Protein: NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)

Gene: NDUB5, NDUFB5
Organism: Homo sapiens
Interactions: 110
UniProt ID: O43674

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006120 - mitochondrial electron transport, NADH to ubiquinone
GO:0008137 - NADH dehydrogenase (ubiquinone) activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

223586

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

7

2

High-throughput

0.958

High

223594

NU5M
NADH-ubiquinone oxidoreductase chain 5

3

2

High-throughput

0.855

High

223593

NU4M
NADH-ubiquinone oxidoreductase chain 4

2

2

High-throughput

0.811

High

223582

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

3

0

High-throughput

0.811

High

223589

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

3

0

High-throughput

0.811

High

223661

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

3

0

High-throughput

0.811

High

223574

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

2

0

High-throughput

0.770

High

223580

NDUB1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

2

0

High-throughput

0.770

High

223592

NU2M
NADH-ubiquinone oxidoreductase chain 2

1

2

High-throughput

0.691

High

223610

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

1

High-throughput

0.667

High

223581

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

4

0

High-throughput

0.664

High

223646

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

3

0

High-throughput

0.638

High

223571

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

3

0

High-throughput

0.634

High

223584

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

3

0

High-throughput

0.634

High

223623

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

3

0

High-throughput

0.634

High

223663

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

3

0

High-throughput

0.634

High

223671

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

3

0

High-throughput

0.634

High

223643

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

3

0

High-throughput

0.622

High

97142

NDUCR
NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2

1

2

High-throughput

0.618

High

223577

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

223579

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

0

High-throughput

0.602

High

223598

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.602

High

223604

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

2

0

High-throughput

0.602

High

223640

HDA10
Polyamine deacetylase HDAC10

2

0

High-throughput

0.602

High

223655

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

0

High-throughput

0.602

High

223658

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.602

High

223665

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

2

0

High-throughput

0.602

High

223670

CIA30
Complex I intermediate-associated protein 30, mitochondrial

2

0

High-throughput

0.602

High

223628

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

2

0

High-throughput

0.585

High

223662

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

2

0

High-throughput

0.585

High

223599

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

2

0

High-throughput

0.576

High

223614

PSME3
Proteasome activator complex subunit 3

2

0

High-throughput

0.576

High

223650

PIP30
PSME3-interacting protein

2

0

High-throughput

0.576

High

223572

ITM2A
Integral membrane protein 2A

2

1

High-throughput

0.574

High

223602

NK1R
Substance-P receptor

2

1

High-throughput

0.574

High

223621

C3AR
C3a anaphylatoxin chemotactic receptor

2

1

High-throughput

0.574

High

223595

ETS2
Protein C-ets-2

1

0

High-throughput

0.518

High

127429

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

0

High-throughput

0.513

High

183789

NDUA1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

1

0

High-throughput

0.513

High

223576

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

223578

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.513

High

223583

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.513

High

223585

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.513

High

223591

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.513

High

223611

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.513

High

223622

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.513

High

223629

T126B
Complex I assembly factor TMEM126B, mitochondrial

1

0

High-throughput

0.513

High

223630

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

223637

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

223648

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.513

High

223656

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.513

High

223659

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

165867

FFAR1
Free fatty acid receptor 1

1

1

High-throughput

0.489

High

223642

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.489

High

223667

GPR34
Probable G-protein coupled receptor 34

1

1

High-throughput

0.489

High

137568

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

223588

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

223597

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

223603

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

223605

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

223617

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

223636

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

223641

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

223644

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.458

High

223652

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.458

High

223653

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

223657

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

223664

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

223618

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.445

High

156409

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.426

High

223612

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

Small-scale

0.426

High

223651

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.426

High

223634

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

223668

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

223626

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

3

0

High-throughput

0.347

High

223600

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

2

0

High-throughput

0.328

High

223615

NCALD
Neurocalcin-delta

2

0

High-throughput

0.328

High

223632

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

2

0

High-throughput

0.328

High

223647

PSMG3
Proteasome assembly chaperone 3

2

0

High-throughput

0.328

High

223649

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

223613

SCND1
SCAN domain-containing protein 1

2

0

High-throughput

0.316

High

223590

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

219257

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

223573

EXTL3
Exostosin-like 3

1

0

High-throughput

0.279

Low

223575

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.279

Low

223587

VNN2
Pantetheine hydrolase VNN2

1

0

High-throughput

0.279

Low

223606

OPRX
Nociceptin receptor

1

0

High-throughput

0.279

Low

223607

CXA8
Gap junction alpha-8 protein

1

0

High-throughput

0.279

Low

223608

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.279

Low

223609

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.279

Low

223619

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.279

Low

223625

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.279

Low

223633

T185A
Transmembrane protein 185A

1

0

High-throughput

0.279

Low

223635

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

223638

NICA
Nicastrin

1

0

High-throughput

0.279

Low

223639

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.279

Low

223645

SORT
Sortilin

1

0

High-throughput

0.279

Low

223654

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

223660

TM140
Transmembrane protein 140

1

0

High-throughput

0.279

Low

223666

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low

104898

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

223627

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

223631

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

58765

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

223596

RAC2
Ras-related C3 botulinum toxin substrate 2

1

0

High-throughput

0.232

Low

223601

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.232

Low

223616

LYSC
Lysozyme C

1

0

High-throughput

0.232

Low

223620

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

223624

Q17RG0
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

223669

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025