Protein: ZN281
Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99)

Gene: ZN281, ZNF281
Organism: Homo sapiens
Interactions: 171
UniProt ID: Q9Y2X9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

836107

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.724

High

587077

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.691

High

1085555

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.691

High

1242904

HIPK4
Homeodomain-interacting protein kinase 4

1

5

High-throughput

0.691

High

1331906

ZN644
Zinc finger protein 644

1

15

High-throughput

0.691

High

1377473

LMBL1
Lethal(3)malignant brain tumor-like protein 1

3

1

High-throughput

0.675

High

348299

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.672

High

818635

SOX2
Transcription factor SOX-2

3

17

Small-scale

0.640

High

239001

LPXN
Leupaxin

2

20

High-throughput

0.628

High

1023030

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.628

High

1356375

FBW1B
F-box/WD repeat-containing protein 11

2

1

Small-scale

0.624

High

984044

ZBT16
Zinc finger and BTB domain-containing protein 16

1

15

High-throughput

0.621

High

149449

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.618

High

204238

KLF4
Krueppel-like factor 4

1

18

High-throughput

0.618

High

317041

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.618

High

505317

EGR2
E3 SUMO-protein ligase EGR2

1

17

High-throughput

0.618

High

826380

CDK8
Cyclin-dependent kinase 8

1

4

High-throughput

0.618

High

841360

CDK7
Cyclin-dependent kinase 7

1

2

High-throughput

0.618

High

855963

ZN131
Zinc finger protein 131

1

19

High-throughput

0.618

High

884271

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.618

High

974708

MECOM
Histone-lysine N-methyltransferase MECOM

1

16

High-throughput

0.618

High

1046775

KLF5
Krueppel-like factor 5

1

18

High-throughput

0.618

High

1239182

ZBT38
Zinc finger and BTB domain-containing protein 38

1

16

Small-scale

0.618

High

1254968

SP7
Transcription factor Sp7

1

17

High-throughput

0.618

High

1315411

KLF16
Krueppel-like factor 16

1

19

High-throughput

0.618

High

1355801

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.618

High

1377474

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

603802

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

3

High-throughput

0.611

High

1173370

RFPLB
Ret finger protein-like 4B

2

8

High-throughput

0.611

High

776861

STAT3
Signal transducer and activator of transcription 3

2

1

High-throughput

0.594

High

1166191

OLFM4
Olfactomedin-4

2

0

High-throughput

0.585

High

360562

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

11

High-throughput

0.584

High

935408

H31
Histone H3.1

2

13

High-throughput

0.584

High

1222651

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.584

High

1334450

NANOG
Homeobox protein NANOG

2

12

Small-scale

0.584

High

1044297

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.575

High

1132275

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

370768

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1330897

Q9H4D1
Protein kinase

1

2

High-throughput

0.553

High

1267458

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

3

High-throughput

0.542

High

1326664

EGLN1
Egl nine homolog 1

1

1

High-throughput

0.541

High

1031307

SKP2
S-phase kinase-associated protein 2

1

1

High-throughput

0.536

High

1167348

BCOR
BCL-6 corepressor

1

5

Small-scale

0.536

High

1239426

MLKL
Mixed lineage kinase domain-like protein

1

2

High-throughput

0.536

High

1330571

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.536

High

1357494

MAGD2
Melanoma-associated antigen D2

1

3

High-throughput

0.536

High

1377475

NGN3
Neurogenin-3

1

3

High-throughput

0.536

High

792114

HD
Huntingtin

1

4

High-throughput

0.515

High

1287440

OPTN
Optineurin

1

4

High-throughput

0.515

High

883683

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.514

High

976823

TAP2
Antigen peptide transporter 2

1

0

High-throughput

0.513

High

1222044

MILK2
MICAL-like protein 2

1

0

High-throughput

0.513

High

1270102

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.513

High

1355746

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

253282

KI21B
Kinesin-like protein KIF21B

1

2

High-throughput

0.489

High

825112

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.489

High

1030921

KCAB2
Voltage-gated potassium channel subunit beta-2

1

1

High-throughput

0.489

High

1056265

I13R2
Interleukin-13 receptor subunit alpha-2

1

1

High-throughput

0.489

High

1101801

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

1168376

THSD4
Thrombospondin type-1 domain-containing protein 4

1

1

High-throughput

0.489

High

1187568

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

7

High-throughput

0.489

High

1238131

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

1252340

GOGA5
Golgin subfamily A member 5

1

4

High-throughput

0.489

High

1327206

DRC3
Dynein regulatory complex subunit 3

1

2

High-throughput

0.489

High

1377451

TDRKH
Tudor and KH domain-containing protein

1

2

High-throughput

0.489

High

135178

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

164512

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

171098

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

179895

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

183178

KDM6A
Lysine-specific demethylase 6A

1

3

Small-scale

0.479

High

211998

TLX3
T-cell leukemia homeobox protein 3

1

11

High-throughput

0.479

High

213407

TLX2
T-cell leukemia homeobox protein 2

1

8

High-throughput

0.479

High

782701

HNF4A
Hepatocyte nuclear factor 4-alpha

1

13

High-throughput

0.479

High

785428

ELK3
ETS domain-containing protein Elk-3

1

12

High-throughput

0.479

High

225808

SOX15
Transcription factor SOX-15

1

13

High-throughput

0.479

High

245119

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

302057

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

High-throughput

0.479

High

309180

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

319390

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

377822

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

398148

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

443273

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

456019

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

486850

MYB
Transcriptional activator Myb

1

1

High-throughput

0.479

High

487863

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

507531

ERG
Transcriptional regulator ERG

1

10

High-throughput

0.479

High

546059

MYOD1
Myoblast determination protein 1

1

1

High-throughput

0.479

High

570206

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

617395

SP100
Nuclear autoantigen Sp-100

1

11

High-throughput

0.479

High

620227

PAX7
Paired box protein Pax-7

1

4

High-throughput

0.479

High

620446

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

620598

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

High-throughput

0.479

High

641610

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

653040

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

658580

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

669091

PML
Protein PML

1

20

High-throughput

0.479

High

679196

TLX1
T-cell leukemia homeobox protein 1

1

9

High-throughput

0.479

High

727618

HNF1B
Hepatocyte nuclear factor 1-beta

1

6

High-throughput

0.479

High

727945

SOX6
Transcription factor SOX-6

1

16

High-throughput

0.479

High

750550

COIL
Coilin

1

3

High-throughput

0.479

High

799047

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.479

High

802523

ATRX
Transcriptional regulator ATRX

1

3

Small-scale

0.479

High

818851

SOX9
Transcription factor SOX-9

1

16

High-throughput

0.479

High

831828

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.479

High

869789

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

881835

SOX10
Transcription factor SOX-10

1

16

High-throughput

0.479

High

918174

H4
Histone H4

1

4

High-throughput

0.479

High

918783

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

941605

RNF4
E3 ubiquitin-protein ligase RNF4

1

17

High-throughput

0.479

High

952714

H33
Histone H3.3

1

13

High-throughput

0.479

High

968016

PO5F1
POU domain, class 5, transcription factor 1

1

5

Small-scale

0.479

High

980917

TLE3
Transducin-like enhancer protein 3

1

3

High-throughput

0.479

High

1018283

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

1027341

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1060392

NFIX
Nuclear factor 1 X-type

1

7

High-throughput

0.479

High

1063700

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1067208

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

1075036

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

1077622

ELF2
ETS-related transcription factor Elf-2

1

10

High-throughput

0.479

High

1080506

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

1189079

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1190889

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.479

High

1200776

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1221861

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1244581

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

1262847

PHIP
PH-interacting protein

1

2

High-throughput

0.479

High

1269989

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1288401

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1300627

PHF12
PHD finger protein 12

1

10

High-throughput

0.479

High

1304728

FEV
Protein FEV

1

10

High-throughput

0.479

High

1332333

SOX17
Transcription factor SOX-17

1

16

High-throughput

0.479

High

1332801

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1335252

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1348399

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1354937

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1356645

ELF5
ETS-related transcription factor Elf-5

1

11

High-throughput

0.479

High

1377472

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1067861

PDIA6
Protein disulfide-isomerase A6

1

8

High-throughput

0.470

High

524098

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

554110

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652667

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

721838

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

1021387

FOXL1
Forkhead box protein L1

1

0

High-throughput

0.458

High

1072077

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1161853

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1260564

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1303029

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1327161

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1377132

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

529941

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

1037449

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.445

High

1175266

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.445

High

1232595

STAG2
Cohesin subunit SA-2

1

1

Small-scale

0.445

High

1261594

STAG1
Cohesin subunit SA-1

1

1

Small-scale

0.445

High

1349138

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

323341

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

17

High-throughput

0.437

High

882651

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

1174017

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

2

Small-scale

0.437

High

1331685

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1331816

RNF41
E3 ubiquitin-protein ligase NRDP1

1

12

Small-scale

0.437

High

48754

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

275482

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.407

High

596602

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.282

High

813863

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1254691

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1308569

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

1328384

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.279

Low

1332434

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.279

Low

47329

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1166092

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1239351

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024