Protein: IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)

Gene: IDHC, IDH1
Organism: Homo sapiens
Interactions: 75
UniProt ID: O75874

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004450 - isocitrate dehydrogenase (NADP+) activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296015

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

5

2

Small-scale

0.913

High

240312

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

296016

AGR2
Anterior gradient protein 2 homolog

2

1

Small-scale

0.584

High

296043

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

296079

SHOC2
Leucine-rich repeat protein SHOC-2

2

1

High-throughput

0.571

High

296020

CALM1
Calmodulin-1

1

0

Small-scale

0.564

High

296019

CDK1
Cyclin-dependent kinase 1

1

3

Small-scale

0.561

High

296042

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.561

High

296063

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

296053

FIGL1
Fidgetin-like protein 1

1

7

High-throughput

0.541

High

296036

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.518

High

296059

LAX1
Lymphocyte transmembrane adapter 1

1

0

High-throughput

0.518

High

296061

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

0

High-throughput

0.518

High

296068

UBL7
Ubiquitin-like protein 7

1

0

High-throughput

0.518

High

296032

CALR
Calreticulin

1

3

High-throughput

0.515

High

296035

TGFR2
TGF-beta receptor type-2

1

1

High-throughput

0.515

High

296045

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.515

High

296018

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

296082

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

296085

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

296027

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

296028

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

296034

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

296066

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.493

High

296025

BRAF
Serine/threonine-protein kinase B-raf

1

0

High-throughput

0.484

High

296017

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

296023

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

296024

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

2

High-throughput

0.479

High

296029

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

296030

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

296038

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

296047

CUL1
Cullin-1

1

1

High-throughput

0.479

High

296054

TRI65
E3 ubiquitin-protein ligase TRIM65

1

3

Small-scale

0.479

High

296055

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

296057

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

296064

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

296067

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

296072

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

296076

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

296077

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

296081

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

134990

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

143511

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.458

High

296022

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

296037

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

296039

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

296046

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

296051

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

296058

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

296069

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

296071

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

296021

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

296048

CUL3
Cullin-3

1

1

High-throughput

0.445

High

296052

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.445

High

296073

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

296080

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

296060

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.438

High

296026

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

296031

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

296033

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

296044

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

296050

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

296041

PEX5
Peroxisomal targeting signal 1 receptor

1

1

Small-scale

0.408

High

296049

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.282

High

296056

F131A
Protein FAM131A

1

0

High-throughput

0.282

High

296062

EFC4A
EF-hand calcium-binding domain-containing protein 4A

1

0

High-throughput

0.282

High

296070

PRD14
PR domain zinc finger protein 14

1

0

High-throughput

0.282

High

296074

TMOD4
Tropomodulin-4

1

0

High-throughput

0.282

High

296075

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.282

High

296078

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.282

High

296065

ATLA2
Atlastin-2

1

0

High-throughput

0.279

Low

296040

SERPH
Serpin H1

1

0

High-throughput

0.268

Low

296083

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low

296084

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025