Protein: WDFY1
WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)

Gene: WDFY1
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q8IWB7

Gene Ontology (top 5):
GO:0005545 - 1-phosphatidylinositol binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1252885

BAKOR
Beclin 1-associated autophagy-related key regulator

2

1

High-throughput

0.789

High

186926

GPR37
Prosaposin receptor GPR37

2

5

High-throughput

0.726

High

326439

S1PR2
Sphingosine 1-phosphate receptor 2

2

3

High-throughput

0.726

High

989353

VAMP2
Vesicle-associated membrane protein 2

3

5

High-throughput

0.675

High

1154670

VAMP3
Vesicle-associated membrane protein 3

3

6

High-throughput

0.675

High

276323

HMMR
Hyaluronan mediated motility receptor

2

15

High-throughput

0.628

High

325496

CCNB2
G2/mitotic-specific cyclin-B2

2

2

High-throughput

0.628

High

1309832

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

6

High-throughput

0.628

High

1309841

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

2

5

High-throughput

0.628

High

1309842

DAPLE
Protein Daple

2

10

High-throughput

0.628

High

948070

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

1

High-throughput

0.618

High

1157801

DDB1
DNA damage-binding protein 1

1

14

Small-scale

0.618

High

1254531

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1309563

F219A
Protein FAM219A

3

2

High-throughput

0.609

High

242208

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.584

High

1194642

KCD21
BTB/POZ domain-containing protein KCTD21

2

7

High-throughput

0.574

High

178962

SCAM2
Secretory carrier-associated membrane protein 2

1

3

High-throughput

0.536

High

189682

STX7
Syntaxin-7

1

2

High-throughput

0.536

High

613095

EGR1
Early growth response protein 1

1

3

High-throughput

0.536

High

901374

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.536

High

976392

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.536

High

1136981

SEPT2
Septin-2

1

6

High-throughput

0.536

High

1309835

VAMP8
Vesicle-associated membrane protein 8

1

5

High-throughput

0.536

High

785844

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.513

High

1309838

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1309839

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

0

High-throughput

0.513

High

1309844

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.513

High

178806

SCAM1
Secretory carrier-associated membrane protein 1

1

3

High-throughput

0.489

High

222382

TSN6
Tetraspanin-6

1

2

High-throughput

0.489

High

1309840

SEP11
Septin-11

1

6

High-throughput

0.489

High

191225

TLR3
Toll-like receptor 3

1

4

Small-scale

0.479

High

562194

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

Small-scale

0.479

High

589097

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

695881

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

1107891

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

1309843

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1309845

LHX6
LIM/homeobox protein Lhx6

1

4

High-throughput

0.479

High

1276200

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1309829

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1053028

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.445

High

1131761

LBR
Delta(14)-sterol reductase LBR

1

2

High-throughput

0.445

High

1309830

GOLM1
Golgi membrane protein 1

1

1

Small-scale

0.445

High

768593

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1309831

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

926801

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.407

High

1277275

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

1

High-throughput

0.407

High

329557

STBD1
Starch-binding domain-containing protein 1

3

0

High-throughput

0.347

High

1309828

PORIM
Porimin

3

0

High-throughput

0.342

High

1309833

MERB1
bMERB domain-containing protein 1

2

0

High-throughput

0.328

High

1309837

CIAO3
Cytosolic iron-sulfur assembly component 3

2

0

High-throughput

0.328

High

1309834

S35A5
UDP-sugar transporter protein SLC35A5

1

0

High-throughput

0.232

Low

1309836

S19A3
Thiamine transporter 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025