Protein: PYGL
Glycogen phosphorylase, liver form (EC 2.4.1.1)

Gene: PYGL
Organism: Homo sapiens
Interactions: 104
UniProt ID: P06737

Gene Ontology (top 5):
GO:0002060 - purine nucleobase binding
GO:0005524 - ATP binding
GO:0005536 - D-glucose binding
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

446118

PYGB
Glycogen phosphorylase, brain form

5

8

High-throughput

0.940

High

446119

PYGM
Glycogen phosphorylase, muscle form

2

8

High-throughput

0.783

High

446124

NTF3
Neurotrophin-3

2

1

High-throughput

0.611

High

446147

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

2

High-throughput

0.611

High

446168

ZFP41
Zinc finger protein 41 homolog

3

1

High-throughput

0.609

High

240498

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

446116

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

Small-scale

0.584

High

446164

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

3

High-throughput

0.584

High

446112

PYGL
Glycogen phosphorylase, liver form

1

8

Small-scale

0.575

High

413019

P53
Cellular tumor antigen p53

2

0

High-throughput

0.547

High

329499

STBD1
Starch-binding domain-containing protein 1

1

2

High-throughput

0.536

High

446121

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

446143

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.536

High

446152

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

446175

GASP2
G-protein coupled receptor-associated sorting protein 2

1

2

High-throughput

0.536

High

446182

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

446190

HSPB8
Heat shock protein beta-8

1

2

High-throughput

0.536

High

259310

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.533

High

446181

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.518

High

167790

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

0

High-throughput

0.513

High

322895

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.513

High

446133

PRS6B
26S proteasome regulatory subunit 6B

1

0

High-throughput

0.513

High

446162

TPC11
Trafficking protein particle complex subunit 11

1

0

High-throughput

0.513

High

446195

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

446193

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

0

High-throughput

0.493

High

169897

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

227315

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

446115

PGFRB
Platelet-derived growth factor receptor beta

1

4

High-throughput

0.479

High

446117

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

446123

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

446126

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.479

High

446129

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

446138

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

446144

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

446146

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

446149

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

446151

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

446157

FTM
Protein fantom

1

1

High-throughput

0.479

High

446158

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

446165

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

446172

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

446177

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

446178

SCLT1
Sodium channel and clathrin linker 1

1

1

High-throughput

0.479

High

446179

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

446186

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.479

High

446187

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

446188

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

446189

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

446194

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

1

High-throughput

0.470

High

446134

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.460

High

446180

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.460

High

125149

LEG9
Galectin-9

1

0

High-throughput

0.458

High

258051

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

289913

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

293068

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

345265

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

359782

DYR
Dihydrofolate reductase

1

0

High-throughput

0.458

High

446114

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

446120

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

446128

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

446130

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

446139

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

446141

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

446142

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

446148

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

446154

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

446160

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

446170

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

446173

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

446174

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

446184

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

446192

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

126962

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

446155

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

446156

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

446159

NEK10
Serine/threonine-protein kinase Nek10

1

2

High-throughput

0.445

High

105129

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

370936

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

446122

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

446125

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

446127

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

446161

KCTD9
BTB/POZ domain-containing protein KCTD9

1

1

High-throughput

0.437

High

446166

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.437

High

446167

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

446191

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

446131

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

446135

SL9A3
Sodium/hydrogen exchanger 3

1

0

High-throughput

0.426

High

446140

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.426

High

446145

TAGL
Transgelin

1

0

High-throughput

0.426

High

446137

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

254737

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

446169

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

3

0

High-throughput

0.347

High

446150

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.279

Low

446176

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

446185

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.251

Low

424729

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.249

Low

446113

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.249

Low

446136

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

446153

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.249

Low

446163

ANKAR
Ankyrin and armadillo repeat-containing protein

1

0

High-throughput

0.249

Low

446132

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

446171

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

446183

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025