Protein: ZFYV1
Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1)

Gene: ZFYV1, ZFYVE1
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q9HBF4

Gene Ontology (top 5):
GO:0000407 - phagophore assembly site
GO:0005545 - 1-phosphatidylinositol binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005739 - mitochondrion
GO:0005776 - autophagosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186584

TRI18
E3 ubiquitin-protein ligase Midline-1

2

20

High-throughput

0.811

High

1168953

LONF2
LON peptidase N-terminal domain and RING finger protein 2

2

3

High-throughput

0.628

High

1255609

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1335249

KCTD6
BTB/POZ domain-containing protein KCTD6

2

5

High-throughput

0.574

High

1438146

LIMD1
LIM domain-containing protein 1

2

7

High-throughput

0.574

High

279224

ULK1
Serine/threonine-protein kinase ULK1

2

2

Small-scale

0.571

High

967982

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

Small-scale

0.512

High

1060230

B2CL1
Bcl-2-like protein 1

1

2

High-throughput

0.508

High

423210

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

1151657

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.489

High

289028

ERAL1
GTPase Era, mitochondrial

1

2

Small-scale

0.479

High

346361

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

348748

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

Small-scale

0.479

High

507379

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

16

Small-scale

0.479

High

883154

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

1

Small-scale

0.479

High

987220

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

Small-scale

0.479

High

1083529

BST2
Bone marrow stromal antigen 2

1

1

Small-scale

0.479

High

1098482

DNJC3
DnaJ homolog subfamily C member 3

1

4

Small-scale

0.479

High

1104115

RM49
Large ribosomal subunit protein mL49

1

2

Small-scale

0.479

High

1114345

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1201332

OCAD2
OCIA domain-containing protein 2

1

1

Small-scale

0.479

High

1331765

JMY
Junction-mediating and -regulatory protein

1

1

Small-scale

0.479

High

1333815

RDH13
Retinol dehydrogenase 13

1

1

Small-scale

0.479

High

1365510

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1386587

OPTN
Optineurin

1

15

High-throughput

0.479

High

1394132

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

3

Small-scale

0.479

High

1438145

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

3

Small-scale

0.479

High

1438147

RT02
Small ribosomal subunit protein uS2m

1

1

Small-scale

0.479

High

1438148

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

5

Small-scale

0.479

High

1037382

H11
Histone H1.1

1

3

High-throughput

0.470

High

1110095

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.470

High

134387

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

Small-scale

0.458

High

471700

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

Small-scale

0.458

High

641029

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

Small-scale

0.458

High

728826

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.458

High

842243

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

Small-scale

0.458

High

891040

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

Small-scale

0.458

High

903580

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

0

Small-scale

0.458

High

922781

CCHL
Holocytochrome c-type synthase

1

0

Small-scale

0.458

High

1094125

RM28
Large ribosomal subunit protein bL28m

1

0

Small-scale

0.458

High

1286665

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

Small-scale

0.458

High

1385172

ATG2B
Autophagy-related protein 2 homolog B

1

0

Small-scale

0.458

High

1429494

CLPB
Mitochondrial disaggregase

1

0

Small-scale

0.458

High

1438144

RM35
Large ribosomal subunit protein bL35m

1

0

Small-scale

0.458

High

328163

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

19

Small-scale

0.445

High

1295566

MIB1
E3 ubiquitin-protein ligase MIB1

1

5

Small-scale

0.445

High

173393

XPO1
Exportin-1

1

11

High-throughput

0.437

High

276863

VATG1
V-type proton ATPase subunit G 1

1

1

Small-scale

0.437

High

1094631

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

Small-scale

0.437

High

1115075

CUL4A
Cullin-4A

1

12

High-throughput

0.437

High

1241502

EDC4
Enhancer of mRNA-decapping protein 4

1

3

Small-scale

0.437

High

1350654

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

4

Small-scale

0.437

High

1353482

WHAMM
WASP homolog-associated protein with actin, membranes and microtubules

1

1

Small-scale

0.437

High

1408020

H2A1J
Histone H2A type 1-J

1

4

High-throughput

0.437

High

1143540

PCM1
Pericentriolar material 1 protein

1

1

Small-scale

0.407

High

1382634

MGN2
Protein mago nashi homolog 2

2

0

High-throughput

0.316

High

1334229

SPC24
Kinetochore protein Spc24

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025