Protein: PAPD5
Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)

Gene: PAPD5, TENT4B
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q8NDF8

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

977041

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

7

High-throughput

0.811

High

1336630

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

3

High-throughput

0.789

High

1061061

SRSF1
Serine/arginine-rich splicing factor 1

1

6

High-throughput

0.691

High

1099167

SRSF5
Serine/arginine-rich splicing factor 5

1

7

High-throughput

0.691

High

1099441

SRSF6
Serine/arginine-rich splicing factor 6

1

13

High-throughput

0.691

High

1336622

RBM4B
RNA-binding protein 4B

1

7

High-throughput

0.691

High

1336628

RBM4
RNA-binding protein 4

1

6

High-throughput

0.691

High

1336639

RBM28
RNA-binding protein 28

1

4

High-throughput

0.691

High

447233

NPM
Nucleophosmin

3

3

High-throughput

0.667

High

986113

RL8
Large ribosomal subunit protein uL2

3

1

High-throughput

0.667

High

1336613

ZCH14
Zinc finger CCHC domain-containing protein 14

1

1

Small-scale

0.648

High

961778

RL37A
Large ribosomal subunit protein eL43

2

1

High-throughput

0.628

High

984472

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.628

High

1148128

PUM3
Pumilio homolog 3

2

4

High-throughput

0.628

High

1275569

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

3

High-throughput

0.628

High

1336612

DGCR8
Microprocessor complex subunit DGCR8

2

1

High-throughput

0.628

High

1325581

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

15

Small-scale

0.618

High

182330

WDR46
WD repeat-containing protein 46

2

3

High-throughput

0.611

High

979070

RS6
Small ribosomal subunit protein eS6

2

2

High-throughput

0.611

High

1336634

SSF1
Suppressor of SWI4 1 homolog

2

0

High-throughput

0.602

High

1336621

MPH6
M-phase phosphoprotein 6

2

0

High-throughput

0.576

High

1336648

ZN346
Zinc finger protein 346

2

0

High-throughput

0.576

High

1336652

RBMX2
RNA-binding motif protein, X-linked 2

1

4

High-throughput

0.575

High

1336626

ZNF2
Zinc finger protein 2

2

1

High-throughput

0.574

High

396536

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

984856

RL31
Large ribosomal subunit protein eL31

2

3

High-throughput

0.571

High

1336635

EXOS5
Exosome complex component RRP46

2

3

High-throughput

0.571

High

191714

MAGB2
Melanoma-associated antigen B2

2

1

High-throughput

0.549

High

208315

RRP8
Ribosomal RNA-processing protein 8

1

2

High-throughput

0.536

High

287056

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

9

High-throughput

0.536

High

288708

NPM3
Nucleoplasmin-3

1

3

High-throughput

0.536

High

290641

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.536

High

476756

RSSA
Small ribosomal subunit protein uS2

1

4

High-throughput

0.536

High

521816

H14
Histone H1.4

1

6

High-throughput

0.536

High

586789

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.536

High

595826

H13
Histone H1.3

1

6

High-throughput

0.536

High

596243

H12
Histone H1.2

1

6

High-throughput

0.536

High

686284

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

785303

RL4
Large ribosomal subunit protein uL4

1

5

High-throughput

0.536

High

809734

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

824239

RL13A
Large ribosomal subunit protein uL13

1

3

High-throughput

0.536

High

842444

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

859908

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.536

High

898732

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.536

High

909105

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.536

High

975812

RL7A
Large ribosomal subunit protein eL8

1

5

High-throughput

0.536

High

1008804

RED1
Double-stranded RNA-specific editase 1

1

4

High-throughput

0.536

High

1037559

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.536

High

1112096

KRR1
KRR1 small subunit processome component homolog

1

3

High-throughput

0.536

High

1178061

RN151
RING finger protein 151

1

1

High-throughput

0.536

High

1336624

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.536

High

1336625

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.536

High

1336633

EXOS4
Exosome complex component RRP41

1

3

High-throughput

0.536

High

1336647

PURG
Purine-rich element-binding protein gamma

1

1

High-throughput

0.536

High

1336650

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1336654

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.536

High

428868

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.513

High

788714

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

833144

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.513

High

854169

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

985770

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

1127433

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.513

High

1260377

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.513

High

1336616

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1336618

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1336640

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

338908

CBX6
Chromobox protein homolog 6

1

2

High-throughput

0.489

High

1037277

H11
Histone H1.1

1

6

High-throughput

0.489

High

1252628

ZN574
Zinc finger protein 574

1

1

High-throughput

0.489

High

1290010

PNM8A
Paraneoplastic antigen-like protein 8A

1

1

High-throughput

0.489

High

1336617

ZN668
Zinc finger protein 668

1

1

High-throughput

0.489

High

1336619

ZNF48
Zinc finger protein 48

1

1

High-throughput

0.489

High

1336643

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.489

High

66013

U119B
Protein unc-119 homolog B

1

1

High-throughput

0.479

High

96724

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

129262

MEN1
Menin

1

1

High-throughput

0.479

High

141006

NOP56
Nucleolar protein 56

1

4

High-throughput

0.479

High

258566

DIAP2
Protein diaphanous homolog 2

1

2

High-throughput

0.479

High

333497

MPZL1
Myelin protein zero-like protein 1

1

1

High-throughput

0.479

High

346084

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

372607

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

385304

K2C6A
Keratin, type II cytoskeletal 6A

1

3

High-throughput

0.479

High

407321

K2C6B
Keratin, type II cytoskeletal 6B

1

3

High-throughput

0.479

High

487545

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

643937

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

High-throughput

0.479

High

810228

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

903417

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

3

High-throughput

0.479

High

1004850

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1005480

RBM6
RNA-binding protein 6

1

3

High-throughput

0.479

High

1005748

RPP38
Ribonuclease P protein subunit p38

1

1

High-throughput

0.479

High

1032200

EXOSX
Exosome complex component 10

1

5

High-throughput

0.479

High

1098065

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

1105346

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.479

High

1134649

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.479

High

1149446

SKI2
Superkiller complex protein 2

1

8

High-throughput

0.479

High

1191599

RABL6
Rab-like protein 6

1

1

High-throughput

0.479

High

1243572

RSBNL
Lysine-specific demethylase RSBN1L

1

1

High-throughput

0.479

High

1256870

NUD18
8-oxo-dGDP phosphatase NUDT18

1

1

High-throughput

0.479

High

1313098

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

5

High-throughput

0.479

High

1336610

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

2

High-throughput

0.479

High

1336615

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

1336620

SORT
Sortilin

1

1

High-throughput

0.479

High

1336632

EHD1
EH domain-containing protein 1

1

2

High-throughput

0.479

High

1336636

ANLN
Anillin

1

3

High-throughput

0.479

High

1336644

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1336646

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1336649

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.479

High

1336651

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

1

High-throughput

0.479

High

1142802

PEA15
Astrocytic phosphoprotein PEA-15

1

0

Small-scale

0.460

High

191002

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

799989

COIL
Coilin

1

0

High-throughput

0.458

High

886296

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.458

High

1252895

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1332869

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1336611

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1336653

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

72790

B0UZZ8
WD repeat-containing protein 46

1

3

High-throughput

0.445

High

960176

RL26
Large ribosomal subunit protein uL24

1

3

High-throughput

0.445

High

1336609

DDX55
ATP-dependent RNA helicase DDX55

1

5

High-throughput

0.445

High

1336641

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.445

High

504932

H2AB2
Histone H2A-Bbd type 2/3

1

1

High-throughput

0.437

High

589189

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695971

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768670

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1017036

H33
Histone H3.3

1

2

High-throughput

0.437

High

1096758

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.437

High

1104739

NNTM
NAD(P) transhydrogenase, mitochondrial

1

1

High-throughput

0.437

High

1238035

ZSC25
Zinc finger and SCAN domain-containing protein 25

1

2

High-throughput

0.437

High

1238744

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1336614

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

1336623

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

1

High-throughput

0.437

High

1336629

RTF2
Replication termination factor 2

1

1

High-throughput

0.437

High

1336631

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

1

High-throughput

0.437

High

1336637

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.437

High

1336638

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.437

High

601774

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

1119066

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.426

High

1315231

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.407

High

1327320

ZN276
Zinc finger protein 276

1

1

High-throughput

0.407

High

517788

GLI4
Zinc finger protein GLI4

1

0

High-throughput

0.279

Low

1336642

H2AW
Core histone macro-H2A.2

1

0

High-throughput

0.279

Low

1336645

IL17B
Interleukin-17B

1

0

High-throughput

0.279

Low

1336627

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025