Protein: AMPL
Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I)

Gene: AMPL, APE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 97
UniProt ID: P14904

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0005737 - cytoplasm
GO:0006508 - proteolysis
GO:0008270 - zinc ion binding
GO:0032258 - cytoplasm to vacuole targeting by the Cvt pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

576926

AMPL
Vacuolar aminopeptidase 1

8

4

Small-scale

0.972

High

576965

DNPEP
Aspartyl aminopeptidase 4

2

4

High-throughput

0.775

High

576960

ATG19
Autophagy-related protein 19

18

2

Small-scale

0.766

High

576963

ATG8
Autophagy-related protein 8

5

2

Small-scale

0.704

High

576940

MAN1
Alpha-mannosidase

3

0

High-throughput

0.636

High

577003

ATG11
Autophagy-related protein 11

3

0

Small-scale

0.626

High

576942

MXR2
Peptide methionine sulfoxide reductase 2

2

0

Small-scale

0.600

High

576981

ATG1
Serine/threonine-protein kinase ATG1

2

0

Small-scale

0.569

High

577000

ATG9
Autophagy-related protein 9

2

0

Small-scale

0.569

High

576947

BMH1
Protein BMH1

2

0

High-throughput

0.569

High

576954

TFB1
General transcription and DNA repair factor IIH subunit TFB1

2

1

High-throughput

0.566

High

576927

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.559

High

576988

IMA1
Importin subunit alpha

1

1

High-throughput

0.541

High

543680

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

576934

PHO80
PHO85 cyclin PHO80

1

1

High-throughput

0.536

High

576967

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.536

High

576972

PCL6
PHO85 cyclin-6

1

1

High-throughput

0.536

High

575881

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.513

High

576931

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

0

High-throughput

0.513

High

576946

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

576948

XPO1
Exportin-1

1

0

High-throughput

0.513

High

576971

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.513

High

576980

MRK1
Serine/threonine-protein kinase MRK1

1

0

High-throughput

0.513

High

576998

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.513

High

576983

AF9
Protein AF-9 homolog

1

1

High-throughput

0.508

High

577001

ATG34
Autophagy-related protein 34

1

2

Small-scale

0.501

High

576966

TEM1
Protein TEM1

1

3

High-throughput

0.494

High

576968

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.486

High

576975

SEC24
Protein transport protein SEC24

1

0

High-throughput

0.486

High

576991

TR130
Trafficking protein particle complex II-specific subunit 130

1

0

High-throughput

0.486

High

576995

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.480

High

367672

ENO1
Enolase 1

1

0

High-throughput

0.479

High

432281

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

439220

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

572499

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

576928

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

576970

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.479

High

576990

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.479

High

576957

YPT7
Ypt/Rab-type GTPase YPT7

1

1

High-throughput

0.479

High

577004

YPT6
GTP-binding protein YPT6

1

2

High-throughput

0.479

High

576951

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.464

High

571338

CPYI
Carboxypeptidase Y inhibitor

1

0

Small-scale

0.458

High

576935

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.458

High

576938

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

576939

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

576945

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

576950

SP110
Spindle pole body component 110

1

0

High-throughput

0.458

High

576956

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

576969

SS120
Protein SSP120

1

0

High-throughput

0.458

High

576974

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

576987

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

576992

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.458

High

576999

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

577002

NAA25
N-terminal acetyltransferase B complex subunit MDM20

1

0

High-throughput

0.458

High

368574

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

405012

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

538317

PYC1
Pyruvate carboxylase 1

1

1

High-throughput

0.457

High

576930

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.457

High

576949

PYC2
Pyruvate carboxylase 2

1

1

High-throughput

0.457

High

522928

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

576953

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

576973

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

576943

CDC48
Cell division control protein 48

1

1

High-throughput

0.437

High

576989

TRS31
Trafficking protein particle complex subunit 31

1

1

High-throughput

0.437

High

576929

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

576976

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

576984

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.426

High

576997

ADY3
Accumulates dyads protein 3

2

0

High-throughput

0.323

High

380944

H2B1
Histone H2B.1

1

0

High-throughput

0.279

Low

548171

BIK1
Nuclear fusion protein BIK1

1

0

High-throughput

0.279

Low

576937

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.279

Low

576959

CLG1
PHO85 cyclin CLG1

1

0

High-throughput

0.279

Low

576977

MIL1
Probable lipase MIL1

1

0

High-throughput

0.279

Low

576985

H3
Histone H3

1

0

High-throughput

0.279

Low

576944

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

High-throughput

0.265

Low

576962

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.265

Low

576986

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.265

Low

576996

SWC7
SWR1-complex protein 7

1

0

High-throughput

0.265

Low

425101

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

439075

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

576932

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

576936

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

448882

TYSY
Thymidylate synthase

1

0

High-throughput

0.249

Low

554391

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

Small-scale

0.249

Low

576941

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

576952

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.249

Low

576955

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

576958

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.249

Low

576961

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

576964

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.249

Low

576978

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

576979

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

576982

MTM1
Mitochondrial carrier protein MTM1

1

0

High-throughput

0.249

Low

576993

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

576994

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

576933

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025