Protein: IF4E2
Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)

Gene: IF4E2, EIF4E2
Organism: Homo sapiens
Interactions: 242
UniProt ID: O60573

Gene Ontology (top 5):
GO:0000339 - RNA cap binding
GO:0000340 - RNA 7-methylguanosine cap binding
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252175

4ET
Eukaryotic translation initiation factor 4E transporter

8

2

Small-scale

0.973

High

252059

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

5

15

Small-scale

0.935

High

251167

4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3

2

15

High-throughput

0.817

High

252060

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

2

15

High-throughput

0.811

High

252090

GGYF2
GRB10-interacting GYF protein 2

10

9

Small-scale

0.758

High

251990

GGYF1
GRB10-interacting GYF protein 1

8

9

Small-scale

0.755

High

252038

1433G
14-3-3 protein gamma

4

5

High-throughput

0.697

High

252050

1433F
14-3-3 protein eta

4

5

High-throughput

0.687

High

252126

DI3L1
DIS3-like exonuclease 1

3

2

Small-scale

0.650

High

252206

ARI1
E3 ubiquitin-protein ligase ARIH1

2

3

Small-scale

0.636

High

252076

UBX11
UBX domain-containing protein 11

2

1

High-throughput

0.633

High

60482

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

1

High-throughput

0.628

High

252019

1433B
14-3-3 protein beta/alpha

2

5

High-throughput

0.628

High

131250

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

3

High-throughput

0.611

High

252041

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.611

High

252155

WDR83
WD repeat domain-containing protein 83

3

2

High-throughput

0.609

High

252104

ZN598
E3 ubiquitin-protein ligase ZNF598

3

0

Small-scale

0.606

High

252025

HD
Huntingtin

2

0

High-throughput

0.594

High

252040

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.585

High

252109

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

1

High-throughput

0.584

High

252006

MYOG
Myogenin

2

1

High-throughput

0.573

High

252000

K1C19
Keratin, type I cytoskeletal 19

1

3

High-throughput

0.573

High

252005

TRI27
Zinc finger protein RFP

1

2

High-throughput

0.573

High

252035

KR108
Keratin-associated protein 10-8

1

3

High-throughput

0.573

High

252036

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.573

High

252070

K1H1
Keratin, type I cuticular Ha1

1

5

High-throughput

0.573

High

252082

K1C40
Keratin, type I cytoskeletal 40

1

5

High-throughput

0.573

High

252159

TRI54
Tripartite motif-containing protein 54

1

5

High-throughput

0.573

High

252161

PRD14
PR domain zinc finger protein 14

1

1

High-throughput

0.573

High

252199

AMOL2
Angiomotin-like protein 2

1

1

High-throughput

0.573

High

252204

HBS1L
HBS1-like protein

2

2

High-throughput

0.571

High

221069

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.549

High

252048

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.549

High

252049

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

252098

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

252100

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.549

High

252110

HOMEZ
Homeobox and leucine zipper protein Homez

1

0

High-throughput

0.549

High

252143

SPAG5
Sperm-associated antigen 5

1

0

High-throughput

0.549

High

252154

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.549

High

252163

CARD9
Caspase recruitment domain-containing protein 9

1

0

High-throughput

0.549

High

252196

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.549

High

252211

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.549

High

252022

K1C20
Keratin, type I cytoskeletal 20

1

4

High-throughput

0.541

High

252151

KR412
Keratin-associated protein 4-12

1

3

High-throughput

0.541

High

252148

MDFI
MyoD family inhibitor

1

0

High-throughput

0.536

High

220069

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

1

High-throughput

0.536

High

252010

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

252011

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.536

High

252013

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

252018

S10A7
Protein S100-A7

1

1

High-throughput

0.536

High

252042

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.536

High

252056

CDC16
Cell division cycle protein 16 homolog

1

1

High-throughput

0.536

High

252057

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.536

High

252102

S1A7A
Protein S100-A7A

1

1

High-throughput

0.536

High

252135

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

252158

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

252171

EXOS5
Exosome complex component RRP46

1

4

High-throughput

0.536

High

252177

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.536

High

252089

ATL4
ADAMTS-like protein 4

1

2

High-throughput

0.523

High

252205

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.515

High

252034

KR105
Keratin-associated protein 10-5

1

3

High-throughput

0.515

High

191270

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

251996

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

252014

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

252028

ATX1
Ataxin-1

1

0

High-throughput

0.513

High

252083

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

252085

CAN13
Calpain-13

1

0

High-throughput

0.513

High

252117

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

252166

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

252172

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.513

High

252178

HOME3
Homer protein homolog 3

1

0

High-throughput

0.513

High

251993

ARI2
E3 ubiquitin-protein ligase ARIH2

1

3

Small-scale

0.501

High

251998

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

252149

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.500

High

252157

RBM4
RNA-binding protein 4

1

4

Small-scale

0.500

High

252147

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.489

High

252207

NGN3
Neurogenin-3

1

1

High-throughput

0.489

High

252004

K1C13
Keratin, type I cytoskeletal 13

1

4

High-throughput

0.481

High

252001

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

252122

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

169841

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

172311

XPO1
Exportin-1

1

2

High-throughput

0.479

High

230486

KIF1C
Kinesin-like protein KIF1C

1

2

High-throughput

0.479

High

245181

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

2

High-throughput

0.479

High

245821

KIF1B
Kinesin-like protein KIF1B

1

2

High-throughput

0.479

High

251989

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.479

High

251992

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

251995

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

252002

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

252009

NF1
Neurofibromin

1

1

High-throughput

0.479

High

252012

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.479

High

252016

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

252017

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

252020

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.479

High

252024

MTREX
Exosome RNA helicase MTR4

1

2

High-throughput

0.479

High

252026

PRC2A
Protein PRRC2A

1

1

High-throughput

0.479

High

252029

AFAD
Afadin

1

3

High-throughput

0.479

High

252031

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

252032

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

252037

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

252039

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

252045

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.479

High

252046

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

252051

EXOS9
Exosome complex component RRP45

1

3

High-throughput

0.479

High

252054

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

High-throughput

0.479

High

252058

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

252061

EXOS2
Exosome complex component RRP4

1

1

High-throughput

0.479

High

252063

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

4

Small-scale

0.479

High

252064

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.479

High

252065

UBP2L
Ubiquitin-associated protein 2-like

1

1

High-throughput

0.479

High

252068

EXOS7
Exosome complex component RRP42

1

3

High-throughput

0.479

High

252069

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

252071

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.479

High

252074

EXOS6
Exosome complex component MTR3

1

5

High-throughput

0.479

High

252079

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

252080

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.479

High

252084

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.479

High

252087

LARP1
La-related protein 1

1

4

High-throughput

0.479

High

252093

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

252099

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.479

High

252101

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

252107

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.479

High

252108

KSR1
Kinase suppressor of Ras 1

1

1

High-throughput

0.479

High

252111

RPTOR
Regulatory-associated protein of mTOR

1

3

High-throughput

0.479

High

252119

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

High-throughput

0.479

High

252121

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

252124

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

252127

HDAC7
Histone deacetylase 7

1

1

High-throughput

0.479

High

252129

SRS12
Serine/arginine-rich splicing factor 12

1

4

High-throughput

0.479

High

252134

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

252136

EXOS8
Exosome complex component RRP43

1

3

High-throughput

0.479

High

252142

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.479

High

252152

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

252164

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

252167

PKHA5
Pleckstrin homology domain-containing family A member 5

1

4

High-throughput

0.479

High

252169

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

3

High-throughput

0.479

High

252170

EXOS4
Exosome complex component RRP41

1

4

High-throughput

0.479

High

252173

KI13B
Kinesin-like protein KIF13B

1

2

High-throughput

0.479

High

252179

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

252185

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

252187

NGAP
Ras GTPase-activating protein nGAP

1

1

High-throughput

0.479

High

252188

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

252189

FBW1B
F-box/WD repeat-containing protein 11

1

3

High-throughput

0.479

High

252195

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.479

High

252197

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.479

High

252198

NINL
Ninein-like protein

1

1

High-throughput

0.479

High

252201

EXOS1
Exosome complex component CSL4

1

2

High-throughput

0.479

High

252203

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.479

High

252208

RBM7
RNA-binding protein 7

1

3

High-throughput

0.479

High

252210

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

49873

A1A4E9
Keratin 13

1

4

High-throughput

0.470

High

128654

MEN1
Menin

1

0

High-throughput

0.458

High

163017

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

176788

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.458

High

208604

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

251987

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

251994

NADK
NAD kinase

1

0

High-throughput

0.458

High

251997

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

252008

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

252023

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

252027

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.458

High

252033

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

252043

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

0

Small-scale

0.458

High

252047

EXOSX
Exosome complex component 10

1

0

High-throughput

0.458

High

252053

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

252055

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.458

High

252062

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.458

High

252067

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

252078

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.458

High

252086

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.458

High

252091

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

252092

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

252103

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.458

High

252106

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

0

High-throughput

0.458

High

252120

NAV1
Neuron navigator 1

1

0

High-throughput

0.458

High

252130

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

252131

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

252133

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

252138

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

252140

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

252141

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

252144

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

252146

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.458

High

252150

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

252156

RTKN
Rhotekin

1

0

High-throughput

0.458

High

252160

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

252165

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

252174

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

252176

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

252181

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.458

High

252182

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

252186

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

252191

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

252192

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

252202

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

187832

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

3

High-throughput

0.445

High

252030

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.437

High

252066

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.437

High

252081

AN34A
Ankyrin repeat domain-containing protein 34A

1

3

High-throughput

0.437

High

252094

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.437

High

252096

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.437

High

252097

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

252113

NIN
Ninein

1

1

High-throughput

0.437

High

252125

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

1

High-throughput

0.437

High

252128

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.437

High

252132

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

252168

TANC2
Protein TANC2

1

2

High-throughput

0.437

High

252209

KCTD3
BTB/POZ domain-containing protein KCTD3

1

1

High-throughput

0.437

High

252077

HECD3
E3 ubiquitin-protein ligase HECTD3

1

2

High-throughput

0.407

High

252088

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

252137

ZBTB9
Zinc finger and BTB domain-containing protein 9

2

0

High-throughput

0.327

High

251991

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.299

High

252007

ITF2
Transcription factor 4

1

0

High-throughput

0.299

High

252052

TLE5
TLE family member 5

1

0

High-throughput

0.299

High

252095

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.299

High

252114

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.299

High

252115

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

252123

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.299

High

252003

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

252044

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

252075

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

252105

URP2
Fermitin family homolog 3

1

0

High-throughput

0.279

Low

252116

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

252139

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

252145

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

252162

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.279

Low

252190

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

252193

CELA1
Chymotrypsin-like elastase family member 1

1

0

High-throughput

0.279

Low

251988

TMCC2
Transmembrane and coiled-coil domains protein 2

1

0

High-throughput

0.251

Low

252073

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

251999

INHBA
Inhibin beta A chain

1

0

High-throughput

0.249

Low

252015

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

252021

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

252072

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

252112

CCNQ
Cyclin-Q

1

0

High-throughput

0.249

Low

252118

RN214
RING finger protein 214

1

0

High-throughput

0.249

Low

252153

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

252180

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

252183

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

252184

CING
Cingulin

1

0

High-throughput

0.249

Low

252194

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.249

Low

252200

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025