Protein: S4A8
Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)

Gene: S4A8, SLC4A8
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q2Y0W8

Gene Ontology (top 5):
GO:0005452 - solute:inorganic anion antiporter activity
GO:0005886 - plasma membrane
GO:0008021 - synaptic vesicle
GO:0008270 - zinc ion binding
GO:0008510 - sodium:bicarbonate symporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1180875

S4A7
Sodium bicarbonate cotransporter 3

3

9

High-throughput

0.855

High

419997

B3A2
Anion exchange protein 2

2

9

High-throughput

0.811

High

190610

MRP4
ATP-binding cassette sub-family C member 4

2

1

High-throughput

0.628

High

243801

ADCY3
Adenylate cyclase type 3

2

3

High-throughput

0.628

High

320455

TM63A
Mechanosensitive cation channel TMEM63A

2

2

High-throughput

0.628

High

1180848

TM63B
Mechanosensitive cation channel TMEM63B

2

2

High-throughput

0.628

High

1180857

ST7L
Suppressor of tumorigenicity 7 protein-like

2

1

High-throughput

0.628

High

1180859

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

2

4

High-throughput

0.628

High

1180869

AT132
Polyamine-transporting ATPase 13A2

2

7

High-throughput

0.628

High

1180852

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.602

High

1180853

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

2

0

High-throughput

0.602

High

1180855

GHDC
GH3 domain-containing protein

2

0

High-throughput

0.602

High

1180862

CA043
Protein C1orf43

2

0

High-throughput

0.602

High

1180867

PCX3
Pecanex-like protein 3

2

0

High-throughput

0.602

High

1180868

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

2

0

High-throughput

0.602

High

1180871

S12A6
Solute carrier family 12 member 6

2

0

High-throughput

0.602

High

1180874

SNX14
Sorting nexin-14

2

0

High-throughput

0.602

High

1180849

S4A10
Sodium-driven chloride bicarbonate exchanger

1

9

High-throughput

0.575

High

1180876

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

9

High-throughput

0.575

High

1085429

SRBP2
Sterol regulatory element-binding protein 2

2

1

High-throughput

0.574

High

1180854

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.546

High

373962

RASN
GTPase NRas

1

12

High-throughput

0.536

High

440582

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.536

High

984139

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

1180847

IPIL2
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2

1

0

High-throughput

0.513

High

1180850

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.513

High

1180864

ULBP2
UL16-binding protein 2

1

0

High-throughput

0.513

High

1180870

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.513

High

162837

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

12

Small-scale

0.501

High

367590

CAH2
Carbonic anhydrase 2

1

5

Small-scale

0.501

High

1180863

REN3B
Regulator of nonsense transcripts 3B

1

1

High-throughput

0.489

High

375566

RASK
GTPase KRas

1

12

High-throughput

0.479

High

1180851

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

321251

ERLN2
Erlin-2

1

10

High-throughput

0.445

High

690263

STOM
Stomatin

1

1

High-throughput

0.445

High

790156

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

2

High-throughput

0.445

High

903939

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.445

High

1119158

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1180872

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

223091

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.426

High

255051

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

620395

NUCL
Nucleolin

1

0

High-throughput

0.426

High

961743

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.426

High

1033004

EWS
RNA-binding protein EWS

1

0

High-throughput

0.426

High

1122612

MLEC
Malectin

1

0

High-throughput

0.426

High

165341

PSA7
Proteasome subunit alpha type-7

1

3

High-throughput

0.407

High

283268

ERLN1
Erlin-1

1

8

High-throughput

0.407

High

485647

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.407

High

521718

H14
Histone H1.4

1

1

High-throughput

0.407

High

596131

H12
Histone H1.2

1

1

High-throughput

0.407

High

944264

TMM33
Transmembrane protein 33

1

4

High-throughput

0.407

High

1126294

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.407

High

1180856

DIK2A
Divergent protein kinase domain 2A

1

2

High-throughput

0.407

High

1180861

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

1

High-throughput

0.407

High

1180865

WDR33
pre-mRNA 3' end processing protein WDR33

1

1

High-throughput

0.407

High

1180866

ARV1
Protein ARV1

1

2

High-throughput

0.407

High

1180860

OMA1
Metalloendopeptidase OMA1, mitochondrial

2

0

High-throughput

0.328

High

1180873

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.328

High

506602

GPHRB
Golgi pH regulator B

1

0

High-throughput

0.279

Low

875983

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.269

Low

429988

JUN
Transcription factor Jun

1

0

High-throughput

0.249

Low

687816

SYVC
Valine--tRNA ligase

1

0

High-throughput

0.232

Low

935405

FGF8
Fibroblast growth factor 8

1

0

High-throughput

0.232

Low

943441

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.232

Low

978550

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

1180858

PIGC
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025