Protein: DGAT1
Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)

Gene: DGAT1
Organism: Homo sapiens
Interactions: 51
UniProt ID: O75907

Gene Ontology (top 5):
GO:0003846 - 2-acylglycerol O-acyltransferase activity
GO:0004144 - diacylglycerol O-acyltransferase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006640 - monoacylglycerol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296896

DGAT1
Diacylglycerol O-acyltransferase 1

3

2

Small-scale

0.861

High

296926

SLAF6
SLAM family member 6

1

1

High-throughput

0.691

High

296902

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.656

High

296935

SG196
Protein O-mannose kinase

3

0

High-throughput

0.638

High

296913

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

1

High-throughput

0.628

High

296917

C3AR
C3a anaphylatoxin chemotactic receptor

2

4

High-throughput

0.628

High

296911

CCR9
C-C chemokine receptor type 9

2

4

High-throughput

0.608

High

296905

CTR1
High affinity cationic amino acid transporter 1

2

0

High-throughput

0.602

High

296930

GPR21
Probable G-protein coupled receptor 21

2

0

High-throughput

0.602

High

182436

GP182
G-protein coupled receptor 182

2

5

High-throughput

0.601

High

296908

GPR12
G-protein coupled receptor 12

2

2

High-throughput

0.601

High

296912

CXCR4
C-X-C chemokine receptor type 4

2

4

High-throughput

0.601

High

296900

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

296937

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.546

High

141802

ACKR2
Atypical chemokine receptor 2

1

5

High-throughput

0.536

High

173799

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.536

High

296897

TSN15
Tetraspanin-15

1

2

High-throughput

0.536

High

296904

TSN8
Tetraspanin-8

1

2

High-throughput

0.536

High

296907

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

2

High-throughput

0.536

High

296915

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.536

High

296919

T184A
Transmembrane protein 184A

1

1

High-throughput

0.536

High

296921

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.536

High

296924

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.536

High

296931

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.536

High

296934

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.536

High

296939

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

High-throughput

0.536

High

296901

CD1A
T-cell surface glycoprotein CD1a

1

0

High-throughput

0.518

High

296909

GBRA4
Gamma-aminobutyric acid receptor subunit alpha-4

1

0

High-throughput

0.518

High

296923

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

296927

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

296928

BSCL2
Seipin

1

0

High-throughput

0.513

High

296933

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

217628

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

240315

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

296922

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

296910

CXCR3
C-X-C chemokine receptor type 3

1

4

High-throughput

0.445

High

296920

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

4

High-throughput

0.445

High

296932

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.445

High

296938

TMED5
Transmembrane emp24 domain-containing protein 5

1

1

High-throughput

0.445

High

296918

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

296925

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

296898

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.426

High

296899

APOA2
Apolipoprotein A-II

1

0

Small-scale

0.426

High

296903

SDC1
Syndecan-1

1

0

High-throughput

0.426

High

296914

TRDN
Triadin

1

0

High-throughput

0.426

High

296916

S39AE
Metal cation symporter ZIP14

1

0

High-throughput

0.426

High

296929

TM169
Transmembrane protein 169

1

0

High-throughput

0.426

High

296936

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.426

High

292950

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

296906

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025