Protein: NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)

Gene: NDUS4, NDUFS4
Organism: Homo sapiens
Interactions: 155
UniProt ID: O43181

Gene Ontology (top 5):
GO:0001932 - regulation of protein phosphorylation
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006120 - mitochondrial electron transport, NADH to ubiquinone
GO:0007420 - brain development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

209718

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

6

1

High-throughput

0.947

High

209740

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

3

0

High-throughput

0.811

High

209777

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

3

0

High-throughput

0.811

High

209759

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

2

0

High-throughput

0.770

High

209847

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

2

0

High-throughput

0.770

High

127427

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

1

High-throughput

0.691

High

209760

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

4

1

Small-scale

0.672

High

209842

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

4

0

High-throughput

0.667

High

209743

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.656

High

209753

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.656

High

209810

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

3

1

High-throughput

0.650

High

209757

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

0

High-throughput

0.638

High

209788

PRRT2
Proline-rich transmembrane protein 2

4

1

High-throughput

0.630

High

209715

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

1

High-throughput

0.628

High

209723

VAPB
Vesicle-associated membrane protein-associated protein B/C

3

1

High-throughput

0.604

High

209711

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

2

0

High-throughput

0.602

High

209713

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

209721

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

2

0

High-throughput

0.602

High

209722

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

2

0

High-throughput

0.602

High

209840

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

2

0

High-throughput

0.602

High

209791

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.585

High

209724

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

2

0

High-throughput

0.576

High

209770

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

209776

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

209714

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

High-throughput

0.536

High

209731

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

1

High-throughput

0.536

High

209732

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

High-throughput

0.536

High

156178

CO72L
Cytochrome c oxidase subunit 7A2-like, mitochondrial

1

0

High-throughput

0.513

High

183788

NDUA1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

1

0

High-throughput

0.513

High

209708

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.513

High

209709

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.513

High

209720

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

High-throughput

0.513

High

209726

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.513

High

209730

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.513

High

209739

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.513

High

209790

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.513

High

209750

CXA8
Gap junction alpha-8 protein

1

1

High-throughput

0.489

High

209797

AQP3
Aquaporin-3

1

1

High-throughput

0.489

High

209809

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.489

High

209843

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.489

High

209733

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

209712

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

209716

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

209717

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

209719

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

209749

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

209768

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

209787

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

209793

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

209798

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

209799

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

209802

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

209813

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

209824

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

209828

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

209838

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

209841

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

209845

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

61362

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66085

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

137565

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

183542

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

209725

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

209727

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

209736

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

209737

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

209738

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.458

High

209745

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

209746

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

209747

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

209748

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

209752

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

209764

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

209765

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

209766

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

209767

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

209771

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

209772

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

209774

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

209775

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

209780

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

209782

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

209785

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

209786

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

209803

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

209804

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.458

High

209805

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

209806

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

209808

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

209812

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

209814

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

209815

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

209816

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

209817

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

209818

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

209819

TR61B
tRNA

1

0

High-throughput

0.458

High

209820

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

209821

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

209823

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

209825

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.458

High

209826

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

209827

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

209829

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

209831

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

209832

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

209833

NGRN
Neugrin

1

0

High-throughput

0.458

High

209836

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

209837

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

209839

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

209844

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

209851

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

209735

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

209754

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.426

High

209795

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

209796

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

3

0

High-throughput

0.345

High

209741

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

2

0

High-throughput

0.328

High

209742

IL1R2
Interleukin-1 receptor type 2

2

0

High-throughput

0.328

High

209792

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

2

0

High-throughput

0.328

High

209822

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

209729

ESR1
Estrogen receptor

2

0

High-throughput

0.298

High

209761

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.282

High

165866

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

209710

EXTL3
Exostosin-like 3

1

0

High-throughput

0.279

Low

209734

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

209751

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.279

Low

209756

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.279

Low

209758

EMP3
Epithelial membrane protein 3

1

0

High-throughput

0.279

Low

209779

STUM
Protein stum homolog

1

0

High-throughput

0.279

Low

209811

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

209835

TSH2
Teashirt homolog 2

1

0

High-throughput

0.279

Low

209848

GPR34
Probable G-protein coupled receptor 34

1

0

High-throughput

0.279

Low

209852

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

209853

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

209728

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

209744

CTNB1
Catenin beta-1

1

0

High-throughput

0.249

Low

209755

BAP31
B-cell receptor-associated protein 31

1

0

Small-scale

0.249

Low

209762

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

209763

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

209778

MIDN
Midnolin

1

0

High-throughput

0.249

Low

209784

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

209789

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.249

Low

209830

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

209846

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

171815

ZN263
Zinc finger protein 263

1

0

High-throughput

0.232

Low

209769

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.232

Low

209773

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

209781

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

209783

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

1

0

High-throughput

0.232

Low

209794

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.232

Low

209800

EMID1
EMI domain-containing protein 1

1

0

High-throughput

0.232

Low

209801

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.232

Low

209807

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

209834

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.232

Low

209849

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low

209850

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025