Protein: PCYOX
Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)

Gene: PCYOX, PCYOX1
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q9UHG3

Gene Ontology (top 5):
GO:0001735 - prenylcysteine oxidase activity
GO:0005764 - lysosome
GO:0030327 - prenylated protein catabolic process
GO:0030328 - prenylcysteine catabolic process
GO:0034361 - very-low-density lipoprotein particle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

916207

BIEA
Biliverdin reductase A

3

0

High-throughput

0.638

High

322769

RHBT3
Rho-related BTB domain-containing protein 3

3

0

High-throughput

0.634

High

1042671

UPAR
Urokinase plasminogen activator surface receptor

2

1

High-throughput

0.558

High

1448304

FBX6
F-box only protein 6

2

3

High-throughput

0.558

High

885444

HXA1
Homeobox protein Hox-A1

2

1

High-throughput

0.553

High

1459941

FBX2
F-box only protein 2

2

3

High-throughput

0.549

High

132675

UPK1A
Uroplakin-1a

1

1

High-throughput

0.536

High

387573

APOA2
Apolipoprotein A-II

1

1

High-throughput

0.536

High

533794

CLUS
Clusterin

1

1

High-throughput

0.536

High

699234

CALX
Calnexin

1

4

High-throughput

0.536

High

387669

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.513

High

445089

S10A9
Protein S100-A9

1

0

High-throughput

0.513

High

568007

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

618429

TSN8
Tetraspanin-8

1

0

High-throughput

0.513

High

647415

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.513

High

731908

CEAM8
Cell adhesion molecule CEACAM8

1

0

High-throughput

0.513

High

1015150

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.513

High

1458671

DNJB9
DnaJ homolog subfamily B member 9

1

0

High-throughput

0.513

High

286599

SG2A1
Mammaglobin-B

1

1

High-throughput

0.489

High

288288

SPAG6
Sperm-associated antigen 6

1

1

High-throughput

0.489

High

1448013

CP26B
Cytochrome P450 26B1

1

1

High-throughput

0.489

High

478304

HXD4
Homeobox protein Hox-D4

1

1

High-throughput

0.470

High

154902

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.458

High

387336

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.458

High

1449986

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

1417170

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

106805

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

218923

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

404526

GCR
Glucocorticoid receptor

1

1

Small-scale

0.437

High

566870

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.437

High

1255978

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1383150

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.437

High

1396555

CALR3
Calreticulin-3

1

4

High-throughput

0.437

High

1453021

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

1168621

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

0

High-throughput

0.426

High

1324769

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.426

High

171005

CLGN
Calmegin

1

4

High-throughput

0.407

High

211190

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.407

High

530528

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.407

High

912726

CTR2
Cationic amino acid transporter 2

1

1

High-throughput

0.407

High

1435244

ANTR1
Anthrax toxin receptor 1

3

0

High-throughput

0.347

High

571797

FPPS
Farnesyl pyrophosphate synthase

2

0

High-throughput

0.328

High

1093601

TRDN
Triadin

2

0

High-throughput

0.328

High

1350252

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

2

0

High-throughput

0.328

High

1459942

ENTP4
Ectonucleoside triphosphate diphosphohydrolase 4

2

0

High-throughput

0.328

High

1010118

DLK1
Protein delta homolog 1

2

0

High-throughput

0.318

High

1333719

UBAC2
Ubiquitin-associated domain-containing protein 2

2

0

High-throughput

0.318

High

1153454

CD226
CD226 antigen

2

0

High-throughput

0.313

High

1290438

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

2

0

High-throughput

0.313

High

1459943

UST
Uronyl 2-sulfotransferase

2

0

High-throughput

0.313

High

243217

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.305

High

66949

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

291734

CXB3
Gap junction beta-3 protein

1

0

High-throughput

0.279

Low

426148

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.279

Low

593525

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.279

Low

733457

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

876409

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

906367

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

1251021

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.279

Low

1385214

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1411131

SH23A
SH2 domain-containing protein 3A

1

0

High-throughput

0.279

Low

1417087

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.279

Low

1439087

MAGE1
Melanoma-associated antigen E1

1

0

High-throughput

0.279

Low

1454856

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.279

Low

1459944

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

230585

KIF1C
Kinesin-like protein KIF1C

1

0

High-throughput

0.269

Low

186101

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

589971

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696793

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769445

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

934033

PLTP
Phospholipid transfer protein

1

0

High-throughput

0.249

Low

947304

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

951503

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

1023322

CP4F8
Cytochrome P450 4F8

1

0

High-throughput

0.249

Low

1107310

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

1205501

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1252282

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

1448922

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.249

Low

1453831

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.249

Low

1459818

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

143762

WN10B
Protein Wnt-10b

1

0

High-throughput

0.232

Low

330361

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

532179

CD28
T-cell-specific surface glycoprotein CD28

1

0

High-throughput

0.232

Low

870335

S6A12
Sodium- and chloride-dependent betaine transporter

1

0

High-throughput

0.232

Low

1053083

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.232

Low

1104158

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1180755

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

1245936

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.232

Low

1277557

UBE3B
Ubiquitin-protein ligase E3B

1

0

High-throughput

0.232

Low

1294858

STX12
Syntaxin-12

1

0

High-throughput

0.232

Low

1309411

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

0

High-throughput

0.232

Low

1324801

LAT4
Large neutral amino acids transporter small subunit 4

1

0

High-throughput

0.232

Low

1358217

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

1382678

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

1421370

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.232

Low

1438430

POPD2
Popeye domain-containing protein 2

1

0

High-throughput

0.232

Low

1449909

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.232

Low

1458513

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025