Protein: PRDX5
Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)

Gene: PRDX5
Organism: Homo sapiens
Interactions: 91
UniProt ID: P30044

Gene Ontology (top 5):
GO:0001016 - RNA polymerase III transcription regulatory region sequence-specific DNA binding
GO:0004601 - peroxidase activity
GO:0005102 - signaling receptor binding
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

716401

PRDX5
Peroxiredoxin-5, mitochondrial

1

3

Small-scale

0.734

High

716415

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

1

High-throughput

0.606

High

529162

TAU
Microtubule-associated protein tau

2

2

High-throughput

0.601

High

716410

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.580

High

716441

NUFP2
FMR1-interacting protein NUFIP2

2

0

High-throughput

0.580

High

410648

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

2

High-throughput

0.576

High

641494

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

2

High-throughput

0.576

High

716433

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

2

High-throughput

0.576

High

395557

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

716466

SHOC2
Leucine-rich repeat protein SHOC-2

2

1

High-throughput

0.571

High

361131

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.565

High

400344

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

716412

PPT1
Palmitoyl-protein thioesterase 1

2

0

Small-scale

0.559

High

716431

ARHG6
Rho guanine nucleotide exchange factor 6

2

0

High-throughput

0.547

High

716452

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

180718

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.536

High

716458

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.518

High

556900

MYH7
Myosin-7

1

0

High-throughput

0.513

High

583469

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.513

High

716407

MAGA1
Melanoma-associated antigen 1

1

0

High-throughput

0.513

High

716417

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

716419

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.513

High

716424

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

716427

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

716442

URP2
Fermitin family homolog 3

1

0

High-throughput

0.513

High

716443

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

716461

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

716463

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.513

High

716469

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

716425

SCRIB
Protein scribble homolog

1

1

High-throughput

0.501

High

716406

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

716446

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

1

High-throughput

0.489

High

421564

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

716409

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.480

High

403849

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

716413

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

716422

DUSP2
Dual specificity protein phosphatase 2

1

3

High-throughput

0.479

High

716423

DUS4
Dual specificity protein phosphatase 4

1

3

High-throughput

0.479

High

716426

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

716447

DUS19
Dual specificity protein phosphatase 19

1

3

High-throughput

0.479

High

716448

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

716451

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

716457

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

716465

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.479

High

214391

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.458

High

259498

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

293257

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

321441

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.458

High

353012

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

651176

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

664645

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

716402

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

716403

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

716404

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

716405

BASI
Basigin

1

0

High-throughput

0.458

High

716408

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

716416

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

716418

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

716421

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

716428

ZN846
Zinc finger protein 846

1

0

High-throughput

0.458

High

716430

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

716432

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

716434

RHG31
Rho GTPase-activating protein 31

1

0

High-throughput

0.458

High

716436

ERIC3
Glutamate-rich protein 3

1

0

High-throughput

0.458

High

716439

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

716440

DET1
DET1 homolog

1

0

High-throughput

0.458

High

716444

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.458

High

716445

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

716449

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

716450

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

716453

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

716454

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

716459

SHRPN
Sharpin

1

0

Small-scale

0.458

High

716460

ANLN
Anillin

1

0

High-throughput

0.458

High

716462

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

716464

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

716414

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

716420

TAGL
Transgelin

1

1

High-throughput

0.445

High

653145

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

716437

LIN54
Protein lin-54 homolog

1

0

Small-scale

0.426

High

716470

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

716411

PEX5
Peroxisomal targeting signal 1 receptor

1

0

Small-scale

0.391

High

716468

PCDBF
Protocadherin beta-15

1

0

High-throughput

0.279

Low

716435

DCA10
DDB1- and CUL4-associated factor 10

1

0

High-throughput

0.269

Low

716455

YJU2
Splicing factor YJU2

1

0

High-throughput

0.269

Low

105412

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

716467

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

716429

NTCP
Hepatic sodium/bile acid cotransporter

1

0

High-throughput

0.232

Low

716438

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

716456

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025