Protein: APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1 (Ap4A phosphorylase 1) (EC 2.7.7.53) (ADP-sulfurylase) (EC 2.7.7.5) (ATP adenylyltransferase) (Diadenosine tetraphosphate alpha,beta-phosphorylase (ADP-forming))]

Gene: APA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 100
UniProt ID: P16550

Gene Ontology (top 5):
GO:0003877 - ATP:ADP adenylyltransferase activity
GO:0004780 - sulfate adenylyltransferase (ADP) activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

578780

HSC82
ATP-dependent molecular chaperone HSC82

4

2

High-throughput

0.666

High

525839

HSP72
Heat shock protein SSA2

3

1

High-throughput

0.624

High

392172

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.571

High

522959

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.571

High

597745

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

364907

KPYK1
Pyruvate kinase 1

2

0

High-throughput

0.547

High

359423

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

2

2

High-throughput

0.521

High

597747

LSM8
LSM2-LSM8 complex subunit LSM8

1

0

High-throughput

0.513

High

597751

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

597703

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

358959

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

359140

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

597709

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

597714

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

597719

ZUO1
Zuotin

1

1

Small-scale

0.479

High

597756

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

597763

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

2

High-throughput

0.479

High

597767

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

597754

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.460

High

464543

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

597710

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

597712

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

597717

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

597718

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

597721

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

597726

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

597733

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

597734

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

597738

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

597749

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

597752

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

Small-scale

0.458

High

597757

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

597759

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

597764

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

597765

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

597766

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

597768

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

366912

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.445

High

470451

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

543713

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

591985

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

597378

EF3A
Elongation factor 3A

1

2

High-throughput

0.445

High

597704

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.445

High

597708

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.445

High

597739

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

597744

GCN20
Protein GCN20

1

1

High-throughput

0.445

High

597753

ACAC
Acetyl-CoA carboxylase

1

1

High-throughput

0.445

High

358107

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

381848

H4
Histone H4

1

0

High-throughput

0.426

High

386553

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394196

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

416191

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

434792

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.426

High

439225

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.426

High

450516

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

452558

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.426

High

453405

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

471370

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.426

High

481851

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

486010

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

531232

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.426

High

569709

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.426

High

597702

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.426

High

597705

UPP
Uracil phosphoribosyltransferase

1

0

High-throughput

0.426

High

597713

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

597720

RPN2
26S proteasome regulatory subunit RPN2

1

0

High-throughput

0.426

High

597723

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.426

High

597727

NDK
Nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

597729

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.426

High

597730

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.426

High

597731

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

High-throughput

0.426

High

597735

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.426

High

597737

IMB4
Importin subunit beta-4

1

0

High-throughput

0.426

High

597743

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

597746

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

597748

MSN5
Protein MSN5

1

0

High-throughput

0.426

High

597755

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.426

High

597758

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

597760

TRM3
tRNA

1

0

High-throughput

0.426

High

597762

MDN1
Midasin

1

0

High-throughput

0.426

High

597725

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.407

High

597742

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.407

High

597750

COPA
Coatomer subunit alpha

1

1

High-throughput

0.407

High

368579

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.249

Low

597732

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

597740

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

439079

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.232

Low

455474

PMM
Phosphomannomutase

1

0

High-throughput

0.232

Low

575374

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

597706

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.232

Low

597707

SAR1
Small COPII coat GTPase SAR1

1

0

High-throughput

0.232

Low

597711

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.232

Low

597715

COPG
Coatomer subunit gamma

1

0

High-throughput

0.232

Low

597716

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

597722

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

597724

CSE1
Importin alpha re-exporter

1

0

High-throughput

0.232

Low

597728

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

597736

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.232

Low

597741

COPB
Coatomer subunit beta

1

0

High-throughput

0.232

Low

597761

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025