Protein: FZD6
Frizzled-6 (Fz-6) (hFz6)

Gene: FZD6
Organism: Homo sapiens
Interactions: 59
UniProt ID: O60353

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001843 - neural tube closure
GO:0001942 - hair follicle development
GO:0004930 - G protein-coupled receptor activity
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

247528

SFRP1
Secreted frizzled-related protein 1

1

10

Small-scale

0.665

High

247535

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

247489

VNN2
Pantetheine hydrolase VNN2

2

3

High-throughput

0.628

High

247523

TMPSC
Transmembrane protease serine 12

2

3

High-throughput

0.628

High

247530

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

6

High-throughput

0.628

High

247512

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

3

4

High-throughput

0.609

High

247526

SYNE4
Nesprin-4

3

2

High-throughput

0.609

High

247505

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

2

3

High-throughput

0.601

High

247525

AGRG5
Adhesion G-protein coupled receptor G5

2

6

High-throughput

0.601

High

247492

ACHA
Acetylcholine receptor subunit alpha

1

3

High-throughput

0.536

High

247494

CD1A
T-cell surface glycoprotein CD1a

1

1

High-throughput

0.536

High

247499

GPIX
Platelet glycoprotein IX

1

2

High-throughput

0.536

High

247502

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

4

High-throughput

0.536

High

247503

CALX
Calnexin

1

3

High-throughput

0.536

High

247504

SCN4A
Sodium channel protein type 4 subunit alpha

1

4

High-throughput

0.536

High

247515

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

3

High-throughput

0.536

High

247519

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

1

High-throughput

0.536

High

247520

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

247522

LRC55
Leucine-rich repeat-containing protein 55

1

1

High-throughput

0.536

High

247543

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.536

High

247490

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

247495

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

247497

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

247498

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.513

High

247501

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

0

High-throughput

0.513

High

247516

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

247532

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

247536

UD17
UDP-glucuronosyltransferase 1A7

1

0

High-throughput

0.513

High

247538

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.513

High

247540

DAPLE
Protein Daple

1

2

Small-scale

0.501

High

217576

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

247491

RASH
GTPase HRas

1

2

High-throughput

0.479

High

247496

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

247500

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

247508

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.479

High

247509

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

247510

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.479

High

247511

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

247542

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

6

Small-scale

0.479

High

247507

NPTX2
Neuronal pentraxin-2

1

2

Small-scale

0.470

High

247488

ABCA8
ABC-type organic anion transporter ABCA8

1

0

High-throughput

0.458

High

247493

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

247513

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

247521

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

247539

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

247541

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

170572

CLGN
Calmegin

1

3

High-throughput

0.445

High

247506

OR1D4
Olfactory receptor 1D4

1

5

High-throughput

0.445

High

247514

TRDN
Triadin

1

3

High-throughput

0.445

High

247524

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

222234

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

247527

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

247533

TM169
Transmembrane protein 169

1

3

High-throughput

0.407

High

247534

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.407

High

247537

POPD2
Popeye domain-containing protein 2

1

1

High-throughput

0.407

High

247517

TMM95
Sperm-egg fusion protein TMEM95

2

0

High-throughput

0.313

High

247518

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

247531

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

247529

NEUFC
Neuferricin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025