Protein: PARN
Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)

Gene: PARN
Organism: Homo sapiens
Interactions: 124
UniProt ID: O95453

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000495 - box H/ACA sno(s)RNA 3'-end processing
GO:0003723 - RNA binding
GO:0003730 - mRNA 3'-UTR binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

314638

BYST
Bystin

4

0

High-throughput

0.670

High

314629

H11
Histone H1.1

3

5

High-throughput

0.667

High

314642

TEAD4
Transcriptional enhancer factor TEF-3

3

0

High-throughput

0.638

High

314595

ESR1
Estrogen receptor

3

2

High-throughput

0.633

High

314687

SLX9
Ribosome biogenesis protein SLX9 homolog

3

0

Small-scale

0.628

High

314592

PARN
Poly(A)-specific ribonuclease PARN

1

1

Small-scale

0.618

High

262346

TULP3
Tubby-related protein 3

2

0

High-throughput

0.602

High

314646

TSR1
Pre-rRNA-processing protein TSR1 homolog

2

0

High-throughput

0.602

High

314676

BARD1
BRCA1-associated RING domain protein 1

1

1

Small-scale

0.597

High

314659

CARME
Carnosine N-methyltransferase

2

0

High-throughput

0.585

High

314679

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

2

0

High-throughput

0.585

High

314622

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

314670

FUBP2
Far upstream element-binding protein 2

2

0

Small-scale

0.559

High

180185

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

272957

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

314601

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

314608

CSTF2
Cleavage stimulation factor subunit 2

1

1

Small-scale

0.536

High

314617

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

314621

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

314627

PRR3
Proline-rich protein 3

1

1

High-throughput

0.536

High

314628

SRSF2
Serine/arginine-rich splicing factor 2

1

1

High-throughput

0.536

High

314636

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

314660

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

314661

ZBT44
Zinc finger and BTB domain-containing protein 44

1

1

High-throughput

0.536

High

314704

RBM19
Probable RNA-binding protein 19

1

2

High-throughput

0.536

High

314632

NCBP1
Nuclear cap-binding protein subunit 1

1

0

Small-scale

0.527

High

314611

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

314619

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

314620

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

314644

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

0

High-throughput

0.513

High

314654

ZN677
Zinc finger protein 677

1

0

High-throughput

0.513

High

314656

DHX37
Probable ATP-dependent RNA helicase DHX37

1

0

High-throughput

0.513

High

314658

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

314664

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

314666

DOK4
Docking protein 4

1

0

High-throughput

0.513

High

314667

ANR49
Ankyrin repeat domain-containing protein 49

1

0

High-throughput

0.513

High

314677

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.513

High

314680

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.513

High

314688

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

314698

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

314702

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.513

High

314615

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

314641

UBE3C
Ubiquitin-protein ligase E3C

1

1

High-throughput

0.489

High

314602

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

314612

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.480

High

179507

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

226148

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

256191

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

High-throughput

0.479

High

261362

NCOR1
Nuclear receptor corepressor 1

1

1

High-throughput

0.479

High

314593

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

314597

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

314598

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.479

High

314600

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

314606

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.479

High

314607

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

314613

RBM5
RNA-binding protein 5

1

2

High-throughput

0.479

High

314618

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

314624

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

314625

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.479

High

314630

CSTF1
Cleavage stimulation factor subunit 1

1

2

Small-scale

0.479

High

314633

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

314634

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.479

High

314635

CSTF3
Cleavage stimulation factor subunit 3

1

2

High-throughput

0.479

High

314640

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

314648

BCOR
BCL-6 corepressor

1

1

High-throughput

0.479

High

314649

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

314651

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

314653

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

314662

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

314663

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

314665

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

1

High-throughput

0.479

High

314673

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

High-throughput

0.479

High

314682

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

3

High-throughput

0.479

High

314686

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

314695

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

314701

RL26L
Ribosomal protein uL24-like

1

1

High-throughput

0.479

High

314705

NCOR2
Nuclear receptor corepressor 2

1

1

High-throughput

0.479

High

133271

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

243749

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

314594

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

314599

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

314604

PABP1
Polyadenylate-binding protein 1

1

0

Small-scale

0.458

High

314605

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

314610

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

314614

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

314616

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

314623

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

314626

H31
Histone H3.1

1

0

High-throughput

0.458

High

314637

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

314639

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.458

High

314643

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.458

High

314647

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

314652

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

314655

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

314668

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

314669

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

314671

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

314672

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.458

High

314674

GWL
Serine/threonine-protein kinase greatwall

1

0

High-throughput

0.458

High

314678

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

314681

NADAP
Kanadaptin

1

0

High-throughput

0.458

High

314684

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

314685

RENT2
Regulator of nonsense transcripts 2

1

0

Small-scale

0.458

High

314689

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.458

High

314690

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

314693

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

314694

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

314696

TRPS1
Zinc finger transcription factor Trps1

1

0

High-throughput

0.458

High

314697

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

314699

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

314703

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

314596

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

314675

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.438

High

314609

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

314631

PIGF
Phosphatidylinositol-glycan biosynthesis class F protein

1

0

High-throughput

0.279

Low

314650

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

314657

LGI2
Leucine-rich repeat LGI family member 2

1

0

High-throughput

0.279

Low

314691

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

314683

SPC1L
Speriolin-like protein

1

0

High-throughput

0.265

Low

314692

PALS2
Protein PALS2

1

0

High-throughput

0.251

Low

314603

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

0

High-throughput

0.249

Low

314700

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.249

Low

314645

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024