Protein: TIM44
Mitochondrial import inner membrane translocase subunit TIM44

Gene: TIM44, TIMM44
Organism: Homo sapiens
Interactions: 229
UniProt ID: O43615

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005744 - TIM23 mitochondrial import inner membrane translocase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

221647

TI17A
Mitochondrial import inner membrane translocase subunit Tim17-A

1

1

Small-scale

0.618

High

221513

ARAF
Serine/threonine-protein kinase A-Raf

2

1

Small-scale

0.595

High

221537

HSPA9
Stress-70 protein, mitochondrial

2

3

Small-scale

0.595

High

221497

CO1A1
Collagen alpha-1(I) chain

2

2

High-throughput

0.574

High

221507

CO1A2
Collagen alpha-2(I) chain

2

2

High-throughput

0.574

High

221524

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

221479

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

221483

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

221492

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

221518

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

221571

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

221587

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

221674

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

221504

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

221564

TIE2
Angiopoietin-1 receptor

1

5

High-throughput

0.536

High

221545

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

221697

TF3C3
General transcription factor 3C polypeptide 3

1

1

High-throughput

0.515

High

221495

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

221664

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

221498

CO3A1

1

2

High-throughput

0.489

High

221696

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.489

High

221481

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.479

High

221484

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

221486

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

221500

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

221501

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

221502

ADT2
ADP/ATP translocase 2

1

3

Small-scale

0.479

High

221506

IGF1R
Insulin-like growth factor 1 receptor

1

5

High-throughput

0.479

High

221509

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

4

High-throughput

0.479

High

221515

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

221516

FGFR1
Fibroblast growth factor receptor 1

1

6

High-throughput

0.479

High

221517

ADT1
ADP/ATP translocase 1

1

3

Small-scale

0.479

High

221523

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.479

High

221526

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.479

High

221531

UFO
Tyrosine-protein kinase receptor UFO

1

5

High-throughput

0.479

High

221534

VGFR3
Vascular endothelial growth factor receptor 3

1

4

High-throughput

0.479

High

221535

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

221536

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.479

High

221541

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

221547

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

221570

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

221572

MERTK
Tyrosine-protein kinase Mer

1

5

High-throughput

0.479

High

221573

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

221582

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

221588

DDR2
Discoidin domain-containing receptor 2

1

4

High-throughput

0.479

High

221592

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

221600

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

221602

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.479

High

221603

LMTK1
Serine/threonine-protein kinase LMTK1

1

6

High-throughput

0.479

High

221609

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

221613

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

221618

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

221619

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.479

High

221620

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.479

High

221622

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

1

High-throughput

0.479

High

221626

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

221627

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

221628

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

221631

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

221632

COQ8B
Atypical kinase COQ8B, mitochondrial

1

1

High-throughput

0.479

High

221633

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

3

High-throughput

0.479

High

221638

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

221643

LMTK3
Serine/threonine-protein kinase LMTK3

1

9

High-throughput

0.479

High

221645

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

221654

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

221663

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

221665

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

221668

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

221669

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

221680

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

221685

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

221689

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

221695

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

1

Small-scale

0.479

High

221698

DJC15
DnaJ homolog subfamily C member 15

1

3

High-throughput

0.479

High

221699

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.479

High

221561

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.470

High

61364

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66088

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

137567

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

183544

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

221482

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

221485

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

221487

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

221493

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

221494

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

221508

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

221511

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

221512

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

221519

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

221520

EZRI
Ezrin

1

0

High-throughput

0.458

High

221529

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

221538

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

221539

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

221540

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

221543

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

221544

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

221554

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

221560

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

221563

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

221566

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

221567

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

221568

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

221578

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

221580

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

221584

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

221586

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

221597

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

221601

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

221606

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

221607

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

221608

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

221611

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.458

High

221621

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

221630

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

221634

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

221636

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

221637

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

221640

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

221644

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

221646

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

221650

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

221651

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

221652

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

221653

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

221655

TR61B
tRNA

1

0

High-throughput

0.458

High

221656

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

221657

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.458

High

221660

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

221661

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

221662

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

221666

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

221667

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

221672

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

221673

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

221675

NGRN
Neugrin

1

0

High-throughput

0.458

High

221678

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

221679

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

221681

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

221682

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

221684

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

221687

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

221694

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

221585

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.445

High

221480

H2B1K
Histone H2B type 1-K

1

5

High-throughput

0.437

High

221528

H2B1O
Histone H2B type 1-O

1

5

High-throughput

0.437

High

221546

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.437

High

221548

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.437

High

221550

H2B1D
Histone H2B type 1-D

1

5

High-throughput

0.437

High

221552

RHOA
Transforming protein RhoA

1

1

High-throughput

0.437

High

221553

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

221557

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.437

High

221559

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

221575

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

2

High-throughput

0.437

High

221583

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

221604

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

221623

H2B1H
Histone H2B type 1-H

1

5

High-throughput

0.437

High

221624

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.437

High

221649

H2B1L
Histone H2B type 1-L

1

5

High-throughput

0.437

High

221658

RNF26
E3 ubiquitin-protein ligase RNF26

1

1

High-throughput

0.437

High

221693

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.437

High

851

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

221514

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

221527

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

221595

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

221648

OSMR
Oncostatin-M-specific receptor subunit beta

1

1

Small-scale

0.407

High

221635

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.341

High

221692

UBQL2
Ubiquilin-2

2

0

Small-scale

0.325

High

221490

SFT2B
Vesicle transport protein SFT2B

2

0

High-throughput

0.316

High

221549

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

0

High-throughput

0.316

High

221590

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

209392

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

221505

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.279

Low

221610

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

221581

OPCM
Opioid-binding protein/cell adhesion molecule

1

0

High-throughput

0.269

Low

221593

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.269

Low

221562

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

221489

PRP6
Pre-mRNA-processing factor 6

1

0

Small-scale

0.251

Low

179760

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

217556

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

221488

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

221496

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

221499

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

221503

LA
Lupus La protein

1

0

High-throughput

0.249

Low

221510

H2A1
Histone H2A type 1

1

0

High-throughput

0.249

Low

221521

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

221522

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

221525

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

221530

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

221532

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.249

Low

221533

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

221542

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

221555

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

221556

H4
Histone H4

1

0

High-throughput

0.249

Low

221558

H31
Histone H3.1

1

0

High-throughput

0.249

Low

221565

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.249

Low

221569

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.249

Low

221574

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

221576

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

221577

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

221579

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

221589

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

221591

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

221596

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

221598

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

221599

ZN746
Zinc finger protein 746

1

0

High-throughput

0.249

Low

221605

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.249

Low

221615

NIN
Ninein

1

0

High-throughput

0.249

Low

221616

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

221617

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

221625

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

221629

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low

221639

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

221641

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

221642

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

221659

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

221670

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

221671

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

221676

ANLN
Anillin

1

0

High-throughput

0.249

Low

221677

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

221683

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

221686

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

221690

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

221691

TES
Testin

1

0

High-throughput

0.249

Low

221491

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

221551

CD81
CD81 antigen

1

0

High-throughput

0.232

Low

221594

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.232

Low

221612

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.232

Low

221614

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

221688

VGLU2
Vesicular glutamate transporter 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025