Protein: HINT1
Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)

Gene: HINT1
Organism: Homo sapiens
Interactions: 97
UniProt ID: P49773

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000166 - nucleotide binding
GO:0005080 - protein kinase C binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890181

HINT1
Adenosine 5'-monophosphoramidase HINT1

3

16

Small-scale

0.827

High

890224

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

16

High-throughput

0.691

High

890212

HDAC7
Histone deacetylase 7

3

1

High-throughput

0.667

High

890183

CDK9
Cyclin-dependent kinase 9

3

0

High-throughput

0.638

High

764545

CTNB1
Catenin beta-1

2

2

Small-scale

0.620

High

355167

ACL6A
Actin-like protein 6A

2

1

High-throughput

0.611

High

890218

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

2

0

High-throughput

0.602

High

767697

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.585

High

241092

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

890207

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

0

High-throughput

0.580

High

890232

RUVB2
RuvB-like 2

1

1

Small-scale

0.578

High

890233

RUVB1
RuvB-like 1

1

1

Small-scale

0.578

High

883172

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

Small-scale

0.561

High

303119

RGS20
Regulator of G-protein signaling 20

1

2

Small-scale

0.552

High

890225

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

1

Small-scale

0.552

High

641528

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

0

High-throughput

0.551

High

890188

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.537

High

361170

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

529347

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

890222

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.536

High

890237

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

269098

MITF
Microphthalmia-associated transcription factor

1

0

Small-scale

0.529

High

890185

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.515

High

213863

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

249964

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.513

High

783533

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.513

High

890184

ZN131
Zinc finger protein 131

1

0

High-throughput

0.513

High

890193

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

890201

KDM4D
Lysine-specific demethylase 4D

1

0

High-throughput

0.513

High

890203

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

890211

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

890213

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

890236

AMMR1
Nuclear protein AMMECR1

1

0

High-throughput

0.513

High

787483

GNL1
Guanine nucleotide-binding protein-like 1

1

0

High-throughput

0.493

High

890182

RGS19
Regulator of G-protein signaling 19

1

2

Small-scale

0.481

High

890226

RGS17
Regulator of G-protein signaling 17

1

2

Small-scale

0.481

High

464876

SP1
Transcription factor Sp1

1

0

Small-scale

0.480

High

371477

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

377460

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.479

High

379948

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

405906

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

408737

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.479

High

487089

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

890190

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

890204

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

890209

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

890214

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

890217

SCLT1
Sodium channel and clathrin linker 1

1

1

High-throughput

0.479

High

890227

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

890228

LEF1
Lymphoid enhancer-binding factor 1

1

1

Small-scale

0.479

High

890229

HDAC9
Histone deacetylase 9

1

1

Small-scale

0.479

High

890195

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.460

High

890230

TEN1
Teneurin-1

1

0

Small-scale

0.460

High

259629

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

289955

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

588203

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

606430

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

685453

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

694928

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

715484

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

Small-scale

0.458

High

720970

CLIP1
CAP-Gly domain-containing linker protein 1

1

0

High-throughput

0.458

High

762275

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

791184

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

822533

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

830345

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

833239

PERI
Peripherin

1

0

High-throughput

0.458

High

890186

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

890187

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

890189

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

890192

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

890197

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

890198

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

890202

DEN5A
DENN domain-containing protein 5A

1

0

High-throughput

0.458

High

890205

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

890208

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

890210

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

890215

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.458

High

890219

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

890220

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

890221

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

890223

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.458

High

890234

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

404728

PRIO
Major prion protein

1

1

High-throughput

0.445

High

409310

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

563427

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

890199

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

105575

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

890191

RT25
Small ribosomal subunit protein mS25

1

1

High-throughput

0.437

High

890231

SORC3
VPS10 domain-containing receptor SorCS3

1

1

High-throughput

0.437

High

890206

SFPA2
Pulmonary surfactant-associated protein A2

1

0

High-throughput

0.279

Low

890235

SNX24
Sorting nexin-24

1

0

High-throughput

0.279

Low

418015

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

890194

ABD18
Protein ABHD18

1

0

High-throughput

0.249

Low

890200

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

890216

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

890196

TRI29
Tripartite motif-containing protein 29

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025