Protein: SYAC
Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) (Renal carcinoma antigen NY-REN-42)

Gene: SYAC, AARS1
Organism: Homo sapiens
Interactions: 127
UniProt ID: P49588

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0002196 - Ser-tRNA(Ala) deacylase activity
GO:0004813 - alanine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

529339

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.601

High

619610

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

241075

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

884508

RAC1
Ras-related C3 botulinum toxin substrate 1

2

3

High-throughput

0.571

High

884527

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

389154

FINC
Fibronectin

1

3

High-throughput

0.536

High

468176

HS90B
Heat shock protein HSP 90-beta

1

6

Small-scale

0.536

High

563418

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

884497

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

884543

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

884559

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

105566

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

884499

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

0

High-throughput

0.518

High

221545

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.515

High

361166

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

884521

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.513

High

884539

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

884500

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

884503

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

134606

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.493

High

884555

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

157096

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

227428

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

259619

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

371465

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

411572

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

413407

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

461269

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

562573

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.479

High

565232

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

577414

ETS1
Protein C-ets-1

1

1

High-throughput

0.479

High

588186

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606421

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

618496

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

5

High-throughput

0.479

High

667645

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

694909

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

730449

1433S
14-3-3 protein sigma

1

4

High-throughput

0.479

High

798844

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

828629

MDHC
Malate dehydrogenase, cytoplasmic

1

3

High-throughput

0.479

High

830338

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

883171

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

884496

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

884502

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

884504

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

884505

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

884506

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.479

High

884507

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.479

High

884509

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

884514

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

884515

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

884516

CUL3
Cullin-3

1

3

High-throughput

0.479

High

884518

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

884519

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

884520

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

884522

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

884523

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

884530

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

884532

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

884534

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

884538

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

884541

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

884547

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

884548

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

884549

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

884550

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

884553

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

884554

OPTN
Optineurin

1

3

High-throughput

0.479

High

884557

AURKB
Aurora kinase B

1

2

High-throughput

0.479

High

884560

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

884565

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

884567

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

884570

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

884575

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

884576

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

222825

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

290895

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

417318

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

560327

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

603893

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

884501

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

884510

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

884524

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

884525

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

884528

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

884535

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

884536

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.458

High

884540

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

884542

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

884552

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

884561

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

884562

MICU1
Calcium uptake protein 1, mitochondrial

1

0

High-throughput

0.458

High

884566

PININ
Pinin

1

0

High-throughput

0.458

High

884569

SPTN5
Spectrin beta chain, non-erythrocytic 5

1

0

High-throughput

0.458

High

884573

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

884571

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

142303

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

884498

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

884511

TAGL
Transgelin

1

2

High-throughput

0.445

High

884544

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

2

High-throughput

0.445

High

884556

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

884558

SYMM
Methionine--tRNA ligase, mitochondrial

1

6

High-throughput

0.445

High

884568

ITM2C
Integral membrane protein 2C

1

3

High-throughput

0.445

High

884572

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

884577

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

884512

MEF2C
Myocyte-specific enhancer factor 2C

1

0

High-throughput

0.438

High

239772

PCDH7
Protocadherin-7

1

1

High-throughput

0.437

High

353105

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

653766

MRC1
Macrophage mannose receptor 1

1

4

High-throughput

0.437

High

767682

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

884517

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

884526

ANR55
Ankyrin repeat domain-containing protein 55

1

3

High-throughput

0.437

High

884531

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

884533

KCTD9
BTB/POZ domain-containing protein KCTD9

1

2

High-throughput

0.437

High

884546

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

884574

HACD3
Very-long-chain

1

2

High-throughput

0.437

High

884578

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

884513

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

884537

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

884545

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.426

High

884551

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

884563

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

884564

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

884495

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

330076

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

689808

CD27
CD27 antigen

1

2

High-throughput

0.407

High

884529

Q6NSK7
RIN3 protein

1

0

High-throughput

0.238

Low

884579

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025