Protein: PACC1
Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206)

Gene: PACC1
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q9H813

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006821 - chloride transport
GO:0009986 - cell surface
GO:0034707 - chloride channel complex
GO:0061797 - pH-gated chloride channel activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1415441

TM147
BOS complex subunit TMEM147

4

0

High-throughput

0.669

High

1219092

DAB2P
Disabled homolog 2-interacting protein

3

0

High-throughput

0.634

High

1413675

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

3

0

High-throughput

0.634

High

1421251

TTYH3
Protein tweety homolog 3

3

0

High-throughput

0.634

High

333518

MPZL1
Myelin protein zero-like protein 1

2

1

High-throughput

0.628

High

931299

AT12A
Potassium-transporting ATPase alpha chain 2

2

1

High-throughput

0.628

High

959403

RAP1B
Ras-related protein Rap-1b

2

1

High-throughput

0.628

High

1119890

CKAP5
Cytoskeleton-associated protein 5

2

1

High-throughput

0.628

High

1332668

MIGA1
Mitoguardin 1

2

1

High-throughput

0.628

High

380357

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

1

High-throughput

0.611

High

1436021

PLLP
Plasmolipin

2

1

High-throughput

0.606

High

1095943

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

3

High-throughput

0.604

High

1216529

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

3

1

High-throughput

0.604

High

1349334

TBC15
TBC1 domain family member 15

3

2

High-throughput

0.604

High

1421102

XPO4
Exportin-4

3

1

High-throughput

0.604

High

1435996

EI2BG
Translation initiation factor eIF2B subunit gamma

3

1

High-throughput

0.604

High

1436012

EI2BD
Translation initiation factor eIF2B subunit delta

3

2

High-throughput

0.604

High

1436026

5MP1
eIF5-mimic protein 1

3

2

High-throughput

0.604

High

839372

MTOR
Serine/threonine-protein kinase mTOR

2

0

High-throughput

0.602

High

897607

KNTC1
Kinetochore-associated protein 1

2

0

High-throughput

0.602

High

1154748

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.602

High

1390882

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.602

High

1435994

RAB9B
Ras-related protein Rab-9B

2

0

High-throughput

0.602

High

1023393

AT2C1
Calcium-transporting ATPase type 2C member 1

2

1

High-throughput

0.601

High

1050061

PLP2
Proteolipid protein 2

2

0

High-throughput

0.580

High

251254

RNBP6
Ran-binding protein 6

2

4

High-throughput

0.574

High

334909

IPO7
Importin-7

2

7

High-throughput

0.574

High

934169

XPO2
Exportin-2

2

7

High-throughput

0.574

High

1144737

PWP2
Periodic tryptophan protein 2 homolog

2

3

High-throughput

0.574

High

1158083

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

2

1

High-throughput

0.574

High

1258000

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

2

1

High-throughput

0.574

High

1271311

5MP2
eIF5-mimic protein 2

2

2

High-throughput

0.574

High

1399498

IPO9
Importin-9

2

6

High-throughput

0.574

High

1436013

IPO11
Importin-11

2

6

High-throughput

0.574

High

1436014

XPO7
Exportin-7

2

2

High-throughput

0.574

High

1436018

WDR3
WD repeat-containing protein 3

2

1

High-throughput

0.574

High

1436022

RBGP1
Rab GTPase-activating protein 1

2

2

High-throughput

0.574

High

1436023

TNPO3
Transportin-3

2

5

High-throughput

0.574

High

164643

TNPO2
Transportin-2

2

6

High-throughput

0.558

High

890164

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

High-throughput

0.549

High

1435993

AT131
Endoplasmic reticulum transmembrane helix translocase

2

2

High-throughput

0.549

High

374199

RASN
GTPase NRas

1

1

High-throughput

0.536

High

565712

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.536

High

607991

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.536

High

851221

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.536

High

984281

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

178658

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.513

High

189846

STX7
Syntaxin-7

1

0

High-throughput

0.513

High

827928

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.513

High

1125928

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

High-throughput

0.513

High

1253800

QSOX2
Sulfhydryl oxidase 2

1

0

High-throughput

0.513

High

1066025

VAC14
Protein VAC14 homolog

1

5

High-throughput

0.489

High

1371008

TNPO1
Transportin-1

1

6

High-throughput

0.489

High

1435991

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

1

High-throughput

0.489

High

658536

GLRA2
Glycine receptor subunit alpha-2

1

1

High-throughput

0.479

High

1192293

ZACN
Ligand-gated cation channel ZACN

1

3

High-throughput

0.479

High

1360207

5HT3C
5-hydroxytryptamine receptor 3C

1

2

High-throughput

0.479

High

133799

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

218787

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

521011

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.458

High

967355

TSN5
Tetraspanin-5

1

0

High-throughput

0.458

High

1248840

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.458

High

1351234

MCLN3
Mucolipin-3

1

0

High-throughput

0.458

High

1124233

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.445

High

1143909

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

High-throughput

0.445

High

1272095

MIGA2
Mitoguardin 2

1

1

High-throughput

0.445

High

1435999

TEN2
Teneurin-2

1

1

High-throughput

0.445

High

1436003

SCN3B
Sodium channel regulatory subunit beta-3

1

1

High-throughput

0.445

High

1436004

TEN3
Teneurin-3

1

1

High-throughput

0.445

High

1093578

TRDN
Triadin

1

0

High-throughput

0.426

High

1103797

PLD1
Phospholipase D1

1

0

High-throughput

0.426

High

1154077

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.426

High

1316118

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.426

High

1333500

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.426

High

1339287

RAI3
Retinoic acid-induced protein 3

1

0

High-throughput

0.426

High

1364183

RGP1
RAB6A-GEF complex partner protein 2

1

0

High-throughput

0.426

High

1435988

EVA1A
Protein eva-1 homolog A

1

0

High-throughput

0.426

High

1436001

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.426

High

1436006

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.426

High

134156

IPO5
Importin-5

1

4

High-throughput

0.407

High

404428

GCR
Glucocorticoid receptor

1

1

High-throughput

0.407

High

1195638

Q4LE60
TNPO2 variant protein

1

6

High-throughput

0.407

High

1226425

TBC9B
TBC1 domain family member 9B

1

1

High-throughput

0.407

High

1351314

DMXL2
DmX-like protein 2

1

2

High-throughput

0.407

High

1435990

TBC17
TBC1 domain family member 17

1

2

High-throughput

0.407

High

337818

SGPL1
Sphingosine-1-phosphate lyase 1

3

0

High-throughput

0.345

High

1239827

MZT2B
Mitotic-spindle organizing protein 2B

3

0

High-throughput

0.345

High

1251559

THADA
tRNA

3

0

High-throughput

0.345

High

1278637

HEAT3
HEAT repeat-containing protein 3

3

0

High-throughput

0.345

High

1287780

NOP9
Nucleolar protein 9

3

0

High-throughput

0.345

High

1327965

CISD2
CDGSH iron-sulfur domain-containing protein 2

3

0

High-throughput

0.345

High

1383473

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

3

0

High-throughput

0.345

High

1389594

SAAL1
Protein SAAL1

3

0

High-throughput

0.345

High

1436007

COMD3
COMM domain-containing protein 3

3

0

High-throughput

0.345

High

183180

GNPAT
Dihydroxyacetone phosphate acyltransferase

2

0

High-throughput

0.328

High

320059

UFL1
E3 UFM1-protein ligase 1

2

0

High-throughput

0.328

High

665146

COT2
COUP transcription factor 2

2

0

High-throughput

0.328

High

884476

PCY1A
Choline-phosphate cytidylyltransferase A

2

0

High-throughput

0.328

High

922778

CCHL
Holocytochrome c-type synthase

2

0

High-throughput

0.328

High

1140873

KIF14
Kinesin-like protein KIF14

2

0

High-throughput

0.328

High

1238606

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.328

High

1329734

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

0

High-throughput

0.328

High

1363853

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

0

High-throughput

0.328

High

1371196

GLMN
Glomulin

2

0

High-throughput

0.328

High

1381725

FAKD4
FAST kinase domain-containing protein 4

2

0

High-throughput

0.328

High

1394798

CK5P3
CDK5 regulatory subunit-associated protein 3

2

0

High-throughput

0.328

High

1398186

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

2

0

High-throughput

0.328

High

1399748

RBM14
RNA-binding protein 14

2

0

High-throughput

0.328

High

1412535

GCP2
Gamma-tubulin complex component 2

2

0

High-throughput

0.328

High

1413514

DCNL5
DCN1-like protein 5

2

0

High-throughput

0.328

High

1430293

TM222
Transmembrane protein 222

2

0

High-throughput

0.328

High

1435989

ZWILC
Protein zwilch homolog

2

0

High-throughput

0.328

High

1435992

RDH14
Retinol dehydrogenase 14

2

0

High-throughput

0.328

High

1435997

F1142
Protein FAM114A2

2

0

High-throughput

0.328

High

1436002

TM38B
Trimeric intracellular cation channel type B

2

0

High-throughput

0.328

High

1436009

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.328

High

1436010

ARMX3
Armadillo repeat-containing X-linked protein 3

2

0

High-throughput

0.328

High

1436019

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

0

High-throughput

0.328

High

1436025

MTCH2
Mitochondrial carrier homolog 2

2

0

High-throughput

0.328

High

1195550

CTXN3
Cortexin-3

2

0

High-throughput

0.316

High

1394453

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

1234004

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

2

0

High-throughput

0.313

High

1436000

SAC1
Phosphatidylinositol-3-phosphatase SAC1

2

0

High-throughput

0.313

High

257676

PRAF2
PRA1 family protein 2

1

0

High-throughput

0.279

Low

291539

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.279

Low

699137

CALX
Calnexin

1

0

High-throughput

0.279

Low

847447

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

940185

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.279

Low

1085289

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.279

Low

1243103

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1253827

MMS22
Protein MMS22-like

1

0

High-throughput

0.279

Low

1309555

NNRD
ATP-dependent

1

0

High-throughput

0.279

Low

1315994

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1324313

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.279

Low

1358305

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.279

Low

1393700

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.279

Low

1409663

CND3
Condensin complex subunit 3

1

0

High-throughput

0.279

Low

1255565

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1334566

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.249

Low

1436017

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

0

High-throughput

0.249

Low

136551

GOLI4
Golgi integral membrane protein 4

1

0

High-throughput

0.232

Low

316569

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.232

Low

350415

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

High-throughput

0.232

Low

351172

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.232

Low

638140

AOFA
Amine oxidase [flavin-containing] A

1

0

High-throughput

0.232

Low

828448

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.232

Low

994957

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.232

Low

1091984

SEC20
Vesicle transport protein SEC20

1

0

High-throughput

0.232

Low

1136166

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.232

Low

1147568

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.232

Low

1194015

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.232

Low

1325342

PHTF2
Protein PHTF2

1

0

High-throughput

0.232

Low

1325734

ZN843
Zinc finger protein 843

1

0

High-throughput

0.232

Low

1359107

TMM40
Transmembrane protein 40

1

0

High-throughput

0.232

Low

1368433

SC65
Endoplasmic reticulum protein SC65

1

0

High-throughput

0.232

Low

1397983

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

1404213

SEC62
Translocation protein SEC62

1

0

High-throughput

0.232

Low

1416005

NUDT9
ADP-ribose pyrophosphatase, mitochondrial

1

0

High-throughput

0.232

Low

1435995

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.232

Low

1435998

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.232

Low

1436005

STX18
Syntaxin-18

1

0

High-throughput

0.232

Low

1436008

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.232

Low

1436011

BAP29
B-cell receptor-associated protein 29

1

0

High-throughput

0.232

Low

1436015

FBX2
F-box only protein 2

1

0

High-throughput

0.232

Low

1436016

KDIS
Kinase D-interacting substrate of 220 kDa

1

0

High-throughput

0.232

Low

1436020

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.232

Low

1436024

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025