Protein: RPC8
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)

Gene: RPC8, POLR3H
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9Y535

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1451015

RPC2
DNA-directed RNA polymerase III subunit RPC2

5

11

Small-scale

0.919

High

959100

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

5

High-throughput

0.903

High

165115

RPC1
DNA-directed RNA polymerase III subunit RPC1

4

12

High-throughput

0.895

High

287496

RPC9
DNA-directed RNA polymerase III subunit RPC9

3

5

High-throughput

0.861

High

1450831

RPC5
DNA-directed RNA polymerase III subunit RPC5

8

2

High-throughput

0.749

High

430663

RPC4
DNA-directed RNA polymerase III subunit RPC4

7

2

Small-scale

0.746

High

622018

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

4

High-throughput

0.704

High

180444

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

4

8

High-throughput

0.699

High

1413124

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

4

1

High-throughput

0.697

High

186387

RPC7
DNA-directed RNA polymerase III subunit RPC7

4

1

Small-scale

0.694

High

912161

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

4

5

High-throughput

0.694

High

983736

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

4

High-throughput

0.691

High

1414288

RPC3
DNA-directed RNA polymerase III subunit RPC3

3

1

High-throughput

0.667

High

1491001

RPC10
DNA-directed RNA polymerase III subunit RPC10

3

9

High-throughput

0.650

High

668089

CDK2
Cyclin-dependent kinase 2

3

0

High-throughput

0.638

High

1431043

RPC6
DNA-directed RNA polymerase III subunit RPC6

2

1

High-throughput

0.628

High

192886

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

4

High-throughput

0.618

High

340068

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

12

High-throughput

0.618

High

667523

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

High-throughput

0.618

High

723151

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

11

High-throughput

0.618

High

976182

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

2

High-throughput

0.618

High

1437329

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

11

High-throughput

0.618

High

516891

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

5

High-throughput

0.611

High

923572

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

4

High-throughput

0.611

High

1460109

GPN3
GPN-loop GTPase 3

3

4

High-throughput

0.609

High

1328090

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.580

High

957572

UBC12
NEDD8-conjugating enzyme Ubc12

2

0

High-throughput

0.576

High

64445

BDP1
Transcription factor TFIIIB component B'' homolog

1

1

High-throughput

0.536

High

272781

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

High-throughput

0.536

High

442967

PRGR
Progesterone receptor

1

2

High-throughput

0.536

High

628865

TBP
TATA-box-binding protein

1

1

High-throughput

0.536

High

896340

PEX5
Peroxisomal targeting signal 1 receptor

1

2

High-throughput

0.536

High

1217937

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

1

High-throughput

0.536

High

1385095

UPP
Uracil phosphoribosyltransferase homolog

1

1

High-throughput

0.536

High

1439347

GPN1
GPN-loop GTPase 1

1

4

High-throughput

0.536

High

177081

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.513

High

214637

WDR62
WD repeat-containing protein 62

1

0

High-throughput

0.513

High

279007

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.513

High

296082

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

0

High-throughput

0.513

High

488031

DPOLA
DNA polymerase alpha catalytic subunit

1

0

High-throughput

0.513

High

885568

PRI1
DNA primase small subunit

1

0

High-throughput

0.513

High

885615

PRI2
DNA primase large subunit

1

0

High-throughput

0.513

High

1026607

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.513

High

1081664

HSP7E
Heat shock 70 kDa protein 14

1

0

High-throughput

0.513

High

1112818

CUL1
Cullin-1

1

0

High-throughput

0.513

High

1139043

SNX17
Sorting nexin-17

1

0

High-throughput

0.513

High

1187965

PTHB1
Protein PTHB1

1

0

High-throughput

0.513

High

1287297

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.513

High

1316497

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.513

High

1322687

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.513

High

1326175

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

1449171

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

1491310

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

191180

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

316467

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

High-throughput

0.479

High

621805

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

8

High-throughput

0.479

High

787816

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

9

High-throughput

0.479

High

912263

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

5

High-throughput

0.479

High

1007810

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.479

High

1217641

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

5

High-throughput

0.479

High

1313080

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

2

High-throughput

0.479

High

1399384

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

7

High-throughput

0.479

High

1428689

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1435205

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

1446568

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.479

High

1447106

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

8

High-throughput

0.479

High

1454151

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

10

High-throughput

0.479

High

1458464

UXT
Protein UXT

1

1

High-throughput

0.479

High

1460103

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

535712

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

551357

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

972178

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

1147029

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.458

High

1432846

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.458

High

1232046

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

1

High-throughput

0.437

High

1398633

DAA10
Dynein axonemal assembly factor 10

1

1

High-throughput

0.437

High

1449791

PDRG1
p53 and DNA damage-regulated protein 1

1

1

High-throughput

0.437

High

1451340

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

516814

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

664917

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

1090327

ELAV2
ELAV-like protein 2

3

0

High-throughput

0.345

High

1178127

RFX7
DNA-binding protein RFX7

1

0

High-throughput

0.279

Low

1275525

TRM1L
tRNA

1

0

High-throughput

0.279

Low

1337812

DP13B
DCC-interacting protein 13-beta

1

0

High-throughput

0.279

Low

1435216

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.279

Low

182215

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.249

Low

516738

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025