Protein: RRP43
Exosome complex component RRP43 (Ribosomal RNA-processing protein 43)

Gene: RRP43
Organism: Saccharomyces cerevisiae S288C
Interactions: 164
UniProt ID: P25359

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 - nuclear-transcribed mRNA catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

672966

RRP44
Exosome complex exonuclease DIS3

12

1

Small-scale

0.981

High

672919

RRP46
Exosome complex component RRP46

12

2

Small-scale

0.980

High

672908

RRP41
Exosome complex component SKI6

9

2

Small-scale

0.970

High

672947

RRP45
Exosome complex component RRP45

8

2

Small-scale

0.967

High

672927

CSL4
Exosome complex component CSL4

10

0

Small-scale

0.923

High

672883

RRP4
Exosome complex component RRP4

6

0

Small-scale

0.895

High

672913

MTR3
Exosome complex component MTR3

5

0

Small-scale

0.872

High

672969

RRP40
Exosome complex component RRP40

3

0

High-throughput

0.803

High

672979

RRP6
Exosome complex exonuclease RRP6

12

0

Small-scale

0.724

High

672984

RRP42
Exosome complex component RRP42

5

2

Small-scale

0.712

High

672972

SKI7
Superkiller protein 7

7

0

Small-scale

0.712

High

672925

MPP6
M-phase phosphoprotein 6 homolog

4

0

Small-scale

0.662

High

672974

NIP7
60S ribosome subunit biogenesis protein NIP7

3

0

Small-scale

0.648

High

672884

LRP1
Exosome complex protein LRP1

4

0

Small-scale

0.648

High

664248

SSD1
Protein SSD1

1

1

High-throughput

0.618

High

672855

KRR1
KRR1 small subunit processome component

3

0

High-throughput

0.613

High

672880

ENP1
Essential nuclear protein 1

3

0

High-throughput

0.613

High

672903

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

672940

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.613

High

672945

RRP5
rRNA biogenesis protein RRP5

3

0

High-throughput

0.606

High

672869

SKI2
Antiviral helicase SKI2

2

3

High-throughput

0.601

High

672909

MTR4
ATP-dependent RNA helicase DOB1

2

3

High-throughput

0.601

High

672935

IMA1
Importin subunit alpha

2

0

High-throughput

0.595

High

672850

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.586

High

672907

ROK1
ATP-dependent RNA helicase ROK1

2

2

High-throughput

0.584

High

672957

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

672986

DBP10
ATP-dependent RNA helicase DBP10

2

1

High-throughput

0.584

High

609038

SKI3
Superkiller protein 3

2

0

High-throughput

0.559

High

672886

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.559

High

672918

UTP22
U3 small nucleolar RNA-associated protein 22

2

0

High-throughput

0.559

High

672928

NOP13
Nucleolar protein 13

2

0

High-throughput

0.559

High

672929

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.559

High

672943

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

672975

BMS1
Ribosome biogenesis protein BMS1

2

0

High-throughput

0.559

High

672978

SAS10
Something about silencing protein 10

2

0

High-throughput

0.559

High

672990

NOP14
Nucleolar complex protein 14

2

0

High-throughput

0.559

High

672881

PIH1
Protein interacting with Hsp90 1

1

0

Small-scale

0.549

High

672885

BZZ1
Protein BZZ1

1

0

High-throughput

0.518

High

672923

NRD1
Protein NRD1

1

0

Small-scale

0.513

High

672865

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.493

High

672871

MYO3
Myosin-3

1

0

High-throughput

0.493

High

672917

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.493

High

672924

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.493

High

672878

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.480

High

672977

NOP53
Ribosome biogenesis protein NOP53

1

0

Small-scale

0.480

High

584182

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

4

High-throughput

0.479

High

632529

DBP3
ATP-dependent RNA helicase DBP3

1

1

High-throughput

0.479

High

632621

DBP4
ATP-dependent RNA helicase HCA4

1

2

High-throughput

0.479

High

666395

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

672856

PWP2
Periodic tryptophan protein 2

1

1

High-throughput

0.479

High

672860

RENT1
ATP-dependent helicase NAM7

1

1

High-throughput

0.479

High

672879

MAK5
ATP-dependent RNA helicase MAK5

1

2

High-throughput

0.479

High

672915

CLA4
Serine/threonine-protein kinase CLA4

1

1

High-throughput

0.479

High

672921

ASCC3
RQC trigger complex helicase SLH1

1

2

High-throughput

0.479

High

672926

DBP6
ATP-dependent RNA helicase DBP6

1

3

High-throughput

0.479

High

672930

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

672931

SEN1
Helicase SEN1

1

1

High-throughput

0.479

High

672934

SKI8
Antiviral protein SKI8

1

2

High-throughput

0.479

High

672937

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

672938

HAS1
ATP-dependent RNA helicase HAS1

1

3

High-throughput

0.479

High

672939

UTP5
U3 small nucleolar RNA-associated protein 5

1

1

High-throughput

0.479

High

672946

FCF1
rRNA-processing protein FCF1

1

1

High-throughput

0.479

High

672948

UTP13
U3 small nucleolar RNA-associated protein 13

1

2

High-throughput

0.479

High

672949

UTP21
U3 small nucleolar RNA-associated protein 21

1

2

High-throughput

0.479

High

672951

JIP5
WD repeat-containing protein JIP5

1

1

High-throughput

0.479

High

672952

DBP9
ATP-dependent RNA helicase DBP9

1

1

High-throughput

0.479

High

672959

UTP4
U3 small nucleolar RNA-associated protein 4

1

1

High-throughput

0.479

High

672962

NOC3
Nucleolar complex-associated protein 3

1

1

High-throughput

0.479

High

672967

BRX1
Ribosome biogenesis protein BRX1

1

2

High-throughput

0.479

High

672981

MAK21
Ribosome biogenesis protein MAK21

1

2

High-throughput

0.479

High

672982

UTP12
U3 small nucleolar RNA-associated protein 12

1

2

High-throughput

0.479

High

672985

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.479

High

672987

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

672988

NOP58
Nucleolar protein 58

1

1

High-throughput

0.479

High

436330

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

438804

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.458

High

448647

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.458

High

517910

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.458

High

534082

MAK16
Protein MAK16

1

0

High-throughput

0.458

High

597710

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.458

High

636544

PSA7
Probable proteasome subunit alpha type-7

1

0

High-throughput

0.458

High

637172

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.458

High

653823

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.458

High

672851

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

672853

GBP2
Serine/arginine

1

0

High-throughput

0.458

High

672854

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.458

High

672857

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.458

High

672858

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.458

High

672859

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

672864

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

672866

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.458

High

672867

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

672868

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

672870

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

672872

EBP2
rRNA-processing protein EBP2

1

0

High-throughput

0.458

High

672873

YKH5
Uncharacterized protein YKL075C

1

0

High-throughput

0.458

High

672874

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.458

High

672875

RQT4
RQC trigger complex subunit RQT4

1

0

High-throughput

0.458

High

672876

YC16
UPF0743 protein YCR087C-A

1

0

High-throughput

0.458

High

672877

NOP4
Nucleolar protein 4

1

0

High-throughput

0.458

High

672882

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.458

High

672887

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.458

High

672888

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

672889

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.458

High

672890

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.458

High

672891

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.458

High

672892

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.458

High

672893

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

672894

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

672896

RIO2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.458

High

672897

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

672898

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

672899

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

672901

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

672902

KRI1
Protein KRI1

1

0

High-throughput

0.458

High

672904

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.458

High

672905

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

672906

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.458

High

672911

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

High-throughput

0.458

High

672912

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

672914

UPF3
Nonsense-mediated mRNA decay protein 3

1

0

High-throughput

0.458

High

672920

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

672922

H1
Histone H1

1

0

High-throughput

0.458

High

672932

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

672933

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

672936

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.458

High

672941

UTP15
U3 small nucleolar RNA-associated protein 15

1

0

High-throughput

0.458

High

672942

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.458

High

672950

MRD1
Multiple RNA-binding domain-containing protein 1

1

0

High-throughput

0.458

High

672953

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

672954

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

672955

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.458

High

672956

RRP9
Ribosomal RNA-processing protein 9

1

0

High-throughput

0.458

High

672958

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

672960

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

672961

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

672963

RLP24
Ribosome biogenesis protein RLP24

1

0

High-throughput

0.458

High

672964

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

0

High-throughput

0.458

High

672965

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

672970

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

672971

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.458

High

672973

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

672976

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

672980

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

672983

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.458

High

672989

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

523162

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526011

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

543933

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

672861

HSP79
Heat shock protein homolog SSE2

1

2

High-throughput

0.445

High

672895

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

392289

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

672852

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

672863

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

672910

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

420887

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.249

Low

433469

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

672862

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.249

Low

672900

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.249

Low

672916

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.249

Low

672944

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.249

Low

672968

ZEO1
Protein ZEO1

1

0

High-throughput

0.249

Low

554667

YPK1
Serine/threonine-protein kinase YPK1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025