Protein: PK1IP
p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)

Gene: PK1IP, PAK1IP1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9NWT1

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0004860 - protein kinase inhibitor activity
GO:0005730 - nucleolus
GO:0008283 - cell population proliferation
GO:0009968 - negative regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

984564

RL30
Large ribosomal subunit protein eL30

2

3

High-throughput

0.726

High

1313166

ZC3H3
Zinc finger CCCH domain-containing protein 3

2

1

High-throughput

0.705

High

1436610

PKHF2
Pleckstrin homology domain-containing family F member 2

2

8

High-throughput

0.700

High

975985

RL7A
Large ribosomal subunit protein eL8

1

10

High-throughput

0.691

High

1446767

SSF1
Suppressor of SWI4 1 homolog

2

2

High-throughput

0.628

High

502563

H2A1
Histone H2A type 1

1

7

High-throughput

0.618

High

182381

WDR46
WD repeat-containing protein 46

1

18

High-throughput

0.618

High

1451389

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

9

High-throughput

0.618

High

447505

NPM
Nucleophosmin

2

8

High-throughput

0.611

High

898857

RL14
Large ribosomal subunit protein eL14

2

4

High-throughput

0.611

High

979300

RS6
Small ribosomal subunit protein eS6

2

4

High-throughput

0.611

High

1361779

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

373297

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

894204

MEOX2
Homeobox protein MOX-2

2

6

High-throughput

0.584

High

1395836

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.578

High

72820

B0UZZ8
WD repeat-containing protein 46

1

17

High-throughput

0.575

High

521976

H14
Histone H1.4

2

11

High-throughput

0.574

High

961863

RL37A
Large ribosomal subunit protein eL43

2

3

High-throughput

0.574

High

977097

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

4

High-throughput

0.574

High

694024

RL10
Large ribosomal subunit protein uL16

2

5

High-throughput

0.558

High

854945

RECQ1
ATP-dependent DNA helicase Q1

1

20

High-throughput

0.553

High

971175

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

12

High-throughput

0.553

High

1204844

DDX6L
Probable ATP-dependent RNA helicase DDX60-like

1

17

High-throughput

0.553

High

1255795

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

1447338

ANLN
Anillin

1

5

High-throughput

0.553

High

1232607

Q6FHY5
MEOX2 protein

2

6

High-throughput

0.544

High

288796

NPM3
Nucleoplasmin-3

1

8

High-throughput

0.536

High

290763

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.536

High

662662

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

6

High-throughput

0.536

High

686477

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.536

High

785487

RL4
Large ribosomal subunit protein uL4

1

5

High-throughput

0.536

High

809882

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.536

High

824393

RL13A
Large ribosomal subunit protein uL13

1

8

High-throughput

0.536

High

833210

MNDA
Myeloid cell nuclear differentiation antigen

1

5

High-throughput

0.536

High

841480

RBM34
RNA-binding protein 34

1

18

High-throughput

0.536

High

842570

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

854345

KI67
Proliferation marker protein Ki-67

1

9

High-throughput

0.536

High

860983

RS10
Small ribosomal subunit protein eS10

1

6

High-throughput

0.536

High

969484

RS8
Small ribosomal subunit protein eS8

1

4

High-throughput

0.536

High

978760

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

985918

RL11
Large ribosomal subunit protein uL5

1

5

High-throughput

0.536

High

1016260

RL19
Large ribosomal subunit protein eL19

1

4

High-throughput

0.536

High

1057930

RL18
Large ribosomal subunit protein eL18

1

4

High-throughput

0.536

High

1099279

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.536

High

1409859

RBM4B
RNA-binding protein 4B

1

16

High-throughput

0.536

High

1410752

MBB1A
Myb-binding protein 1A

1

4

High-throughput

0.536

High

1416134

RBM4
RNA-binding protein 4

1

15

High-throughput

0.536

High

1437364

LN28A
Protein lin-28 homolog A

1

9

High-throughput

0.536

High

1451016

RBM28
RNA-binding protein 28

1

14

High-throughput

0.536

High

1451387

LYAR
Cell growth-regulating nucleolar protein

1

4

High-throughput

0.536

High

1451395

ZN346
Zinc finger protein 346

1

4

High-throughput

0.536

High

1451397

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1451398

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.536

High

1096508

PAK1
Serine/threonine-protein kinase PAK 1

1

13

Small-scale

0.523

High

397064

ESR1
Estrogen receptor

2

19

High-throughput

0.521

High

1112205

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.513

High

1411897

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.513

High

191837

MAGB2
Melanoma-associated antigen B2

1

9

High-throughput

0.489

High

287165

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

18

High-throughput

0.489

High

429021

RLA0
Large ribosomal subunit protein uL10

1

8

High-throughput

0.489

High

476851

RSSA
Small ribosomal subunit protein uS2

1

3

High-throughput

0.489

High

586921

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.489

High

616018

RL17
Large ribosomal subunit protein uL22

1

5

High-throughput

0.489

High

788795

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.489

High

860030

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.489

High

911408

IMA5
Importin subunit alpha-5

1

8

High-throughput

0.489

High

985033

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.489

High

985362

RL10A
Large ribosomal subunit protein uL1

1

9

High-throughput

0.489

High

986248

RL8
Large ribosomal subunit protein uL2

1

3

High-throughput

0.489

High

1037410

H11
Histone H1.1

1

11

High-throughput

0.489

High

1037671

RL18A
Large ribosomal subunit protein eL20

1

2

High-throughput

0.489

High

1061179

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.489

High

1062134

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.489

High

1099573

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.489

High

1178103

RN151
RING finger protein 151

1

14

High-throughput

0.489

High

1275717

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

7

High-throughput

0.489

High

1451390

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.489

High

1451393

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.489

High

406717

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

810421

RL3
Large ribosomal subunit protein uL3

1

8

High-throughput

0.479

High

900192

FXR1
RNA-binding protein FXR1

1

7

High-throughput

0.479

High

1028416

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

1161710

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

1393756

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1418621

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

14

High-throughput

0.479

High

1451388

RCC2
Protein RCC2

1

11

Small-scale

0.479

High

1451392

NOL12
Nucleolar protein 12

1

1

High-throughput

0.479

High

1130488

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

9

High-throughput

0.445

High

725553

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

4

High-throughput

0.439

High

1049026

REL
Proto-oncogene c-Rel

1

15

High-throughput

0.439

High

129481

MEN1
Menin

1

3

High-throughput

0.437

High

227687

SPOP
Speckle-type POZ protein

1

6

High-throughput

0.437

High

248109

NUPR1
Nuclear protein 1

1

3

High-throughput

0.437

High

248361

HBP1
HMG box-containing protein 1

1

12

High-throughput

0.437

High

260531

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.437

High

320092

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.437

High

401581

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.437

High

473129

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.437

High

589851

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696670

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

769337

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

879529

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.437

High

905200

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.437

High

937938

FOXA1
Hepatocyte nuclear factor 3-alpha

1

7

High-throughput

0.437

High

942922

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.437

High

1024878

VIGLN
Vigilin

1

17

High-throughput

0.437

High

1100454

TIF1B
Transcription intermediary factor 1-beta

1

18

High-throughput

0.437

High

1107270

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.437

High

1114444

CUL3
Cullin-3

1

20

Small-scale

0.437

High

1138103

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.437

High

1290769

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.437

High

1329903

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.437

High

1352787

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.437

High

1367413

ESR2
Estrogen receptor beta

1

18

High-throughput

0.437

High

1402324

RANB9
Ran-binding protein 9

1

16

High-throughput

0.437

High

1451391

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.437

High

1451396

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.437

High

1451394

AGO1
Protein argonaute-1

1

1

High-throughput

0.407

High

1393170

PRR11
Proline-rich protein 11

2

0

High-throughput

0.318

High

137487

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.279

Low

1127521

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1390636

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

1395719

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1412398

ZNF2
Zinc finger protein 2

1

0

High-throughput

0.279

Low

1447670

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

0

High-throughput

0.279

Low

1412514

TINF2
TERF1-interacting nuclear factor 2

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025