Protein: TGM5
Protein-glutamine gamma-glutamyltransferase 5 (EC 2.3.2.13) (Transglutaminase X) (TG(X)) (TGX) (TGase X) (Transglutaminase-5) (TGase-5)

Gene: TGM5
Organism: Homo sapiens
Interactions: 40
UniProt ID: O43548

Gene Ontology (top 5):
GO:0003810 - protein-glutamine gamma-glutamyltransferase activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0008544 - epidermis development
GO:0036211 - protein modification process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220089

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

2

High-throughput

0.783

High

220073

FRIH
Ferritin heavy chain

2

2

High-throughput

0.628

High

220074

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

2

High-throughput

0.628

High

220099

MITOK
Mitochondrial potassium channel

3

2

High-throughput

0.609

High

220078

LEG7
Galectin-7

2

1

High-throughput

0.606

High

220084

GRB7
Growth factor receptor-bound protein 7

2

3

High-throughput

0.606

High

220085

RFTN1
Raftlin

2

0

High-throughput

0.602

High

220094

SPICE
Spindle and centriole-associated protein 1

2

0

High-throughput

0.602

High

220100

RBM41
RNA-binding protein 41

2

1

High-throughput

0.553

High

220069

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

220072

RENR
Renin receptor

1

2

High-throughput

0.536

High

220076

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.536

High

220077

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

2

High-throughput

0.536

High

220081

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

220083

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

130891

HIP1
Huntingtin-interacting protein 1

1

2

High-throughput

0.515

High

220075

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

220080

CASP6
Caspase-6

1

2

High-throughput

0.515

High

220092

NEK8
Serine/threonine-protein kinase Nek8

1

0

High-throughput

0.513

High

220087

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.489

High

220093

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.489

High

220101

DOCK7
Dedicator of cytokinesis protein 7

1

2

High-throughput

0.489

High

220103

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

4

High-throughput

0.489

High

220104

TSSP
Thymus-specific serine protease

1

2

High-throughput

0.489

High

220079

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

220097

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

220071

PR40A
Pre-mRNA-processing factor 40 homolog A

1

5

High-throughput

0.470

High

220090

Q6P4E2
LARP4 protein

1

2

High-throughput

0.470

High

220096

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

220107

PALD
Paladin

1

0

High-throughput

0.458

High

220082

COAA1

1

5

High-throughput

0.445

High

220091

LARP4
La-related protein 4

1

2

High-throughput

0.439

High

220086

EEA1
Early endosome antigen 1

1

1

High-throughput

0.437

High

220070

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

220088

PDZ11
PDZ domain-containing protein 11

2

0

High-throughput

0.328

High

220102

INT14
Integrator complex subunit 14

2

0

High-throughput

0.328

High

220105

BCD1
Box C/D snoRNA protein 1

2

0

High-throughput

0.328

High

220095

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

220098

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

220106

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025