Protein: OTU6B
Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B)

Gene: OTU6B, OTUD6B
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q8N6M0

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0006508 - proteolysis
GO:0008283 - cell population proliferation
GO:0016579 - protein deubiquitination
GO:0017148 - negative regulation of translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508279

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

8

Small-scale

0.687

High

1154872

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.647

High

1329489

OTUB1
Ubiquitin thioesterase OTUB1

2

1

Small-scale

0.641

High

1329496

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

1329493

BTBD1
BTB/POZ domain-containing protein 1

3

3

High-throughput

0.609

High

1147208

ELOB
Elongin-B

1

0

Small-scale

0.606

High

1252465

LN28B
Protein lin-28 homolog B

2

4

Small-scale

0.585

High

822760

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.537

High

620474

NUCL
Nucleolin

1

4

Small-scale

0.515

High

994660

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.515

High

1329487

SERB1
SERPINE1 mRNA-binding protein 1

1

2

Small-scale

0.515

High

859359

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.493

High

1324967

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

4

High-throughput

0.489

High

1329491

BTBD2
BTB/POZ domain-containing protein 2

1

2

High-throughput

0.489

High

346070

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

Small-scale

0.470

High

868554

RL29
Large ribosomal subunit protein eL29

1

1

Small-scale

0.470

High

898728

RL14
Large ribosomal subunit protein eL14

1

1

Small-scale

0.470

High

969309

RS8
Small ribosomal subunit protein eS8

1

1

Small-scale

0.470

High

972908

RS18
Small ribosomal subunit protein uS13

1

1

Small-scale

0.470

High

975805

RL7A
Large ribosomal subunit protein eL8

1

1

Small-scale

0.470

High

982487

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.470

High

985244

RL10A
Large ribosomal subunit protein uL1

1

1

Small-scale

0.470

High

1161942

H31T
Histone H3.1t

1

3

High-throughput

0.470

High

1240450

DHX57
Putative ATP-dependent RNA helicase DHX57

1

4

Small-scale

0.470

High

1278242

DHX29
ATP-dependent RNA helicase DHX29

1

4

Small-scale

0.470

High

445578

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

1329495

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

Small-scale

0.457

High

76345

B4DPD5
Ubiquitin thioesterase

1

1

High-throughput

0.445

High

530082

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.437

High

660675

IF4B
Eukaryotic translation initiation factor 4B

1

3

Small-scale

0.437

High

942746

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

953940

IF4A1
Eukaryotic initiation factor 4A-I

1

4

Small-scale

0.437

High

1047053

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

Small-scale

0.437

High

1093272

FLII
Protein flightless-1 homolog

1

2

Small-scale

0.437

High

1129162

IRF3
Interferon regulatory factor 3

1

3

Small-scale

0.437

High

1130106

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.437

High

1141781

EEA1
Early endosome antigen 1

1

2

High-throughput

0.437

High

1254644

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1258878

H32
Histone H3.2

1

3

High-throughput

0.437

High

1329492

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

1329497

MCTS1
Malignant T-cell-amplified sequence 1

1

1

Small-scale

0.437

High

932409

GALC
Galactocerebrosidase

3

0

High-throughput

0.347

High

1329498

LIMC1
LIM and calponin homology domains-containing protein 1

3

0

High-throughput

0.347

High

516063

ST1A4
Sulfotransferase 1A4

1

0

High-throughput

0.279

Low

665895

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.279

Low

1288201

LYRIC
Protein LYRIC

1

0

High-throughput

0.279

Low

1329494

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.279

Low

183483

CASC3
Protein CASC3

1

0

Small-scale

0.269

Low

428862

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.269

Low

611919

RL35A
Large ribosomal subunit protein eL33

1

0

Small-scale

0.269

Low

612701

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.269

Low

785295

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.269

Low

973504

RS11
Small ribosomal subunit protein uS17

1

0

Small-scale

0.269

Low

985502

RL32
Large ribosomal subunit protein eL32

1

0

Small-scale

0.269

Low

1016106

RL19
Large ribosomal subunit protein eL19

1

0

Small-scale

0.269

Low

1025723

PURA
Transcriptional activator protein Pur-alpha

1

0

Small-scale

0.269

Low

1027591

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.269

Low

1039289

RL6
Large ribosomal subunit protein eL6

1

0

Small-scale

0.269

Low

1057805

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.269

Low

1168533

KNOP1
Lysine-rich nucleolar protein 1

1

0

Small-scale

0.269

Low

1312006

DJC10
DnaJ homolog subfamily C member 10

1

0

Small-scale

0.269

Low

1329488

H1X
Histone H1.10

1

0

Small-scale

0.269

Low

1329490

LTV1
Protein LTV1 homolog

1

0

Small-scale

0.269

Low

1329499

RL36
Large ribosomal subunit protein eL36

1

0

Small-scale

0.269

Low

140999

NOP56
Nucleolar protein 56

1

0

High-throughput

0.249

Low

675081

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

897053

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.249

Low

1138395

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025