Protein: INVO
Involucrin

Gene: INVO, IVL
Organism: Homo sapiens
Interactions: 138
UniProt ID: P07476

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0010224 - response to UV-B

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457911

RBM24
RNA-binding protein 24

3

8

High-throughput

0.667

High

391541

FRIH
Ferritin heavy chain

2

1

High-throughput

0.628

High

457904

CDK15
Cyclin-dependent kinase 15

2

5

High-throughput

0.628

High

457872

MYOME
Myomegalin

2

7

High-throughput

0.611

High

457934

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

457832

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

1

High-throughput

0.609

High

457865

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

1

High-throughput

0.609

High

457901

GMCL1
Germ cell-less protein-like 1

3

3

High-throughput

0.609

High

457919

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

3

1

High-throughput

0.609

High

376967

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

457867

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.602

High

457899

RNF25
E3 ubiquitin-protein ligase RNF25

2

0

High-throughput

0.602

High

457842

MPI
Mannose-6-phosphate isomerase

2

0

High-throughput

0.585

High

457885

FRMD1
FERM domain-containing protein 1

2

8

High-throughput

0.574

High

457918

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

1

High-throughput

0.574

High

457921

SHCAF
SIN3-HDAC complex-associated factor

2

1

High-throughput

0.574

High

457924

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

457898

ACD
Adrenocortical dysplasia protein homolog

1

1

High-throughput

0.573

High

457862

ITA9
Integrin alpha-9

2

3

High-throughput

0.558

High

132554

UPK1A
Uroplakin-1a

1

5

High-throughput

0.536

High

222346

TSN6
Tetraspanin-6

1

4

High-throughput

0.536

High

457841

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

457853

SSBP2
Single-stranded DNA-binding protein 2

1

2

High-throughput

0.536

High

457857

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.536

High

457859

FSTL1
Follistatin-related protein 1

1

2

High-throughput

0.536

High

457860

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

2

High-throughput

0.536

High

457866

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

457874

JADE1
Protein Jade-1

1

2

High-throughput

0.536

High

457879

CERS3
Ceramide synthase 3

1

1

High-throughput

0.536

High

457903

FMNL2
Formin-like protein 2

1

2

High-throughput

0.536

High

457913

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

457922

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

457926

KLH11
Kelch-like protein 11

1

4

High-throughput

0.536

High

457927

GID8
Glucose-induced degradation protein 8 homolog

1

1

High-throughput

0.536

High

457932

HDAC9
Histone deacetylase 9

1

8

High-throughput

0.536

High

457938

CHMP3
Charged multivesicular body protein 3

1

3

High-throughput

0.536

High

457940

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.536

High

194454

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

292522

RENR
Renin receptor

1

0

High-throughput

0.513

High

352667

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

457833

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

457847

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

457850

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

457854

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

457855

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.513

High

457856

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.513

High

457895

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

457897

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

457907

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.513

High

457909

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.513

High

457912

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

457914

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

457936

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

457925

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.504

High

407360

K2C1
Keratin, type II cytoskeletal 1

1

3

Small-scale

0.501

High

457826

INVO
Involucrin

1

11

Small-scale

0.501

High

457831

DESP
Desmoplakin

1

8

Small-scale

0.501

High

457845

CRK
Adapter molecule crk

1

13

High-throughput

0.501

High

457941

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

457861

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.493

High

254745

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.489

High

325266

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

331622

MBD4
Methyl-CpG-binding domain protein 4

1

3

High-throughput

0.489

High

342488

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

457834

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

2

High-throughput

0.489

High

457836

PO3F3
POU domain, class 3, transcription factor 3

1

6

High-throughput

0.489

High

457858

GABPA
GA-binding protein alpha chain

1

10

High-throughput

0.489

High

457870

FNDC1
Fibronectin type III domain-containing protein 1

1

7

High-throughput

0.489

High

457871

LRC10
Leucine-rich repeat-containing protein 10

1

2

High-throughput

0.489

High

457875

DPPA4
Developmental pluripotency-associated protein 4

1

4

High-throughput

0.489

High

457876

ZN550
Zinc finger protein 550

1

2

High-throughput

0.489

High

457881

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.489

High

457883

AN36B
Ankyrin repeat domain-containing protein 36B

1

10

High-throughput

0.489

High

457887

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.489

High

457889

O13C3
Olfactory receptor 13C3

1

1

High-throughput

0.489

High

457890

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.489

High

457894

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

457906

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

457908

SH23A
SH2 domain-containing protein 3A

1

20

High-throughput

0.489

High

457916

ZDHC6
Palmitoyltransferase ZDHHC6

1

2

High-throughput

0.489

High

457931

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

457933

COR1C
Coronin-1C

1

13

High-throughput

0.489

High

457935

PHF8
Histone lysine demethylase PHF8

1

1

High-throughput

0.489

High

370260

CYTA
Cystatin-A

1

0

Small-scale

0.480

High

457837

LORI
Loricrin

1

0

Small-scale

0.480

High

165240

PSA7
Proteasome subunit alpha type-7

1

1

High-throughput

0.479

High

456174

CATD
Cathepsin D

1

1

High-throughput

0.479

High

457827

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

457828

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

457830

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

457835

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.479

High

457838

SPB3
Serpin B3

1

1

High-throughput

0.479

High

457839

CASPE
Caspase-14

1

1

High-throughput

0.479

High

457840

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

457843

SPB5
Serpin B5

1

1

High-throughput

0.479

High

457846

LEG7
Galectin-7

1

1

High-throughput

0.479

High

457852

ACTA
Actin, aortic smooth muscle

1

10

High-throughput

0.479

High

457863

PKP1
Plakophilin-1

1

7

High-throughput

0.479

High

457888

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

457915

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

457917

RANB3
Ran-binding protein 3

1

1

High-throughput

0.479

High

457929

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.479

High

331949

KAT7
Histone acetyltransferase KAT7

1

0

High-throughput

0.458

High

457864

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.458

High

457928

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

457844

PI4KA
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.445

High

457873

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.445

High

457869

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.437

High

457892

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.437

High

457939

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.437

High

96890

E9PDS3
Integrin subunit alpha 9

1

3

High-throughput

0.407

High

457849

GPC3
Glypican-3

1

1

High-throughput

0.407

High

457886

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

457902

SUSD3
Sushi domain-containing protein 3

3

0

High-throughput

0.347

High

457920

UD110
UDP-glucuronosyltransferase 1A10

3

0

High-throughput

0.347

High

457884

CCYL1
Cyclin-Y-like protein 1

2

0

High-throughput

0.328

High

457937

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

213387

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

0

High-throughput

0.288

High

226926

LIAS
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.279

Low

229205

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.279

Low

327148

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.279

Low

457829

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.279

Low

457848

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

457851

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

457868

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

457877

BPHL
Serine hydrolase BPHL

1

0

High-throughput

0.279

Low

457878

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.279

Low

457882

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

457891

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

457896

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

457900

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

457905

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

457910

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

457923

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

457930

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

457893

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low

457880

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025