Protein: ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6 (GPC-Cpde) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 6) (E-NPP 6) (NPP-6)

Gene: ENPP6
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q6UWR7

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0006629 - lipid metabolic process
GO:0008081 - phosphoric diester hydrolase activity
GO:0008889 - glycerophosphodiester phosphodiesterase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

178796

SCAM1
Secretory carrier-associated membrane protein 1

4

1

High-throughput

0.691

High

189650

STX7
Syntaxin-7

3

1

High-throughput

0.667

High

1225886

STEA3
Metalloreductase STEAP3

3

0

High-throughput

0.638

High

1248821

KAISO
Transcriptional regulator Kaiso

3

0

High-throughput

0.638

High

1248823

CRLF3
Cytokine receptor-like factor 3

3

0

High-throughput

0.638

High

1248835

S26A6
Solute carrier family 26 member 6

3

0

High-throughput

0.638

High

1154655

VAMP3
Vesicle-associated membrane protein 3

2

2

High-throughput

0.611

High

1248818

MEX3B
RNA-binding protein MEX3B

3

1

High-throughput

0.609

High

1248845

MKS1
Tectonic-like complex member MKS1

3

1

High-throughput

0.609

High

1247355

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.602

High

1248825

GLBL2
Beta-galactosidase-1-like protein 2

2

0

High-throughput

0.585

High

1248844

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

2

0

High-throughput

0.585

High

1248838

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

3

2

High-throughput

0.585

High

1086018

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

1248850

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

1

High-throughput

0.574

High

611183

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

1

High-throughput

0.558

High

1248833

LMF2
Lipase maturation factor 2

2

1

High-throughput

0.558

High

1248846

TOR4A
Torsin-4A

1

2

High-throughput

0.536

High

1034006

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.458

High

1248836

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.458

High

1248840

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.458

High

943976

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

180850

TIF1A
Transcription intermediary factor 1-alpha

1

4

High-throughput

0.437

High

1248830

LMF1
Lipase maturation factor 1

1

1

High-throughput

0.437

High

1248824

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.426

High

1248826

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.426

High

1248829

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.426

High

1248822

MEX3D
RNA-binding protein MEX3D

1

1

High-throughput

0.407

High

1248832

Q96T11
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.407

High

328377

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

4

0

High-throughput

0.360

High

1248851

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

4

0

High-throughput

0.360

High

183155

GNPAT
Dihydroxyacetone phosphate acyltransferase

3

0

High-throughput

0.347

High

223626

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

3

0

High-throughput

0.347

High

223731

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

3

0

High-throughput

0.347

High

397743

NU5M
NADH-ubiquinone oxidoreductase chain 5

3

0

High-throughput

0.347

High

1248820

TEDC1
Tubulin epsilon and delta complex protein 1

3

0

High-throughput

0.347

High

1248827

GLMN
Glomulin

3

0

High-throughput

0.347

High

1248828

RUND1
RUN domain-containing protein 1

3

0

High-throughput

0.347

High

1248839

ALG9
Alpha-1,2-mannosyltransferase ALG9

3

0

High-throughput

0.347

High

1248843

DIAP3
Protein diaphanous homolog 3

3

0

High-throughput

0.347

High

1248847

SACS
Sacsin

3

0

High-throughput

0.347

High

328544

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

3

0

High-throughput

0.339

High

328310

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

2

0

High-throughput

0.318

High

1248834

NUP85
Nuclear pore complex protein Nup85

2

0

High-throughput

0.318

High

1248848

EMC3
ER membrane protein complex subunit 3

2

0

High-throughput

0.318

High

106134

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

215585

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.249

Low

1248819

TMTC3
Protein O-mannosyl-transferase TMTC3

1

0

High-throughput

0.249

Low

1248831

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.249

Low

1248841

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.249

Low

1248842

PYRG2
CTP synthase 2

1

0

High-throughput

0.249

Low

209783

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.232

Low

733873

DCTD
Deoxycytidylate deaminase

1

0

High-throughput

0.232

Low

1248837

TM245
Transmembrane protein 245

1

0

High-throughput

0.232

Low

1248849

TRI10
Tripartite motif-containing protein 10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025