Protein: LX12B
Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)

Gene: LX12B, ALOX12B
Organism: Homo sapiens
Interactions: 113
UniProt ID: O75342

Gene Ontology (top 5):
GO:0004052 - arachidonate 12(S)-lipoxygenase activity
GO:0005506 - iron ion binding
GO:0005829 - cytosol
GO:0006497 - protein lipidation
GO:0006665 - sphingolipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

276555

ANF
Natriuretic peptides A

2

1

High-throughput

0.628

High

276626

LOXE3
Hydroperoxide isomerase ALOXE3

1

3

Small-scale

0.618

High

276596

DPPA4
Developmental pluripotency-associated protein 4

3

1

High-throughput

0.609

High

276618

GMCL1
Germ cell-less protein-like 1

3

2

High-throughput

0.609

High

276556

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

276629

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

2

0

High-throughput

0.602

High

231076

AIRE
Autoimmune regulator

2

1

High-throughput

0.574

High

276549

TOX4
TOX high mobility group box family member 4

2

1

High-throughput

0.574

High

276588

ZIC1
Zinc finger protein ZIC 1

2

2

High-throughput

0.574

High

276589

CCD27
Coiled-coil domain-containing protein 27

2

2

High-throughput

0.574

High

276637

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

276546

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

2

1

High-throughput

0.558

High

276561

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

276562

VAV
Proto-oncogene vav

1

1

High-throughput

0.536

High

276572

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.536

High

276582

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.536

High

276602

AROS
Active regulator of SIRT1

1

1

High-throughput

0.536

High

276610

THAP4
Peroxynitrite isomerase THAP4

1

1

High-throughput

0.536

High

276611

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

1

High-throughput

0.536

High

276614

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.536

High

276635

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

276646

RN115
E3 ubiquitin-protein ligase RNF115

1

3

High-throughput

0.536

High

229194

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.513

High

276547

RENR
Renin receptor

1

0

High-throughput

0.513

High

276550

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.513

High

276552

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

276553

ADH1G
Alcohol dehydrogenase 1C

1

0

High-throughput

0.513

High

276560

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.513

High

276563

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

276567

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

276573

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

276575

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

276577

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

276579

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

276604

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1

0

High-throughput

0.513

High

276606

D106A
Beta-defensin 106

1

0

High-throughput

0.513

High

276607

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.513

High

276613

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

276617

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.513

High

276621

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.513

High

276625

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

276636

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.513

High

213383

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

1

High-throughput

0.504

High

276557

IFNA4
Interferon alpha-4

1

1

High-throughput

0.489

High

276568

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.489

High

276584

ZN154
Zinc finger protein 154

1

1

High-throughput

0.489

High

276601

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

276603

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

1

High-throughput

0.489

High

276608

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.489

High

276615

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

276623

SH23A
SH2 domain-containing protein 3A

1

9

High-throughput

0.489

High

276631

HES4
Transcription factor HES-4

1

1

High-throughput

0.489

High

276632

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

1

High-throughput

0.489

High

276640

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

1

High-throughput

0.489

High

276642

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

222574

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

276554

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

276587

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

276612

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

276570

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

276627

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

276633

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

276565

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

276593

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

276594

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

276622

PKP2
Plakophilin-2

1

1

High-throughput

0.445

High

276643

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.445

High

276628

RNF38
E3 ubiquitin-protein ligase RNF38

1

5

Small-scale

0.437

High

219575

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.426

High

261017

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

276569

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.426

High

276581

COAA1

1

2

High-throughput

0.407

High

276551

GPAN1
G patch domain and ankyrin repeat-containing protein 1

3

0

High-throughput

0.347

High

276586

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

0

High-throughput

0.347

High

276616

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

276605

DAA19
Dynein axonemal assembly factor 19

2

0

High-throughput

0.328

High

135760

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

222337

TSN6
Tetraspanin-6

1

0

High-throughput

0.279

Low

276545

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

276559

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

276564

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.279

Low

276566

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

276571

ASCL1
Achaete-scute homolog 1

1

0

High-throughput

0.279

Low

276574

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

276576

ANTR2
Anthrax toxin receptor 2

1

0

High-throughput

0.279

Low

276583

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.279

Low

276585

MMRN1
Multimerin-1

1

0

High-throughput

0.279

Low

276590

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

276591

DNAL1
Dynein axonemal light chain 1

1

0

High-throughput

0.279

Low

276592

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

276597

APTX
Aprataxin

1

0

High-throughput

0.279

Low

276598

ZN550
Zinc finger protein 550

1

0

High-throughput

0.279

Low

276599

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.279

Low

276600

BPHL
Serine hydrolase BPHL

1

0

High-throughput

0.279

Low

276609

CRGN
Gamma-crystallin N

1

0

High-throughput

0.279

Low

276619

CABS1
Calcium-binding and spermatid-specific protein 1

1

0

High-throughput

0.279

Low

276624

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

276630

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

276634

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

276639

THA10
THAP domain-containing protein 10

1

0

High-throughput

0.279

Low

276644

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

276645

FCF1
rRNA-processing protein FCF1 homolog

1

0

High-throughput

0.279

Low

72907

FHAD1
Forkhead-associated domain-containing protein 1

1

0

High-throughput

0.249

Low

104948

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

276548

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

276558

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

276578

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.249

Low

276580

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

276638

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

238766

SSX4
Protein SSX4

1

0

High-throughput

0.232

Low

276595

KLH10
Kelch-like protein 10

1

0

High-throughput

0.232

Low

276620

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

276641

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025