Protein: CASPE
Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]

Gene: CASPE, CASP14
Organism: Homo sapiens
Interactions: 158
UniProt ID: P31944

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

386181

P53
Cellular tumor antigen p53

3

5

Small-scale

0.640

High

683091

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.628

High

528639

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

Small-scale

0.624

High

667431

CASP1
Caspase-1

1

17

Small-scale

0.618

High

683049

CASP2
Caspase-2

1

17

Small-scale

0.618

High

683053

CASP4
Caspase-4

1

18

Small-scale

0.618

High

683085

CASP8
Caspase-8

1

17

Small-scale

0.618

High

683121

CASPA
Caspase-10

1

17

Small-scale

0.618

High

365158

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

683156

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

683048

CCNF
Cyclin-F

2

1

High-throughput

0.601

High

596253

FILA
Filaggrin

2

4

Small-scale

0.595

High

676728

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

2

0

Small-scale

0.585

High

346049

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

683151

ZRAN1
Ubiquitin thioesterase ZRANB1

2

10

High-throughput

0.584

High

683147

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

683056

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.573

High

683093

RHG29
Rho GTPase-activating protein 29

2

1

High-throughput

0.571

High

683115

ARH40
Rho guanine nucleotide exchange factor 40

2

2

High-throughput

0.571

High

265607

E2F6
Transcription factor E2F6

1

1

High-throughput

0.536

High

518260

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

584558

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

High-throughput

0.536

High

586586

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.536

High

624402

CCNC
Cyclin-C

1

2

High-throughput

0.536

High

683051

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.536

High

683055

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.536

High

683057

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

4

High-throughput

0.536

High

683075

ZN154
Zinc finger protein 154

1

1

High-throughput

0.536

High

683076

CUL2
Cullin-2

1

5

High-throughput

0.536

High

683100

JADE1
Protein Jade-1

1

2

High-throughput

0.536

High

683105

ZN550
Zinc finger protein 550

1

2

High-throughput

0.536

High

683106

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

1

High-throughput

0.536

High

683114

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

1

High-throughput

0.536

High

683141

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.536

High

683157

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.536

High

213692

LIAS
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.513

High

217545

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.513

High

565884

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

683046

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

683060

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

683061

DSCR6
Protein ripply3

1

0

High-throughput

0.513

High

683066

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

683081

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.513

High

683087

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

683104

APTX
Aprataxin

1

0

High-throughput

0.513

High

683110

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.513

High

683111

COA5
Cytochrome c oxidase assembly factor 5

1

0

High-throughput

0.513

High

683112

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

683116

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.513

High

683122

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

683126

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

683130

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

683140

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

683145

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.513

High

683154

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

683063

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

683159

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.501

High

683127

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

209317

TSN6
Tetraspanin-6

1

1

High-throughput

0.489

High

683084

GPR18
N-arachidonyl glycine receptor

1

1

High-throughput

0.489

High

133893

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

226643

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

282547

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.479

High

369069

ESR1
Estrogen receptor

1

5

High-throughput

0.479

High

379059

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

396689

S10A8
Protein S100-A8

1

4

High-throughput

0.479

High

416362

S10A9
Protein S100-A9

1

5

High-throughput

0.479

High

427050

CATD
Cathepsin D

1

1

High-throughput

0.479

High

427464

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

428558

INVO
Involucrin

1

1

High-throughput

0.479

High

503531

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

542205

PLAK
Junction plakoglobin

1

2

High-throughput

0.479

High

551617

DESP
Desmoplakin

1

5

High-throughput

0.479

High

667918

SPB3
Serpin B3

1

8

High-throughput

0.479

High

678412

S10A7
Protein S100-A7

1

5

High-throughput

0.479

High

683045

1433S
14-3-3 protein sigma

1

4

High-throughput

0.479

High

683047

SPB5
Serpin B5

1

8

High-throughput

0.479

High

683064

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

683067

DSG1
Desmoglein-1

1

3

High-throughput

0.479

High

683069

SOX4
Transcription factor SOX-4

1

2

High-throughput

0.479

High

683070

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.479

High

683071

DSC1
Desmocollin-1

1

2

High-throughput

0.479

High

683073

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.479

High

683077

CUL4A
Cullin-4A

1

5

High-throughput

0.479

High

683078

PKP1
Plakophilin-1

1

4

High-throughput

0.479

High

683079

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.479

High

683080

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.479

High

683083

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

10

High-throughput

0.479

High

683086

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

683088

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

683090

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

683094

FILA2
Filaggrin-2

1

4

High-throughput

0.479

High

683113

MET23
Histone-arginine methyltransferase METTL23

1

1

High-throughput

0.479

High

683119

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

20

High-throughput

0.479

High

683120

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

683125

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

683129

SPB12
Serpin B12

1

8

High-throughput

0.479

High

683132

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

683133

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

683136

PRD14
PR domain zinc finger protein 14

1

4

Small-scale

0.479

High

683137

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

Small-scale

0.479

High

683139

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

683144

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

683146

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

2

High-throughput

0.479

High

683155

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.479

High

683158

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

683103

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

2

High-throughput

0.470

High

164106

ARHGA
Rho guanine nucleotide exchange factor 10

1

0

High-throughput

0.458

High

396201

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

551476

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

608892

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.458

High

629097

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.458

High

683054

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

683065

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

683068

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

683089

CDSN
Corneodesmosin

1

0

High-throughput

0.458

High

683095

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

683096

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

683097

KPLCE
Protein KPLCE

1

0

High-throughput

0.458

High

683099

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

683101

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

683108

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

683123

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

Small-scale

0.458

High

683138

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

683149

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

683150

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.458

High

683152

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

683153

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

496414

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.445

High

683058

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

683074

IFT88
Intraflagellar transport protein 88 homolog

1

2

High-throughput

0.445

High

683143

ISK5
Serine protease inhibitor Kazal-type 5

1

3

Small-scale

0.445

High

683135

DDX24
ATP-dependent RNA helicase DDX24

1

6

High-throughput

0.437

High

200811

ZSC12
Zinc finger and SCAN domain-containing protein 12

1

0

High-throughput

0.426

High

683050

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

683072

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

683082

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

683062

CD81
CD81 antigen

1

1

Small-scale

0.407

High

274945

RENR
Renin receptor

1

0

High-throughput

0.279

Low

303660

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

392922

IFNA4
Interferon alpha-4

1

0

High-throughput

0.279

Low

683052

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

683059

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

0

High-throughput

0.279

Low

683092

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

683102

AMTN
Amelotin

1

0

High-throughput

0.279

Low

683107

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.279

Low

683109

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.279

Low

683118

ITLN2
Intelectin-2

1

0

High-throughput

0.279

Low

683124

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

683128

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

683131

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

683142

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

362867

FINC
Fibronectin

1

0

Small-scale

0.249

Low

429299

SAP
Prosaposin

1

0

Small-scale

0.249

Low

683117

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low

683134

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

683148

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

683098

RNLS
Renalase

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024