Protein: BID
BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]

Gene: BID
Organism: Homo sapiens
Interactions: 122
UniProt ID: P55957

Gene Ontology (top 5):
GO:0001836 - release of cytochrome c from mitochondria
GO:0005123 - death receptor binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

939616

B2CL1
Bcl-2-like protein 1

10

10

Small-scale

0.973

High

939617

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

7

10

Small-scale

0.970

High

522067

BCL2
Apoptosis regulator Bcl-2

8

10

Small-scale

0.963

High

939640

B2CL2
Bcl-2-like protein 2

5

10

Small-scale

0.931

High

939628

BAK
Bcl-2 homologous antagonist/killer

4

10

Small-scale

0.885

High

939615

BAX
Apoptosis regulator BAX

3

10

Small-scale

0.865

High

939627

B2LA1
Bcl-2-related protein A1

2

10

Small-scale

0.768

High

518740

GRAB
Granzyme B

9

2

Small-scale

0.739

High

939604

BID
BH3-interacting domain death agonist

2

0

Small-scale

0.716

High

939624

CASP8
Caspase-8

3

4

Small-scale

0.633

High

840029

CASP3
Caspase-3

2

4

Small-scale

0.625

High

840101

CASP2
Caspase-2

2

4

Small-scale

0.602

High

939668

MTCH2
Mitochondrial carrier homolog 2

2

1

Small-scale

0.571

High

588324

RFA2
Replication protein A 32 kDa subunit

2

0

Small-scale

0.559

High

229991

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.549

High

939613

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

729706

1433B
14-3-3 protein beta/alpha

1

1

Small-scale

0.515

High

920667

NUDT6
Nucleoside diphosphate-linked moiety X motif 6

1

0

High-throughput

0.513

High

939645

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

939646

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

939610

CAV1
Caveolin-1

1

0

Small-scale

0.493

High

408764

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

736910

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.486

High

939612

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.486

High

939621

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.486

High

939663

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.486

High

605984

CAN2
Calpain-2 catalytic subunit

1

0

Small-scale

0.480

High

167858

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

1

Small-scale

0.479

High

172053

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

1

Small-scale

0.479

High

177828

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

1

Small-scale

0.479

High

536840

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.479

High

655129

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

Small-scale

0.479

High

761358

HS71L
Heat shock 70 kDa protein 1-like

1

1

Small-scale

0.479

High

801242

HSPA9
Stress-70 protein, mitochondrial

1

2

Small-scale

0.479

High

939609

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

1

Small-scale

0.479

High

939635

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.479

High

939639

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

1

Small-scale

0.479

High

939643

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

939657

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

1

Small-scale

0.479

High

939666

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

1

Small-scale

0.479

High

939669

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.479

High

126081

AP3B1
AP-3 complex subunit beta-1

1

0

Small-scale

0.458

High

141390

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

219615

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.458

High

286180

CSDE1
Cold shock domain-containing protein E1

1

0

Small-scale

0.458

High

291275

NU155
Nuclear pore complex protein Nup155

1

0

Small-scale

0.458

High

347605

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

417345

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

443285

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.458

High

446808

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

460475

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

Small-scale

0.458

High

464251

FUMH
Fumarate hydratase, mitochondrial

1

0

Small-scale

0.458

High

542754

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

Small-scale

0.458

High

646801

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.458

High

698249

MAP4
Microtubule-associated protein 4

1

0

Small-scale

0.458

High

701785

ABCD3
ATP-binding cassette sub-family D member 3

1

0

Small-scale

0.458

High

787953

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

Small-scale

0.458

High

818725

CAPG
Macrophage-capping protein

1

0

Small-scale

0.458

High

838038

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

852709

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

Small-scale

0.458

High

873192

COPD
Coatomer subunit delta

1

0

Small-scale

0.458

High

934337

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

939605

IF4A1
Eukaryotic initiation factor 4A-I

1

0

Small-scale

0.458

High

939607

RL23A
Large ribosomal subunit protein uL23

1

0

Small-scale

0.458

High

939611

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.458

High

939614

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

939620

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

939622

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.458

High

939623

FLNC
Filamin-C

1

0

Small-scale

0.458

High

939626

PCBP2
Poly(rC)-binding protein 2

1

0

Small-scale

0.458

High

939632

MYH14
Myosin-14

1

0

Small-scale

0.458

High

939633

BRAP
BRCA1-associated protein

1

0

Small-scale

0.458

High

939634

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

Small-scale

0.458

High

939636

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

939637

AHNK2
Protein AHNAK2

1

0

Small-scale

0.458

High

939644

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

939647

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

939648

COR1B
Coronin-1B

1

0

Small-scale

0.458

High

939651

NAT10
RNA cytidine acetyltransferase

1

0

Small-scale

0.458

High

939652

ADT4
ADP/ATP translocase 4

1

0

Small-scale

0.458

High

939653

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

939654

PABP3
Polyadenylate-binding protein 3

1

0

Small-scale

0.458

High

939658

ABCF3
ATP-binding cassette sub-family F member 3

1

0

Small-scale

0.458

High

939660

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

0

Small-scale

0.458

High

939661

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

163265

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

2

Small-scale

0.445

High

582729

EZRI
Ezrin

1

1

Small-scale

0.445

High

622562

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.445

High

634752

GRAH
Granzyme H

1

2

Small-scale

0.445

High

674979

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

Small-scale

0.445

High

683815

MOES
Moesin

1

1

Small-scale

0.445

High

869471

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

1

Small-scale

0.445

High

939619

FADD
FAS-associated death domain protein

1

2

Small-scale

0.445

High

939641

CASPA
Caspase-10

1

4

Small-scale

0.445

High

939618

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

Small-scale

0.437

High

939665

LIMC1
LIM and calponin homology domains-containing protein 1

1

1

Small-scale

0.437

High

853637

MK08
Mitogen-activated protein kinase 8

1

0

Small-scale

0.426

High

912531

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

Small-scale

0.426

High

939606

RHOA
Transforming protein RhoA

1

0

Small-scale

0.426

High

695051

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.346

High

939638

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

2

0

High-throughput

0.328

High

939659

MBD5
Methyl-CpG-binding domain protein 5

2

0

High-throughput

0.328

High

553391

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

2

0

High-throughput

0.318

High

939642

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

939656

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

939625

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.265

Low

939629

RBM48
RNA-binding protein 48

1

0

High-throughput

0.265

Low

939631

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

0

High-throughput

0.265

Low

939649

TBB2B
Tubulin beta-2B chain

1

0

High-throughput

0.265

Low

939650

CRNL1
Crooked neck-like protein 1

1

0

High-throughput

0.265

Low

939664

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.265

Low

939667

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

High-throughput

0.265

Low

123238

PDLI1
PDZ and LIM domain protein 1

1

0

Small-scale

0.249

Low

277618

H2AY
Core histone macro-H2A.1

1

0

Small-scale

0.249

Low

587600

DESP
Desmoplakin

1

0

Small-scale

0.249

Low

615354

SON
Protein SON

1

0

Small-scale

0.249

Low

767815

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

939630

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

939655

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

939662

SEPT9
Septin-9

1

0

Small-scale

0.249

Low

939608

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025