Protein: PUR9
Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]

Gene: PUR9, ATIC
Organism: Homo sapiens
Interactions: 100
UniProt ID: P31939

Gene Ontology (top 5):
GO:0003360 - brainstem development
GO:0003937 - IMP cyclohydrolase activity
GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362846

EGFR
Epidermal growth factor receptor

2

3

Small-scale

0.608

High

240869

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

667575

CDK2
Cyclin-dependent kinase 2

2

0

High-throughput

0.559

High

728939

KPCE
Protein kinase C epsilon type

2

0

High-throughput

0.547

High

728940

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

728980

SHOC2
Leucine-rich repeat protein SHOC-2

2

0

High-throughput

0.547

High

439658

INSR
Insulin receptor

1

3

Small-scale

0.536

High

728924

ARL3
ADP-ribosylation factor-like protein 3

1

1

High-throughput

0.536

High

728950

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

728956

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.536

High

728984

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

728933

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

425339

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.515

High

213834

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

413274

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

728935

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

728947

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

728972

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

172023

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

0

High-throughput

0.493

High

220742

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.493

High

648095

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.493

High

690186

STOM
Stomatin

1

0

High-throughput

0.493

High

728937

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.493

High

728943

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.493

High

728965

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.493

High

728982

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.493

High

728929

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.486

High

185463

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

157001

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

169972

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

411444

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

560310

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

606306

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

658639

JAK1
Tyrosine-protein kinase JAK1

1

1

High-throughput

0.479

High

728928

NSF
Vesicle-fusing ATPase

1

1

High-throughput

0.479

High

728931

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

728932

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

728938

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

728962

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.479

High

728974

MYO10
Unconventional myosin-X

1

2

Small-scale

0.479

High

728979

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

728967

RADIL
Ras-associating and dilute domain-containing protein

1

2

High-throughput

0.470

High

222755

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

302395

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

400368

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

459229

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

536595

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

555898

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

728922

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

728926

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

728927

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

728934

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

728936

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

728942

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

728944

CUL7
Cullin-7

1

0

High-throughput

0.458

High

728951

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.458

High

728954

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

728957

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

728959

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

728961

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

728963

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

728964

KAT6A
Histone acetyltransferase KAT6A

1

0

Small-scale

0.458

High

728968

NECD
Necdin

1

0

High-throughput

0.458

High

728969

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

728971

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

728977

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

728978

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

728981

AT11B
Phospholipid-transporting ATPase IF

1

0

High-throughput

0.458

High

728983

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

142861

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.437

High

473817

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

728946

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.437

High

529189

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

728949

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

728955

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

728966

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

728973

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

728930

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

105430

APRIO
Alternative prion protein

2

0

Small-scale

0.306

High

728970

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

477927

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.269

Low

728925

SPB5
Serpin B5

1

0

Small-scale

0.251

Low

259512

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

353026

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

370161

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

371283

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

588010

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

657350

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

685418

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.249

Low

694723

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

728923

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

728945

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

728948

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

728952

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

728953

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

728958

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

728960

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

728975

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

728976

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

728941

P
P protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025