Protein: PNPH
Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)

Gene: PNPH, PNP
Organism: Homo sapiens
Interactions: 82
UniProt ID: P00491

Gene Ontology (top 5):
GO:0000255 - allantoin metabolic process
GO:0001882 - nucleoside binding
GO:0002060 - purine nucleobase binding
GO:0004731 - purine-nucleoside phosphorylase activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

361761

PNPH
Purine nucleoside phosphorylase

7

5

Small-scale

0.954

High

269722

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

2

1

High-throughput

0.576

High

240425

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

361828

SHOC2
Leucine-rich repeat protein SHOC-2

2

0

High-throughput

0.547

High

361783

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

361797

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

361804

CDKL3
Cyclin-dependent kinase-like 3

1

1

High-throughput

0.536

High

361764

P53
Cellular tumor antigen p53

1

0

High-throughput

0.518

High

361770

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

361765

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

361817

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.515

High

213754

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

361831

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

361787

APLP1
Amyloid beta precursor like protein 1

1

1

High-throughput

0.494

High

361819

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

0

High-throughput

0.493

High

156580

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

0

High-throughput

0.493

High

361766

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

361772

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.493

High

361774

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

361792

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.493

High

361796

TGIF1
Homeobox protein TGIF1

1

0

High-throughput

0.493

High

361809

SORL
Sortilin-related receptor

1

0

High-throughput

0.493

High

361810

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

361830

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.493

High

361820

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.489

High

352814

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.479

High

361771

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

361775

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

361784

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

361786

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

361788

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

361789

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

361803

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

361808

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

361824

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.479

High

128704

MEN1
Menin

1

0

High-throughput

0.458

High

178135

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

361762

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

361763

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

361767

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

361769

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

361777

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.458

High

361778

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

361779

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

361782

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

361790

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

361791

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

361794

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

361795

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

361805

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

361806

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

361807

CC110
Coiled-coil domain-containing protein 110

1

0

High-throughput

0.458

High

361811

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

361812

OPTN
Optineurin

1

0

High-throughput

0.458

High

361813

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

361821

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

361826

MYO15
Unconventional myosin-XV

1

0

High-throughput

0.458

High

361800

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.457

High

361822

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

361773

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

361780

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

361781

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

361802

LMTK1
Serine/threonine-protein kinase LMTK1

1

2

High-throughput

0.437

High

361814

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.437

High

295441

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

High-throughput

0.426

High

361768

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

361776

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

361793

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

Small-scale

0.426

High

361801

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

361815

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

361829

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

330015

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

361785

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

361798

RBM48
RNA-binding protein 48

1

0

High-throughput

0.282

High

361818

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.282

High

361827

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.282

High

361799

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

239646

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

361816

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

361823

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.249

Low

361825

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025