Protein: TMED5
Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)

Gene: TMED5
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q9Y3A6

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 - Golgi apparatus
GO:0005801 - cis-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889048

TMEDA
Transmembrane emp24 domain-containing protein 10

7

17

High-throughput

0.958

High

1146662

TMED2
Transmembrane emp24 domain-containing protein 2

4

18

High-throughput

0.900

High

1281281

TMED4
Transmembrane emp24 domain-containing protein 4

2

17

High-throughput

0.776

High

1415433

TMED9
Transmembrane emp24 domain-containing protein 9

2

19

High-throughput

0.776

High

1491123

LIPG
Endothelial lipase

2

5

High-throughput

0.628

High

1132361

GOGB1
Golgin subfamily B member 1

2

3

High-throughput

0.601

High

1330446

EMC1
ER membrane protein complex subunit 1

2

4

High-throughput

0.601

High

1372485

TP4A1
Protein tyrosine phosphatase type IVA 1

2

3

High-throughput

0.601

High

1141083

KIF14
Kinesin-like protein KIF14

2

7

High-throughput

0.549

High

1431642

CHST8
Carbohydrate sulfotransferase 8

2

6

High-throughput

0.549

High

158364

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.536

High

220523

RNF13
E3 ubiquitin-protein ligase RNF13

1

7

High-throughput

0.536

High

261330

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.536

High

483272

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

699281

CALX
Calnexin

1

10

High-throughput

0.536

High

773698

COPB2
Coatomer subunit beta'

1

12

High-throughput

0.536

High

922091

COPA
Coatomer subunit alpha

1

12

High-throughput

0.536

High

1085490

SRBP2
Sterol regulatory element-binding protein 2

1

4

High-throughput

0.536

High

1325664

FGRL1
Fibroblast growth factor receptor-like 1

1

3

High-throughput

0.536

High

1372426

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

7

High-throughput

0.536

High

1380501

YIPF5
Protein YIPF5

1

5

High-throughput

0.536

High

1393854

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.536

High

1394819

CK5P3
CDK5 regulatory subunit-associated protein 3

1

5

High-throughput

0.536

High

1446124

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

4

High-throughput

0.536

High

1453856

VAPA
Vesicle-associated membrane protein-associated protein A

1

8

High-throughput

0.536

High

1450720

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

2

1

High-throughput

0.533

High

717365

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.521

High

389578

FINC
Fibronectin

1

0

High-throughput

0.513

High

890912

TSC2
Tuberin

1

0

High-throughput

0.513

High

963605

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

1381076

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.513

High

182848

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

215866

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

1

High-throughput

0.489

High

507004

POTEI
POTE ankyrin domain family member I

1

1

High-throughput

0.489

High

638264

S1PR1
Sphingosine 1-phosphate receptor 1

1

5

High-throughput

0.489

High

733099

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.489

High

1361379

BRI3B
BRI3-binding protein

1

2

High-throughput

0.489

High

1365028

TSC1
Hamartin

1

4

High-throughput

0.489

High

1410786

MBB1A
Myb-binding protein 1A

1

4

High-throughput

0.489

High

1432131

KLK15
Kallikrein-15

1

11

High-throughput

0.489

High

1435778

AT133
Polyamine-transporting ATPase 13A3

1

11

High-throughput

0.489

High

1458279

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.489

High

1460425

HERC5
E3 ISG15--protein ligase HERC5

1

3

High-throughput

0.489

High

1491124

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

133822

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

178448

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

218993

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

877579

LHX1
LIM/homeobox protein Lhx1

1

4

High-throughput

0.457

High

48848

ESYT2
Extended synaptotagmin-2

1

5

High-throughput

0.445

High

50736

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.445

High

60444

NBAS
NBAS subunit of NRZ tethering complex

1

2

High-throughput

0.445

High

104381

F5H6I7
Atlastin GTPase 3

1

8

High-throughput

0.445

High

211882

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.445

High

215683

EMC8
ER membrane protein complex subunit 8

1

2

High-throughput

0.445

High

275578

RTN2
Reticulon-2

1

8

High-throughput

0.445

High

283393

ERLN1
Erlin-1

1

2

High-throughput

0.445

High

296938

DGAT1
Diacylglycerol O-acyltransferase 1

1

1

High-throughput

0.445

High

329035

RTN3
Reticulon-3

1

8

High-throughput

0.445

High

333265

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

8

High-throughput

0.445

High

360151

NB5R3
NADH-cytochrome b5 reductase 3

1

2

High-throughput

0.445

High

437840

HEPS
Serine protease hepsin

1

2

High-throughput

0.445

High

535701

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.445

High

567117

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.445

High

698073

CALR
Calreticulin

1

10

High-throughput

0.445

High

873353

COPD
Coatomer subunit delta

1

3

High-throughput

0.445

High

903834

SSRD
Translocon-associated protein subunit delta

1

2

High-throughput

0.445

High

904213

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.445

High

921838

COPB
Coatomer subunit beta

1

3

High-throughput

0.445

High

964087

COPZ1
Coatomer subunit zeta-1

1

3

High-throughput

0.445

High

987277

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.445

High

1009912

NUCB2
Nucleobindin-2

1

2

High-throughput

0.445

High

1015160

ARF5
ADP-ribosylation factor 5

1

10

High-throughput

0.445

High

1027246

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.445

High

1097085

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.445

High

1098506

DNJC3
DnaJ homolog subfamily C member 3

1

3

High-throughput

0.445

High

1131436

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.445

High

1136421

EMC2
ER membrane protein complex subunit 2

1

4

High-throughput

0.445

High

1139305

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

2

High-throughput

0.445

High

1139423

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

2

High-throughput

0.445

High

1145724

RCN1
Reticulocalbin-1

1

4

High-throughput

0.445

High

1147879

DHC24
Delta(24)-sterol reductase

1

2

High-throughput

0.445

High

1152899

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

2

High-throughput

0.445

High

1199302

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

9

High-throughput

0.445

High

1248693

LCLT1
Lysocardiolipin acyltransferase 1

1

2

High-throughput

0.445

High

1316317

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

5

High-throughput

0.445

High

1328008

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

2

High-throughput

0.445

High

1334074

DHB11
Estradiol 17-beta-dehydrogenase 11

1

8

High-throughput

0.445

High

1337733

PDZD8
PDZ domain-containing protein 8

1

2

High-throughput

0.445

High

1340125

ATLA2
Atlastin-2

1

8

High-throughput

0.445

High

1340978

MCFD2
Multiple coagulation factor deficiency protein 2

1

2

High-throughput

0.445

High

1346840

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

12

High-throughput

0.445

High

1348093

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

4

High-throughput

0.445

High

1358405

SCFD1
Sec1 family domain-containing protein 1

1

2

High-throughput

0.445

High

1360592

ATLA1
Atlastin-1

1

8

High-throughput

0.445

High

1381554

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

10

High-throughput

0.445

High

1385792

RHDF1
Inactive rhomboid protein 1

1

1

High-throughput

0.445

High

1386243

ASTRA
Protein Aster-A

1

2

High-throughput

0.445

High

1396072

SCYL1
N-terminal kinase-like protein

1

5

High-throughput

0.445

High

1412173

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.445

High

1412733

ESYT1
Extended synaptotagmin-1

1

5

High-throughput

0.445

High

1419937

WDR11
WD repeat-containing protein 11

1

2

High-throughput

0.445

High

1421187

LNP
Endoplasmic reticulum junction formation protein lunapark

1

3

High-throughput

0.445

High

1432084

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

2

High-throughput

0.445

High

1432783

TMX1
Thioredoxin-related transmembrane protein 1

1

8

High-throughput

0.445

High

1446948

RTN4
Reticulon-4

1

8

High-throughput

0.445

High

1449589

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.445

High

1450862

TM38B
Trimeric intracellular cation channel type B

1

2

High-throughput

0.445

High

1452926

TECR
Very-long-chain enoyl-CoA reductase

1

4

High-throughput

0.445

High

1458359

COPG2
Coatomer subunit gamma-2

1

7

High-throughput

0.445

High

1490712

DJC16
DnaJ homolog subfamily C member 16

1

10

High-throughput

0.445

High

1491082

DHRS7
Dehydrogenase/reductase SDR family member 7

1

5

High-throughput

0.445

High

1491126

COPG1
Coatomer subunit gamma-1

1

7

High-throughput

0.445

High

1135516

T132D
Transmembrane protein 132D

1

1

Small-scale

0.439

High

223439

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.437

High

316197

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

769581

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

879650

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

947321

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

9

High-throughput

0.437

High

1229782

VIR
Protein virilizer homolog

1

4

High-throughput

0.437

High

1348590

LNX1
E3 ubiquitin-protein ligase LNX

1

4

Small-scale

0.437

High

1162163

MA2A1
Alpha-mannosidase 2

1

0

High-throughput

0.426

High

1259094

ILDR2
Immunoglobulin-like domain-containing receptor 2

1

0

High-throughput

0.426

High

1349195

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.426

High

1462674

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.426

High

1397200

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

6

Small-scale

0.417

High

213666

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

2

High-throughput

0.407

High

256202

S19A2
Thiamine transporter 1

1

4

High-throughput

0.407

High

296593

STAM2
Signal transducing adapter molecule 2

1

4

High-throughput

0.407

High

319038

MICA2
[F-actin]-monooxygenase MICAL2

1

2

High-throughput

0.407

High

351265

MOT3
Monocarboxylate transporter 3

1

2

High-throughput

0.407

High

462723

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

High-throughput

0.407

High

530638

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.407

High

877048

KC1A
Casein kinase I isoform alpha

1

4

High-throughput

0.407

High

883167

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

2

High-throughput

0.407

High

1236387

MFSD5
Molybdate-anion transporter

1

7

High-throughput

0.407

High

1242278

NPAL3
NIPA-like protein 3

1

8

High-throughput

0.407

High

1258834

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

3

High-throughput

0.407

High

1273833

NIPA1
Magnesium transporter NIPA1

1

8

High-throughput

0.407

High

1313886

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

1336051

CTL5
Choline transporter-like protein 5

1

1

High-throughput

0.407

High

1338239

VP37A
Vacuolar protein sorting-associated protein 37A

1

2

High-throughput

0.407

High

1401912

NUDC1
NudC domain-containing protein 1

1

2

High-throughput

0.407

High

1412010

PXL2A
Peroxiredoxin-like 2A

1

2

High-throughput

0.407

High

1413802

NDC1
Nucleoporin NDC1

1

2

High-throughput

0.407

High

1430102

RGAP1
Rac GTPase-activating protein 1

1

2

High-throughput

0.407

High

1438261

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.407

High

1438692

NCKX3
Sodium/potassium/calcium exchanger 3

1

1

High-throughput

0.407

High

1439752

APMAP
Adipocyte plasma membrane-associated protein

1

2

High-throughput

0.407

High

1446383

IL1AP
Interleukin-1 receptor accessory protein

1

4

High-throughput

0.407

High

1446656

AT132
Polyamine-transporting ATPase 13A2

1

12

High-throughput

0.407

High

1451106

GPTC2
G patch domain-containing protein 2

1

2

High-throughput

0.407

High

1452620

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.407

High

1491125

SERC
Phosphoserine aminotransferase

1

2

High-throughput

0.407

High

1059113

CXCL9
C-X-C motif chemokine 9

2

0

High-throughput

0.316

High

1396947

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.299

High

749305

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

1396279

ASPP1
Apoptosis-stimulating of p53 protein 1

1

0

High-throughput

0.279

Low

64924

PLHD1
Pleckstrin homology domain-containing family D member 1

1

0

High-throughput

0.249

Low

837372

ECI1
Enoyl-CoA delta isomerase 1, mitochondrial

1

0

High-throughput

0.249

Low

1460587

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.249

Low

1462610

UN13A
Protein unc-13 homolog A

1

0

High-throughput

0.249

Low

132931

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.232

Low

1232152

VASN
Vasorin

1

0

High-throughput

0.232

Low

1242447

WDR73
Integrator complex assembly factor WDR73

1

0

High-throughput

0.232

Low

1249485

DHR13
Dehydrogenase/reductase SDR family member 13

1

0

High-throughput

0.232

Low

1292250

LONP2
Lon protease homolog 2, peroxisomal

1

0

High-throughput

0.232

Low

1322171

CENPL
Centromere protein L

1

0

High-throughput

0.232

Low

1329333

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.232

Low

1331324

S2529
Mitochondrial basic amino acids transporter

1

0

High-throughput

0.232

Low

1357348

THEM6
Protein THEM6

1

0

High-throughput

0.232

Low

1413259

SYT11
Synaptotagmin-11

1

0

High-throughput

0.232

Low

1451605

TM160
Transmembrane protein 160

1

0

High-throughput

0.232

Low

1453714

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.232

Low

1459190

S23A2
Solute carrier family 23 member 2

1

0

High-throughput

0.232

Low

1491127

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.232

Low

1491128

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025