Protein: CD28
T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28)

Gene: CD28
Organism: Homo sapiens
Interactions: 28
UniProt ID: P10747

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0001819 - positive regulation of cytokine production
GO:0002863 - positive regulation of inflammatory response to antigenic stimulus
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532161

CD80
T-lymphocyte activation antigen CD80

5

9

Small-scale

0.927

High

532162

CD86
T-lymphocyte activation antigen CD86

2

7

Small-scale

0.768

High

532159

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

19

5

Small-scale

0.764

High

532167

GRB2
Growth factor receptor-bound protein 2

5

6

Small-scale

0.709

High

292804

GRAP2
GRB2-related adapter protein 2

3

5

Small-scale

0.687

High

532158

CTLA4
Cytotoxic T-lymphocyte protein 4

1

2

High-throughput

0.575

High

532165

EFNB2
Ephrin-B2

1

1

High-throughput

0.536

High

532168

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.536

High

480662

LEG1
Galectin-1

1

0

High-throughput

0.513

High

532166

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

532169

HBA
Hemoglobin subunit alpha

1

0

High-throughput

0.513

High

532175

O56B4
Olfactory receptor 56B4

1

0

High-throughput

0.493

High

136270

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

11

Small-scale

0.479

High

532157

VAV
Proto-oncogene vav

1

1

Small-scale

0.479

High

532160

1433S
14-3-3 protein sigma

1

2

High-throughput

0.479

High

532163

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

532176

DOK1
Docking protein 1

1

0

Small-scale

0.458

High

532164

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.445

High

532171

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.445

High

532172

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.445

High

532177

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.445

High

532180

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.445

High

532170

KPCT
Protein kinase C theta type

1

0

Small-scale

0.426

High

532178

DIAP3
Protein diaphanous homolog 3

1

0

High-throughput

0.426

High

532173

PXDC2
Plexin domain-containing protein 2

2

0

High-throughput

0.313

High

532174

TM192
Transmembrane protein 192

2

0

High-throughput

0.313

High

326652

DUS14
Dual specificity protein phosphatase 14

1

0

Small-scale

0.299

High

532179

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025