Protein: TGM3
Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]

Gene: TGM3
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q08188

Gene Ontology (top 5):
GO:0003810 - protein-glutamine gamma-glutamyltransferase activity
GO:0003824 - catalytic activity
GO:0005198 - structural molecule activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391608

FRIH
Ferritin heavy chain

2

2

High-throughput

0.628

High

1062307

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

1062283

MITOK
Mitochondrial potassium channel

3

2

High-throughput

0.609

High

413704

P53
Cellular tumor antigen p53

2

2

Small-scale

0.584

High

282706

E2F6
Transcription factor E2F6

2

1

High-throughput

0.574

High

1062303

TB22B
TBC1 domain family member 22B

2

2

High-throughput

0.574

High

521325

ARAF
Serine/threonine-protein kinase A-Raf

2

3

High-throughput

0.571

High

1062265

DOCK8
Dedicator of cytokinesis protein 8

2

2

High-throughput

0.571

High

943839

CF298
Cilia- and flagella-associated protein 298

2

1

High-throughput

0.558

High

1062271

ARH40
Rho guanine nucleotide exchange factor 40

2

0

High-throughput

0.547

High

292621

RENR
Renin receptor

1

2

High-throughput

0.536

High

301801

ANXA9
Annexin A9

1

2

High-throughput

0.536

High

563678

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

602781

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

722781

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

2

High-throughput

0.536

High

733340

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

861584

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.536

High

1062238

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

1062251

APTX
Aprataxin

1

1

High-throughput

0.536

High

1062259

DAA19
Dynein axonemal assembly factor 19

1

1

High-throughput

0.536

High

1062263

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.536

High

1062267

MYBPP
MYCBP-associated protein

1

1

High-throughput

0.536

High

1062284

MTNB
Methylthioribulose-1-phosphate dehydratase

1

1

High-throughput

0.536

High

1062286

CDK15
Cyclin-dependent kinase 15

1

1

High-throughput

0.536

High

1062293

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

1062301

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1062321

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

1062322

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.536

High

1062261

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.521

High

866653

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

1062325

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.501

High

1062237

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.493

High

185184

FANCG
Fanconi anemia group G protein

1

1

High-throughput

0.489

High

358058

ADH1G
Alcohol dehydrogenase 1C

1

1

High-throughput

0.489

High

420250

IFNA4
Interferon alpha-4

1

1

High-throughput

0.489

High

666826

CCNC
Cyclin-C

1

1

High-throughput

0.489

High

755476

ERD22
ER lumen protein-retaining receptor 2

1

1

High-throughput

0.489

High

876320

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.489

High

896688

ASCL1
Achaete-scute homolog 1

1

1

High-throughput

0.489

High

943041

STX17
Syntaxin-17

1

2

High-throughput

0.489

High

1023762

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.489

High

1062239

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

1062249

AMTN
Amelotin

1

1

High-throughput

0.489

High

1062254

MOGT3
2-acylglycerol O-acyltransferase 3

1

1

High-throughput

0.489

High

1062256

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.489

High

1062257

AROS
Active regulator of SIRT1

1

1

High-throughput

0.489

High

1062264

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.489

High

1062268

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.489

High

1062269

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.489

High

1062275

THAP4
Peroxynitrite isomerase THAP4

1

4

High-throughput

0.489

High

1062280

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.489

High

1062282

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

1062289

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

1062291

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

1062297

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

1

High-throughput

0.489

High

1062299

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.489

High

1062308

THA10
THAP domain-containing protein 10

1

1

High-throughput

0.489

High

1062314

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

131987

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

1062312

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

141442

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

241497

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

323342

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

371859

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

411805

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

456704

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

537040

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

587634

DESP
Desmoplakin

1

1

High-throughput

0.479

High

635584

FILA
Filaggrin

1

3

High-throughput

0.479

High

729543

CASPE
Caspase-14

1

2

High-throughput

0.479

High

830620

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

888006

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

1036710

DSG1
Desmoglein-1

1

2

High-throughput

0.479

High

1062224

DSC1
Desmocollin-1

1

1

High-throughput

0.479

High

1062227

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

2

High-throughput

0.479

High

1062228

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1062230

PKP1
Plakophilin-1

1

1

High-throughput

0.479

High

1062231

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.479

High

1062236

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1062242

FILA2
Filaggrin-2

1

5

High-throughput

0.479

High

1062258

PRAG1
Inactive tyrosine-protein kinase PRAG1

1

1

High-throughput

0.479

High

1062276

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1062278

RBP56
TATA-binding protein-associated factor 2N

1

6

High-throughput

0.479

High

1062279

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

1062288

RANB9
Ran-binding protein 9

1

2

Small-scale

0.479

High

1062292

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

1062305

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1062311

DUX4
Double homeobox protein 4

1

1

High-throughput

0.479

High

1062318

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

1062323

LOXL2
Lysyl oxidase homolog 2

1

4

High-throughput

0.479

High

481257

HMGB1
High mobility group protein B1

1

3

Small-scale

0.464

High

141926

PODXL
Podocalyxin

1

0

Small-scale

0.458

High

275172

GGCT
Gamma-glutamylcyclotransferase

1

0

High-throughput

0.458

High

293612

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

317632

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.458

High

324817

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

423641

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

623301

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

767180

MERL
Merlin

1

0

High-throughput

0.458

High

1062229

CUL4A
Cullin-4A

1

0

High-throughput

0.458

High

1062232

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

1062244

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

1062246

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1062274

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

1062285

SPB12
Serpin B12

1

0

High-throughput

0.458

High

1062302

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1062310

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.458

High

1062313

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

1062320

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

0

Small-scale

0.458

High

911560

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

952129

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

1056684

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.445

High

1062223

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.445

High

1062225

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1062241

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.445

High

1062243

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

302497

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.437

High

755889

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.437

High

970396

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1062234

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

1

3

High-throughput

0.437

High

1062235

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.437

High

1062248

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.437

High

1062252

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.437

High

1062270

TP4AP
Short transient receptor potential channel 4-associated protein

1

1

High-throughput

0.437

High

1062281

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

Small-scale

0.437

High

1062294

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

1062296

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.437

High

1062298

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

1062300

ANLN
Anillin

1

1

High-throughput

0.437

High

1062304

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

1062319

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

3

Small-scale

0.437

High

213118

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

1062260

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

1062226

IFT88
Intraflagellar transport protein 88 homolog

1

2

High-throughput

0.407

High

1062247

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

1062295

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.407

High

1062290

PHAF1
Phagosome assembly factor 1

3

0

High-throughput

0.347

High

1062315

FBXL4
F-box/LRR-repeat protein 4

2

0

High-throughput

0.328

High

1062324

PPME1
Protein phosphatase methylesterase 1

2

0

High-throughput

0.319

High

938648

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

High-throughput

0.279

Low

983647

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.279

Low

1034920

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.279

Low

1062233

I5P1
Inositol polyphosphate-5-phosphatase A

1

0

High-throughput

0.279

Low

1062240

VWA3B
von Willebrand factor A domain-containing protein 3B

1

0

High-throughput

0.279

Low

1062250

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

1062255

BPHL
Serine hydrolase BPHL

1

0

High-throughput

0.279

Low

1062262

ORML3
ORM1-like protein 3

1

0

High-throughput

0.279

Low

1062266

TYMOS
TYMS opposite strand protein

1

0

High-throughput

0.279

Low

1062272

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.279

Low

1062273

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

1062306

ZN224
Zinc finger protein 224

1

0

High-throughput

0.279

Low

1062309

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1062316

COR1C
Coronin-1C

1

0

High-throughput

0.279

Low

1062317

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.279

Low

892671

DNLI4
DNA ligase 4

1

0

High-throughput

0.249

Low

1062245

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

1062253

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

1062277

RND1
Rho-related GTP-binding protein Rho6

1

0

High-throughput

0.249

Low

1062287

GSDMA
Gasdermin-A

1

0

High-throughput

0.249

Low

1062326

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.249

Low

841168

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025