Protein: DKK3
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)

Gene: DKK3
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9UBP4

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0009653 - anatomical structure morphogenesis
GO:0016055 - Wnt signaling pathway
GO:0017015 - regulation of transforming growth factor beta receptor signaling pathway
GO:0030325 - adrenal gland development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335406

GDF11
Growth/differentiation factor 11

2

1

High-throughput

0.628

High

945917

INHBE
Inhibin beta E chain

2

1

High-throughput

0.628

High

1316892

ASPM
Abnormal spindle-like microcephaly-associated protein

3

6

High-throughput

0.604

High

1458598

MYO5A
Unconventional myosin-Va

3

3

High-throughput

0.604

High

183306

LAMA5
Laminin subunit alpha-5

2

0

High-throughput

0.602

High

987492

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

0

High-throughput

0.602

High

1311046

SULF2
Extracellular sulfatase Sulf-2

2

0

High-throughput

0.602

High

1433627

SMOC1
SPARC-related modular calcium-binding protein 1

2

0

High-throughput

0.602

High

774810

TIMP3
Metalloproteinase inhibitor 3

2

0

High-throughput

0.576

High

318411

MYO1D
Unconventional myosin-Id

2

3

High-throughput

0.574

High

425065

ADT2
ADP/ATP translocase 2

2

1

High-throughput

0.574

High

552427

ADT3
ADP/ATP translocase 3

2

1

High-throughput

0.574

High

593620

GDC
Solute carrier family 25 member 16

2

2

High-throughput

0.574

High

1212158

ATD3C
ATPase family AAA domain-containing protein 3C

2

1

High-throughput

0.574

High

1393263

SENP5
Sentrin-specific protease 5

2

1

High-throughput

0.574

High

1397188

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

2

1

High-throughput

0.574

High

1447562

MYO5C
Unconventional myosin-Vc

2

2

High-throughput

0.574

High

1458593

MYO5B
Unconventional myosin-Vb

2

2

High-throughput

0.574

High

1106240

MYO9B
Unconventional myosin-IXb

2

4

High-throughput

0.549

High

668740

APC
Adenomatous polyposis coli protein

1

0

High-throughput

0.518

High

885437

HXA1
Homeobox protein Hox-A1

1

0

High-throughput

0.518

High

1106734

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.518

High

1367491

ESR2
Estrogen receptor beta

1

0

High-throughput

0.518

High

144112

WNT7A
Protein Wnt-7a

1

0

High-throughput

0.513

High

183869

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.513

High

533033

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

891852

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.513

High

1448801

UBQL4
Ubiquilin-4

1

2

High-throughput

0.494

High

274792

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.493

High

74069

MYO9A
Unconventional myosin-IXa

1

4

High-throughput

0.489

High

227993

MYO1B
Unconventional myosin-Ib

1

3

High-throughput

0.489

High

1214824

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.489

High

1392793

P121A
Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.489

High

1454038

SENP1
Sentrin-specific protease 1

1

1

High-throughput

0.489

High

856962

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.470

High

628472

KLK2
Kallikrein-2

1

2

High-throughput

0.445

High

663576

CMA1
Chymase

1

2

High-throughput

0.445

High

1432124

KLK15
Kallikrein-15

1

1

High-throughput

0.445

High

378444

IFNG
Interferon gamma

1

0

High-throughput

0.426

High

469726

MMP3
Stromelysin-1

1

0

High-throughput

0.426

High

709310

CCN2
CCN family member 2

1

0

High-throughput

0.426

High

1458590

ANGL2
Angiopoietin-related protein 2

1

0

High-throughput

0.426

High

1339747

TNIP2
TNFAIP3-interacting protein 2

3

0

High-throughput

0.345

High

1448626

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

3

0

High-throughput

0.345

High

143941

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.328

High

160346

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.328

High

298825

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

2

0

High-throughput

0.328

High

317481

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

2

0

High-throughput

0.328

High

665741

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

0

High-throughput

0.328

High

870006

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

2

0

High-throughput

0.328

High

1063671

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.328

High

1068865

IFFO1
Non-homologous end joining factor IFFO1

2

0

High-throughput

0.328

High

1085482

SRBP2
Sterol regulatory element-binding protein 2

2

0

High-throughput

0.328

High

1097914

STX5
Syntaxin-5

2

0

High-throughput

0.328

High

1143578

PCM1
Pericentriolar material 1 protein

2

0

High-throughput

0.328

High

1186324

MA7D1
MAP7 domain-containing protein 1

2

0

High-throughput

0.328

High

1292245

LONP2
Lon protease homolog 2, peroxisomal

2

0

High-throughput

0.328

High

1370030

GSLG1
Golgi apparatus protein 1

2

0

High-throughput

0.328

High

1410914

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

1448140

CHSTC
Carbohydrate sulfotransferase 12

2

0

High-throughput

0.328

High

1458589

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

2

0

High-throughput

0.328

High

1458596

CP131
Centrosomal protein of 131 kDa

2

0

High-throughput

0.328

High

226901

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

0

High-throughput

0.316

High

170401

AURKA
Aurora kinase A

1

0

High-throughput

0.282

High

186228

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.282

High

294897

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.282

High

296075

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

0

High-throughput

0.282

High

1116092

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.282

High

1277953

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.282

High

164747

HS3S1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

183763

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.279

Low

229168

GTPB6
Putative GTP-binding protein 6

1

0

High-throughput

0.279

Low

316109

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.279

Low

397815

ATP8
ATP synthase F(0) complex subunit 8

1

0

High-throughput

0.279

Low

658451

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.279

Low

1091059

FOXF1
Forkhead box protein F1

1

0

High-throughput

0.279

Low

1293357

CHSS1
Chondroitin sulfate synthase 1

1

0

High-throughput

0.279

Low

1330277

NPW
Neuropeptide W

1

0

High-throughput

0.279

Low

1350197

ALMS1
Centrosome-associated protein ALMS1

1

0

High-throughput

0.279

Low

1458591

PCOC2
Procollagen C-endopeptidase enhancer 2

1

0

High-throughput

0.279

Low

1458592

PKHH1
Pleckstrin homology domain-containing family H member 1

1

0

High-throughput

0.279

Low

1458595

TTF2
Transcription termination factor 2

1

0

High-throughput

0.279

Low

167410

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.268

Low

1458594

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.251

Low

106788

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

556395

CADH1
Cadherin-1

1

0

High-throughput

0.238

Low

1191408

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.232

Low

1228376

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

0

High-throughput

0.232

Low

1273309

CHST3
Carbohydrate sulfotransferase 3

1

0

High-throughput

0.232

Low

1294998

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

High-throughput

0.232

Low

1308308

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.232

Low

1405698

NECD
Necdin

1

0

High-throughput

0.232

Low

1458597

PRG3
Proteoglycan 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025