Protein: PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)

Gene: PDP1
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9P0J1

Gene Ontology (top 5):
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004741 - [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1448692

LATS2
Serine/threonine-protein kinase LATS2

1

5

High-throughput

0.691

High

1096511

PAK1
Serine/threonine-protein kinase PAK 1

2

16

High-throughput

0.659

High

1419664

RM37
Large ribosomal subunit protein mL37

3

0

High-throughput

0.638

High

724210

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

2

1

High-throughput

0.628

High

471295

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

3

0

Small-scale

0.623

High

1051976

KPCD
Protein kinase C delta type

1

4

Small-scale

0.618

High

1335931

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

2

0

High-throughput

0.602

High

243164

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

666374

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

Small-scale

0.578

High

1449509

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

4

Small-scale

0.578

High

1452031

TRM1
tRNA

2

0

High-throughput

0.576

High

318097

PKHG5
Pleckstrin homology domain-containing family G member 5

2

1

High-throughput

0.574

High

554261

BMP4
Bone morphogenetic protein 4

2

1

High-throughput

0.574

High

1208594

SMAG2
Protein Smaug homolog 2

2

1

High-throughput

0.574

High

1279587

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

2

1

High-throughput

0.574

High

388806

C1QC
Complement C1q subcomponent subunit C

2

1

High-throughput

0.549

High

1155048

ADIPO
Adiponectin

2

1

High-throughput

0.549

High

282117

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.536

High

539430

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

560927

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.536

High

1083786

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.536

High

962574

RHOA
Transforming protein RhoA

2

2

High-throughput

0.521

High

884717

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1106461

TOP3A
DNA topoisomerase 3-alpha

1

0

High-throughput

0.513

High

1108888

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

1

0

High-throughput

0.513

High

1138902

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1163554

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.513

High

1335525

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.513

High

1453768

COR1C
Coronin-1C

1

0

High-throughput

0.513

High

186084

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

363948

EGFR
Epidermal growth factor receptor

1

16

Small-scale

0.501

High

168908

PLD2
Phospholipase D2

1

2

High-throughput

0.489

High

1028900

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.489

High

1117513

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.489

High

1122960

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

3

High-throughput

0.489

High

1402157

RB40C
Ras-related protein Rab-40C

1

8

High-throughput

0.489

High

1431614

IL25
Interleukin-25

1

1

High-throughput

0.489

High

1453769

SMAG1
Protein Smaug homolog 1

1

1

High-throughput

0.489

High

404491

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

1142692

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1420417

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

1

Small-scale

0.479

High

1453770

PKP3
Plakophilin-3

1

1

High-throughput

0.470

High

1232615

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

279957

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

1161420

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1207172

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

541725

FGFR1
Fibroblast growth factor receptor 1

1

10

Small-scale

0.457

High

1104148

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.445

High

1453767

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.445

High

1453772

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

4

High-throughput

0.445

High

894214

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

1448507

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

538032

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

1015864

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

1241820

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.437

High

1255877

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1453766

XPO7
Exportin-7

1

2

High-throughput

0.437

High

437810

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

628661

CAP7
Azurocidin

1

3

High-throughput

0.407

High

326840

SPN1
Snurportin-1

3

0

High-throughput

0.347

High

766129

PCGF2
Polycomb group RING finger protein 2

2

0

High-throughput

0.328

High

1081502

INCA1
Protein INCA1

2

0

High-throughput

0.316

High

1186718

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

216197

MTG8R
Protein CBFA2T2

1

0

High-throughput

0.299

High

702199

LYOX
Protein-lysine 6-oxidase

1

0

High-throughput

0.279

Low

1206347

WDR44
WD repeat-containing protein 44

1

0

High-throughput

0.279

Low

1249689

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

1280281

AP2D
Transcription factor AP-2-delta

1

0

High-throughput

0.279

Low

1328586

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1449184

CHST7
Carbohydrate sulfotransferase 7

1

0

High-throughput

0.279

Low

1452626

DLL3
Delta-like protein 3

1

0

High-throughput

0.279

Low

63143

CL18A
C-type lectin domain family 18 member A

1

0

High-throughput

0.249

Low

295546

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

High-throughput

0.232

Low

1239323

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1366281

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

1400782

MYCT
Proton myo-inositol cotransporter

1

0

High-throughput

0.232

Low

1449189

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.232

Low

1453765

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.232

Low

1453771

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025