Protein: HFI1
SAGA complex subunit HFI1 (General activator of nitrogen pathway genes protein 1) (Transcriptional coactivator HFI1/ADA1)

Gene: HFI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 158
UniProt ID: Q12060

Gene Ontology (top 5):
GO:0000124 - SAGA complex
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794013

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

13

1

Small-scale

0.977

High

916614

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

12

1

Small-scale

0.977

High

1043987

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

12

1

Small-scale

0.974

High

1050243

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

9

1

Small-scale

0.965

High

898200

SPT20
SAGA complex subunit SPT20

14

0

Small-scale

0.933

High

763041

SPT7
SAGA complex subunit SPT7

20

3

Small-scale

0.764

High

1036355

ADA2
SAGA complex subunit ADA2

14

2

Small-scale

0.762

High

1042397

GCN5
Histone acetyltransferase GCN5

13

1

Small-scale

0.759

High

805234

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

13

2

Small-scale

0.758

High

449475

SPT3
SAGA complex subunit SPT3

12

1

Small-scale

0.757

High

738185

NGG1
SAGA complex subunit NGG1

11

1

Small-scale

0.754

High

893352

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

11

1

Small-scale

0.754

High

807285

SPT8
SAGA complex subunit SPT8

9

1

Small-scale

0.753

High

676683

SGF29
SAGA complex subunit SGF29

7

1

Small-scale

0.746

High

917876

SGF73
SAGA complex subunit SGF73

8

1

Small-scale

0.745

High

1084146

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

7

1

Small-scale

0.742

High

1040682

SGF11
SAGA complex subunit SGF11

7

0

Small-scale

0.710

High

1084212

SUS1
SAGA complex subunit SUS1

4

1

Small-scale

0.694

High

525469

HSP71
Heat shock protein SSA1

3

2

Small-scale

0.624

High

561545

TBP
TATA-box-binding protein

2

0

Small-scale

0.585

High

1084207

HFI1
SAGA complex subunit HFI1

2

0

Small-scale

0.585

High

734491

BTAF1
TATA-binding protein-associated factor MOT1

2

1

Small-scale

0.584

High

626545

AP1
AP-1-like transcription factor YAP1

2

0

High-throughput

0.576

High

527959

HSP72
Heat shock protein SSA2

2

2

Small-scale

0.571

High

820064

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

Small-scale

0.571

High

1084208

YRA1
RNA annealing protein YRA1

2

0

Small-scale

0.559

High

754257

MSN4
Zinc finger protein MSN4

2

1

High-throughput

0.552

High

792302

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.546

High

481804

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.536

High

466807

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.513

High

722339

XPO1
Exportin-1

1

0

High-throughput

0.513

High

733564

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.513

High

917290

MED5
Mediator of RNA polymerase II transcription subunit 5

1

0

High-throughput

0.513

High

1053175

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.513

High

1084209

HAL9
Halotolerance protein 9

1

0

High-throughput

0.513

High

470162

SPS1
Sporulation-specific protein 1

1

0

High-throughput

0.493

High

735578

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.480

High

740626

IME2
Meiosis induction protein kinase IME2/SME1

1

0

High-throughput

0.480

High

359370

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

Small-scale

0.479

High

546658

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

Small-scale

0.479

High

793461

ATR
Serine/threonine-protein kinase MEC1

1

2

Small-scale

0.479

High

800777

RCK1
Serine/threonine-protein kinase RCK1

1

1

High-throughput

0.479

High

435427

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

439448

PDC1
Pyruvate decarboxylase isozyme 1

1

0

Small-scale

0.458

High

486795

CDC16
Anaphase-promoting complex subunit CDC16

1

0

Small-scale

0.458

High

708472

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

736749

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

737967

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

741171

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

744357

CHD1
Chromo domain-containing protein 1

1

0

Small-scale

0.458

High

764027

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

764173

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

808931

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

813680

DHE5
NADP-specific glutamate dehydrogenase 2

1

0

Small-scale

0.458

High

864047

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.458

High

865776

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

1043906

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.458

High

1046551

LCD1
DNA damage checkpoint protein LCD1

1

0

Small-scale

0.458

High

359083

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.445

High

692642

NSR1
Nuclear localization sequence-binding protein

1

1

High-throughput

0.445

High

742626

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

754194

MSN2
Zinc finger protein MSN2

1

1

High-throughput

0.445

High

804543

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

850597

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.445

High

811248

PCF11
Protein PCF11

1

0

High-throughput

0.438

High

452986

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

511970

RS30A
Small ribosomal subunit protein eS30A

1

1

High-throughput

0.437

High

592563

VATB
V-type proton ATPase subunit B

1

1

Small-scale

0.437

High

402245

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.426

High

448238

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

452762

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.426

High

534075

HSF
Heat shock transcription factor

1

0

High-throughput

0.426

High

584944

TRM1
tRNA

1

0

High-throughput

0.426

High

590747

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

597297

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

670353

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.426

High

674435

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.426

High

694257

BUD14
Bud site selection protein 14

1

0

High-throughput

0.426

High

694666

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

918851

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.426

High

1027379

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.426

High

1059473

SUB2
ATP-dependent RNA helicase SUB2

1

0

High-throughput

0.426

High

1084210

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

359540

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.407

High

383205

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.407

High

427760

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.407

High

445378

CDC31
Cell division control protein 31

1

1

High-throughput

0.407

High

511992

RS30B
Small ribosomal subunit protein eS30B

1

1

High-throughput

0.407

High

575622

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

1

High-throughput

0.407

High

603567

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.407

High

656357

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

1

High-throughput

0.407

High

737787

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.407

High

358370

ADH1
Alcohol dehydrogenase 1

2

0

Small-scale

0.298

High

626918

HSP60
Heat shock protein 60, mitochondrial

2

0

Small-scale

0.298

High

734229

EF2
Elongation factor 2

2

0

Small-scale

0.298

High

639458

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.279

Low

738440

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.279

Low

781275

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.279

Low

1043607

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

1057083

MRL1
Mannose 6-phosphate receptor-like protein 1

1

0

High-throughput

0.279

Low

1065616

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.269

Low

150000

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

365219

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.249

Low

365709

PGK
Phosphoglycerate kinase

1

0

Small-scale

0.249

Low

367412

CISY1
Citrate synthase, mitochondrial

1

0

Small-scale

0.249

Low

368081

ENO2
Enolase 2

1

0

Small-scale

0.249

Low

383939

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

394995

EF1A
Elongation factor 1-alpha

1

0

Small-scale

0.249

Low

433895

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

436222

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

442162

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

503295

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504463

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

513276

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

513789

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

689715

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

705797

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

0

Small-scale

0.249

Low

747628

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

753643

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778582

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

802438

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

805368

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

Small-scale

0.249

Low

820511

RGI2
Respiratory growth induced protein 2

1

0

High-throughput

0.249

Low

830098

FET4
Low-affinity Fe(2+) transport protein

1

0

Small-scale

0.249

Low

1033622

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1062754

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

Small-scale

0.249

Low

1064819

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

386905

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

417193

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.232

Low

427478

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

427618

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.232

Low

439172

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.232

Low

449194

CALM
Calmodulin

1

0

High-throughput

0.232

Low

502757

RS21A
Small ribosomal subunit protein eS21A

1

0

High-throughput

0.232

Low

510895

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

518419

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.232

Low

569879

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

572665

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.232

Low

580219

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

597577

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

599090

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.232

Low

609248

CLC1
Clathrin light chain

1

0

High-throughput

0.232

Low

632927

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.232

Low

672357

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.232

Low

692448

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.232

Low

700205

GAC1
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

1

0

High-throughput

0.232

Low

760634

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.232

Low

811064

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low

820363

YNU8
Uncharacterized protein YNL208W

1

0

High-throughput

0.232

Low

919274

YG3A
Uncharacterized protein YGR130C

1

0

High-throughput

0.232

Low

924302

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.232

Low

924516

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

1033460

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.232

Low

1039655

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.232

Low

1059340

YD073
UPF0592 protein YDL073W

1

0

High-throughput

0.232

Low

1062790

BRX1
Ribosome biogenesis protein BRX1

1

0

High-throughput

0.232

Low

1084211

NOP58
Nucleolar protein 58

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025