Protein: RNF25
E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7)

Gene: RNF25
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q96BH1

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982275

UB2D2
Ubiquitin-conjugating enzyme E2 D2

9

14

Small-scale

0.977

High

957156

UB2D3
Ubiquitin-conjugating enzyme E2 D3

8

14

Small-scale

0.972

High

1381178

UB2E3
Ubiquitin-conjugating enzyme E2 E3

7

14

Small-scale

0.970

High

906735

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

14

Small-scale

0.952

High

1384580

UB2D4
Ubiquitin-conjugating enzyme E2 D4

5

14

High-throughput

0.935

High

909367

UB2E1
Ubiquitin-conjugating enzyme E2 E1

4

14

High-throughput

0.912

High

1384575

UB2E2
Ubiquitin-conjugating enzyme E2 E2

4

14

High-throughput

0.903

High

168556

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

16

High-throughput

0.698

High

1384574

RNF25
E3 ubiquitin-protein ligase RNF25

1

2

Small-scale

0.647

High

242527

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.630

High

537672

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

724615

S10A7
Protein S100-A7

2

1

High-throughput

0.628

High

1218741

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

15

High-throughput

0.625

High

1194646

KCD21
BTB/POZ domain-containing protein KCTD21

2

1

High-throughput

0.606

High

457899

INVO
Involucrin

2

0

High-throughput

0.602

High

874838

SPB4
Serpin B4

2

0

High-throughput

0.602

High

1384578

RFOX1
RNA binding protein fox-1 homolog 1

2

0

High-throughput

0.602

High

508405

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.586

High

1045618

TF65
Transcription factor p65

1

0

Small-scale

0.549

High

225323

HTSF1
17S U2 SnRNP complex component HTATSF1

1

1

High-throughput

0.536

High

572114

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.518

High

1232508

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

479459

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

1097860

STX5
Syntaxin-5

1

0

High-throughput

0.513

High

1323563

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

1358335

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.513

High

608325

EGLN
Endoglin

1

1

High-throughput

0.489

High

894080

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

831204

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

1254972

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1365723

GCN1
Stalled ribosome sensor GCN1

1

2

Small-scale

0.479

High

279449

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

612728

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.458

High

973257

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

1013168

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

1384576

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

530191

TAU
Microtubule-associated protein tau

1

0

Small-scale

0.426

High

1384577

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

3

0

High-throughput

0.347

High

1009694

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.279

Low

1246100

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.279

Low

1379851

UCN3
Urocortin-3

1

0

High-throughput

0.279

Low

1384579

STX18
Syntaxin-18

1

0

High-throughput

0.279

Low

1379902

NKD2
Protein naked cuticle homolog 2

1

0

Small-scale

0.278

Low

379127

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low

516709

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

1384581

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025