Protein: RENT2
Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2)

Gene: RENT2, UPF2
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q9HAU5

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001889 - liver development
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1370117

RENT1
Regulator of nonsense transcripts 1

25

2

Small-scale

0.992

High

1419947

REN3B
Regulator of nonsense transcripts 3B

14

2

Small-scale

0.983

High

1431125

REN3A
Regulator of nonsense transcripts 3A

5

2

Small-scale

0.922

High

1437716

RENT2
Regulator of nonsense transcripts 2

2

1

Small-scale

0.743

High

1145383

RNPS1
RNA-binding protein with serine-rich domain 1

5

2

Small-scale

0.711

High

1400482

SMG1
Serine/threonine-protein kinase SMG1

5

0

Small-scale

0.694

High

807588

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.691

High

1437738

RBM8A
RNA-binding protein 8A

5

0

Small-scale

0.688

High

838788

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.622

High

926416

BLM
RecQ-like DNA helicase BLM

1

1

High-throughput

0.621

High

954003

IF4A1
Eukaryotic initiation factor 4A-I

1

1

Small-scale

0.621

High

242973

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

373186

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.584

High

573678

ENPL
Endoplasmin

2

1

High-throughput

0.584

High

1032248

EXOSX
Exosome complex component 10

2

0

Small-scale

0.575

High

1306922

DCP2
m7GpppN-mRNA hydrolase

2

0

Small-scale

0.575

High

519424

MYB
Transcriptional activator Myb

1

1

High-throughput

0.561

High

1334941

SERB1
SERPINE1 mRNA-binding protein 1

2

0

High-throughput

0.552

High

1437727

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.549

High

1437732

FZR1
Fizzy-related protein homolog

2

0

High-throughput

0.547

High

1047110

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

Small-scale

0.546

High

581590

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

958352

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

1432526

P63
Tumor protein 63

1

1

Small-scale

0.536

High

1436468

AKTIP
AKT-interacting protein

1

0

High-throughput

0.518

High

502136

H2AZ
Histone H2A.Z

1

0

High-throughput

0.513

High

1394800

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.513

High

1437721

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.513

High

1316191

DCP1B
mRNA-decapping enzyme 1B

1

1

High-throughput

0.508

High

1384026

EXOS8
Exosome complex component RRP43

1

1

High-throughput

0.508

High

1428365

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.508

High

1429790

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.508

High

1437735

EXOS1
Exosome complex component CSL4

1

1

High-throughput

0.508

High

178047

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.486

High

688317

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.486

High

859460

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.486

High

982552

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.486

High

983056

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.486

High

1406045

PHB2
Prohibitin-2

1

0

High-throughput

0.486

High

1436994

ZN408
Zinc finger protein 408

1

0

High-throughput

0.486

High

1437731

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.486

High

358804

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.481

High

1008647

MAP1A
Microtubule-associated protein 1A

1

1

High-throughput

0.481

High

1209121

EXOS6
Exosome complex component MTR3

1

2

High-throughput

0.481

High

1368387

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.481

High

1437722

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.481

High

1437730

CIZ1
Cip1-interacting zinc finger protein

1

1

High-throughput

0.481

High

128476

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.480

High

173390

XPO1
Exportin-1

1

2

High-throughput

0.479

High

256991

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

346358

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

401509

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

406662

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

473097

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

681724

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.479

High

905159

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

981109

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1045784

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1100401

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1251442

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

1255602

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1316460

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.479

High

1338276

KMT2C
Histone-lysine N-methyltransferase 2C

1

1

High-throughput

0.479

High

1437717

EXOS4
Exosome complex component RRP41

1

2

Small-scale

0.479

High

1437718

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

269382

HSF2B
Heat shock factor 2-binding protein

1

0

High-throughput

0.460

High

352556

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.460

High

405545

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.460

High

416767

TYSY
Thymidylate synthase

1

0

High-throughput

0.460

High

431904

ITB1
Integrin beta-1

1

0

High-throughput

0.460

High

437009

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.460

High

446051

ENOA
Alpha-enolase

1

0

High-throughput

0.460

High

517709

ZBT48
Zinc finger and BTB domain-containing protein 48

1

0

High-throughput

0.460

High

570987

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.460

High

585002

ZNF44
Zinc finger protein 44

1

0

High-throughput

0.460

High

601865

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.460

High

686443

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.460

High

698030

CALR
Calreticulin

1

0

High-throughput

0.460

High

877786

TNNI2
Troponin I, fast skeletal muscle

1

0

High-throughput

0.460

High

939231

SUMO3
Small ubiquitin-related modifier 3

1

0

High-throughput

0.460

High

967561

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.460

High

979255

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.460

High

986224

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.460

High

1005646

PITX1
Pituitary homeobox 1

1

0

High-throughput

0.460

High

1016378

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.460

High

1118603

TBB2A
Tubulin beta-2A chain

1

0

High-throughput

0.460

High

1226651

E4F1
Transcription factor E4F1

1

0

High-throughput

0.460

High

1259028

CENPU
Centromere protein U

1

0

High-throughput

0.460

High

1272120

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.460

High

1327465

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.460

High

1388415

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.460

High

1433309

WNK1
Serine/threonine-protein kinase WNK1

1

0

High-throughput

0.460

High

1437719

RM40
Large ribosomal subunit protein mL40

1

0

High-throughput

0.460

High

1437734

RRP7A
Ribosomal RNA-processing protein 7 homolog A

1

0

High-throughput

0.460

High

129446

MEN1
Menin

1

0

High-throughput

0.458

High

320063

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

337395

PARN
Poly(A)-specific ribonuclease PARN

1

0

Small-scale

0.458

High

396977

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

516782

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

589732

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696552

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

703067

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.458

High

831455

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

890223

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.458

High

899676

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

0

High-throughput

0.458

High

900169

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.458

High

939440

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.458

High

972573

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

1024854

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1118338

EXOS2
Exosome complex component RRP4

1

0

Small-scale

0.458

High

1276811

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1403790

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1431543

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1433932

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1437720

ANLN
Anillin

1

0

High-throughput

0.458

High

1437726

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1437728

INT6
Integrator complex subunit 6

1

0

Small-scale

0.458

High

430376

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

765903

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

1314701

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

Small-scale

0.445

High

1340202

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

2

High-throughput

0.445

High

1404414

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.445

High

1437736

RBM7
RNA-binding protein 7

1

1

High-throughput

0.445

High

1437725

ABCF2
ATP-binding cassette sub-family F member 2

1

1

High-throughput

0.439

High

412633

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

142420

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

191813

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.426

High

340678

STABP
STAM-binding protein

1

0

High-throughput

0.426

High

344327

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

584148

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.426

High

915032

AK1C2
Aldo-keto reductase family 1 member C2

1

0

High-throughput

0.426

High

1111278

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1437723

VSX1
Visual system homeobox 1

1

0

High-throughput

0.426

High

1437724

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.426

High

1437737

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

High-throughput

0.426

High

330326

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

1356542

RAB2B
Ras-related protein Rab-2B

1

0

High-throughput

0.279

Low

328590

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.251

Low

380718

HBAZ
Hemoglobin subunit zeta

1

0

High-throughput

0.251

Low

562815

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.251

Low

931452

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.251

Low

1143680

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.251

Low

1291686

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.251

Low

1347085

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.251

Low

1372163

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.251

Low

1408234

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.251

Low

1437739

HS3SA
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

1

0

High-throughput

0.251

Low

769219

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879478

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1416684

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1437729

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1437733

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low

1335728

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025