase II transcription subunit 13

7

1

Small-scale

0.746

High

666909

CCNC
Cyclin-C

8

1

High-throughput

0.746

High

287817

MED6
Mediator of RNA polymerase II transcription subunit 6

6

1

Small-scale

0.732

High

1241412

MED27
Mediator of RNA polymerase II transcription subunit 27

6

1

Small-scale

0.732

High

1372193

MED12
Mediator of RNA polymerase II transcription subunit 12

6

1

Small-scale

0.732

High

1391335

MED8
Mediator of RNA polymerase II transcription subunit 8

6

1

Small-scale

0.730

High

49013

MED19
Mediator of RNA polymerase II transcription subunit 19

9

0

Small-scale

0.722

High

1108399

MED21
Mediator of RNA polymerase II transcription subunit 21

8

0

Small-scale

0.719

High

1259069

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

1

High-throughput

0.718

High

1431398

MED4
Mediator of RNA polymerase II transcription subunit 4

7

0

High-throughput

0.714

High

219517

MED7
Mediator of RNA polymerase II transcription subunit 7

6

0

High-throughput

0.705

High

336029

MED26
Mediator of RNA polymerase II transcription subunit 26

6

0

High-throughput

0.705

High

1414140

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

High-throughput

0.705

High

1413628

MED10
Mediator of RNA polymerase II transcription subunit 10

5

0

High-throughput

0.688

High

1431400

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

High-throughput

0.688

High

1431409

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

High-throughput

0.688

High

282417

MED24
Mediator of RNA polymerase II transcription subunit 24

5

0

High-throughput

0.684

High

667447

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

0

High-throughput

0.684

High

1401566

MED15
Mediator of RNA polymerase II transcription subunit 15

5

0

High-throughput

0.684

High

1431408

MED16
Mediator of RNA polymerase II transcription subunit 16

5

0

High-throughput

0.684

High

1295675

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

1

High-throughput

0.667

High

1259279

MED25
Mediator of RNA polymerase II transcription subunit 25

4

0

High-throughput

0.664

High

1431406

MED23
Mediator of RNA polymerase II transcription subunit 23

4

0

High-throughput

0.664

High

723086

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

0

High-throughput

0.657

High

987933

GRB2
Growth factor receptor-bound protein 2

2

7

Small-scale

0.646

High

1431404

PUF60
Poly(U)-binding-splicing factor PUF60

2

1

High-throughput

0.640

High

440724

FYN
Tyrosine-protein kinase Fyn

2

8

Small-scale

0.638

High

621964

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

0

High-throughput

0.638

High

192854

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

0

High-throughput

0.628

High

621742

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

High-throughput

0.628

High

912229

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.628

High

557467

SRC
Proto-oncogene tyrosine-protein kinase Src

2

8

Small-scale

0.612

High

1313046

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.585

High

1380156

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.585

High

1359771

TCP11
T-complex protein 11 homolog

2

0

High-throughput

0.580

High

440205

LCK
Tyrosine-protein kinase Lck

2

8

Small-scale

0.571

High

767330

MERL
Merlin

1

0

Small-scale

0.569

High

976148

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.559

High

983703

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.559

High

1431395

MED28
Mediator of RNA polymerase II transcription subunit 28

2

0

High-throughput

0.559

High

1396927

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.549

High

848940

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.518

High

136428

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

11

Small-scale

0.515

High

473472

HCK
Tyrosine-protein kinase HCK

1

8

Small-scale

0.515

High

699851

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.515

High

1054144

BTK
Tyrosine-protein kinase BTK

1

8

Small-scale

0.515

High

1215978

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

1

Small-scale

0.515

High

1428964

WWTR1
WW domain-containing transcription regulator protein 1

1

3

Small-scale

0.515

High

959400

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.513

High

1025142

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

1243773

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

184318

NPHP1
Nephrocystin-1

1

0

Small-scale

0.493

High

220804

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

Small-scale

0.493

High

1085520

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

Small-scale

0.493

High

1400014

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.493

High

843974

HD
Huntingtin

1

0

High-throughput

0.493

High

1365180

NDRG1
Protein NDRG1

1

0

High-throughput

0.493

High

463220

YES
Tyrosine-protein kinase Yes

1

8

Small-scale

0.488

High

283544

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.479

High

862445

YAP1
Transcriptional coactivator YAP1

1

3

Small-scale

0.479

High

840897

TEC
Tyrosine-protein kinase Tec

1

8

Small-scale

0.470

High

840985

ABL2
Tyrosine-protein kinase ABL2

1

8

Small-scale

0.470

High

1368298

STAM1
Signal transducing adapter molecule 1

1

1

Small-scale

0.470

High

1369904

OSTF1
Osteoclast-stimulating factor 1

1

1

Small-scale

0.470

High

686649

ELAV4
ELAV-like protein 4

1

1

High-throughput

0.470

High

260442

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

262568

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

320410

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.458

High

326371

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

787784

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

897971

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

912122

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

923536

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

1151387

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1212032

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1217611

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1257819

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1431405

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

248242

NDK8
Putative nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

505978

MYZAP
Myocardial zonula adherens protein

1

0

High-throughput

0.426

High

1431396

CENPH
Centromere protein H

1

0

High-throughput

0.426

High

76437

B4DUB1
cyclin-dependent kinase

1

2

High-throughput

0.407

High

95757

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

887213

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1332435

CBY2
Protein chibby homolog 2

3

0

High-throughput

0.352

High

352639

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

907191

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

1207688

MIIP
Migration and invasion-inhibitory protein

2

0

High-throughput

0.316

High

1232016

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

0

High-throughput

0.305

High

1199036

KLH12
Kelch-like protein 12

1

0

High-throughput

0.282

High

1330080

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.282

High

607716

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.279

Low

1179853

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1431407

STX8
Syntaxin-8

1

0

High-throughput

0.279

Low

302208

NEBL
Nebulette

1

0

Small-scale

0.269

Low

1006103

DLG4
Disks large homolog 4

1

0

Small-scale

0.269

Low

1431410

SNX9
Sorting nexin-9

1

0

Small-scale

0.269

Low

599309

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

0

Small-scale

0.249

Low

1216091

SPD2A
SH3 and PX domain-containing protein 2A

1

0

Small-scale

0.249

Low

506027

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025