Protein: IF2P
Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2)

Gene: IF2P, EIF5B
Organism: Homo sapiens
Interactions: 202
UniProt ID: O60841

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

158610

IF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal

1

6

Small-scale

0.647

High

258185

ECT2
Protein ECT2

2

6

High-throughput

0.620

High

258130

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

9

High-throughput

0.618

High

258143

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.618

High

258160

TTC29
Tetratricopeptide repeat protein 29

2

1

High-throughput

0.611

High

258190

C42S1
CDC42 small effector protein 1

2

0

High-throughput

0.602

High

258081

BRCA1
Breast cancer type 1 susceptibility protein

2

5

High-throughput

0.586

High

240246

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

258022

OBSL1
Obscurin-like protein 1

2

4

High-throughput

0.584

High

258054

HS90A
Heat shock protein HSP 90-alpha

2

9

High-throughput

0.584

High

258120

SQSTM
Sequestosome-1

2

2

High-throughput

0.584

High

258168

FBXW7
F-box/WD repeat-containing protein 7

2

4

Small-scale

0.584

High

258040

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

258050

ENOA
Alpha-enolase

2

0

High-throughput

0.559

High

258191

PIHD1
PIH1 domain-containing protein 1

2

0

Small-scale

0.559

High

258161

ZBT38
Zinc finger and BTB domain-containing protein 38

2

1

High-throughput

0.558

High

258067

ETS1
Protein C-ets-1

1

0

High-throughput

0.554

High

258102

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.550

High

219890

XRCC3
DNA repair protein XRCC3

1

3

High-throughput

0.536

High

258064

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

258117

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

4

High-throughput

0.536

High

258139

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

4

High-throughput

0.536

High

258154

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

258156

DDX60
Probable ATP-dependent RNA helicase DDX60

1

2

High-throughput

0.536

High

258019

BRD4
Bromodomain-containing protein 4

2

5

High-throughput

0.533

High

258023

HMMR
Hyaluronan mediated motility receptor

1

3

High-throughput

0.515

High

258127

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.515

High

231661

PEX1
Peroxisomal ATPase PEX1

1

4

High-throughput

0.515

High

258073

GRN
Progranulin

1

2

High-throughput

0.515

High

258074

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

258090

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

258105

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

258133

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

258096

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.501

High

258183

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

4

High-throughput

0.494

High

258039

FINC
Fibronectin

1

5

High-throughput

0.489

High

258108

FOXK2
Forkhead box protein K2

1

1

High-throughput

0.489

High

258115

FOXD4
Forkhead box protein D4

1

1

High-throughput

0.489

High

258025

WBP4
WW domain-binding protein 4

1

2

High-throughput

0.481

High

258113

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.481

High

258164

SRS12
Serine/arginine-rich splicing factor 12

1

3

High-throughput

0.481

High

131612

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

156754

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

172316

XPO1
Exportin-1

1

5

High-throughput

0.479

High

222568

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

227270

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

247188

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

4

High-throughput

0.479

High

256713

H2B1K
Histone H2B type 1-K

1

3

High-throughput

0.479

High

258024

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

258027

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.479

High

258028

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

258029

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.479

High

258031

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

High-throughput

0.479

High

258032

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

High-throughput

0.479

High

258033

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

258036

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

258038

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.479

High

258041

GCR
Glucocorticoid receptor

1

8

High-throughput

0.479

High

258045

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

258047

RLA2
Large ribosomal subunit protein P2

1

1

High-throughput

0.479

High

258055

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.479

High

258057

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

258058

VIME
Vimentin

1

1

High-throughput

0.479

High

258059

ANXA5
Annexin A5

1

1

High-throughput

0.479

High

258060

HMGB1
High mobility group protein B1

1

8

High-throughput

0.479

High

258061

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

258063

H14
Histone H1.4

1

1

High-throughput

0.479

High

258066

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

258069

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

258071

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

258075

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

258076

1433S
14-3-3 protein sigma

1

9

Small-scale

0.479

High

258077

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

258078

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

258080

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

258082

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

258085

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

258087

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.479

High

258088

RL14
Large ribosomal subunit protein eL14

1

3

High-throughput

0.479

High

258089

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

258091

RM12
Large ribosomal subunit protein bL12m

1

4

High-throughput

0.479

High

258092

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

258093

NP1L1
Nucleosome assembly protein 1-like 1

1

4

High-throughput

0.479

High

258095

IF6
Eukaryotic translation initiation factor 6

1

2

High-throughput

0.479

High

258097

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

High-throughput

0.479

High

258099

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

258100

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.479

High

258106

CDK5
Cyclin-dependent kinase 5

1

5

High-throughput

0.479

High

258107

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

258109

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

258110

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

258111

FAK1
Focal adhesion kinase 1

1

2

Small-scale

0.479

High

258114

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

10

High-throughput

0.479

High

258116

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

258119

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

258122

CUL3
Cullin-3

1

7

High-throughput

0.479

High

258125

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.479

High

258128

CUL7
Cullin-7

1

4

High-throughput

0.479

High

258129

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

258131

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

258134

SMAD2
Mothers against decapentaplegic homolog 2

1

4

High-throughput

0.479

High

258137

DREB
Drebrin

1

2

High-throughput

0.479

High

258141

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

258146

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

258149

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.479

High

258155

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

258165

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

258166

NELL1
Protein kinase C-binding protein NELL1

1

1

Small-scale

0.479

High

258167

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

258172

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

258176

DNJC2
DnaJ homolog subfamily C member 2

1

6

High-throughput

0.479

High

258178

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

258179

TRI31
E3 ubiquitin-protein ligase TRIM31

1

8

High-throughput

0.479

High

258182

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.479

High

258186

RC3H2
Roquin-2

1

4

High-throughput

0.479

High

258187

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.479

High

258188

ANLN
Anillin

1

1

High-throughput

0.479

High

258189

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

258194

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

258196

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.479

High

258197

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

258198

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

258034

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.470

High

258065

THB
Thyroid hormone receptor beta

1

9

High-throughput

0.470

High

128660

MEN1
Menin

1

0

High-throughput

0.458

High

223477

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

0

High-throughput

0.458

High

247551

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

258021

CPNE3
Copine-3

1

0

High-throughput

0.458

High

258030

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

258051

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.458

High

258052

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

258083

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

258101

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

258123

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

258136

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

258142

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

258151

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

258153

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

258157

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

258162

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.458

High

258170

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

258174

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

258181

RWDD1
RWD domain-containing protein 1

1

0

High-throughput

0.458

High

258193

PLK2
Serine/threonine-protein kinase PLK2

1

0

High-throughput

0.458

High

258195

CRNN
Cornulin

1

0

High-throughput

0.458

High

258201

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

258103

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

1

Small-scale

0.457

High

184544

MK13
Mitogen-activated protein kinase 13

1

10

Small-scale

0.445

High

258048

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

258112

NCBP1
Nuclear cap-binding protein subunit 1

1

1

High-throughput

0.445

High

258121

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.445

High

258124

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

258140

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

258175

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.445

High

258147

PAXI1
PAX-interacting protein 1

1

2

High-throughput

0.439

High

258098

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.438

High

258020

LIRB5
Leukocyte immunoglobulin-like receptor subfamily B member 5

1

1

High-throughput

0.437

High

258037

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

258042

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.437

High

258044

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

258053

NFM
Neurofilament medium polypeptide

1

1

High-throughput

0.437

High

258056

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.437

High

258062

H2A1
Histone H2A type 1

1

5

High-throughput

0.437

High

258068

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

258072

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

258079

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

258084

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

258094

CAD15
Cadherin-15

1

1

High-throughput

0.437

High

258118

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.437

High

258132

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.437

High

258144

LRC31
Leucine-rich repeat-containing protein 31

1

3

High-throughput

0.437

High

258169

H2B1A
Histone H2B type 1-A

1

3

High-throughput

0.437

High

258177

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.437

High

258192

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

258199

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.437

High

258200

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.437

High

258035

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

258043

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

258049

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

258126

BECN1
Beclin-1

1

0

High-throughput

0.426

High

258046

IPSP
Plasma serine protease inhibitor

1

1

Small-scale

0.407

High

258104

CBX1
Chromobox protein homolog 1

1

2

Small-scale

0.407

High

258138

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

1

High-throughput

0.407

High

258158

SVOPL
Putative transporter SVOPL

1

2

High-throughput

0.407

High

258086

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.373

High

178594

DEGS1
Sphingolipid delta(4)-desaturase DES1

2

0

High-throughput

0.313

High

258180

RASF4
Ras association domain-containing protein 4

2

0

High-throughput

0.305

High

258026

WFS1
Wolframin

1

0

High-throughput

0.268

Low

193917

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

258070

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

258145

DYH12
Dynein axonemal heavy chain 12

1

0

High-throughput

0.249

Low

258150

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

258152

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.249

Low

258163

OR8B3
Olfactory receptor 8B3

1

0

High-throughput

0.249

Low

258184

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.249

Low

258202

TIM9
Mitochondrial import inner membrane translocase subunit Tim9

1

0

High-throughput

0.249

Low

62428

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

258135

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

258148

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

258159

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

258171

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low

258173

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025