Protein: FDFT
Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1)

Gene: FDFT, FDFT1
Organism: Homo sapiens
Interactions: 158
UniProt ID: P37268

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006694 - steroid biosynthetic process
GO:0006695 - cholesterol biosynthetic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

789958

UN93B
Protein unc-93 homolog B1

4

0

High-throughput

0.667

High

789916

ST32C
Serine/threonine-protein kinase 32C

3

0

High-throughput

0.638

High

789876

AGRE5
Adhesion G protein-coupled receptor E5

2

1

High-throughput

0.628

High

789915

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

2

High-throughput

0.611

High

789953

P2RX4
P2X purinoceptor 4

2

1

High-throughput

0.611

High

789957

ELOV4
Very long chain fatty acid elongase 4

2

1

High-throughput

0.606

High

789976

POMT2
Protein O-mannosyl-transferase 2

2

0

High-throughput

0.602

High

789981

SRPRB
Signal recognition particle receptor subunit beta

2

0

High-throughput

0.585

High

284386

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

2

0

High-throughput

0.580

High

407047

HG2A
HLA class II histocompatibility antigen gamma chain

2

0

High-throughput

0.580

High

789909

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.580

High

789927

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

789948

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

789950

PANX1
Pannexin-1

2

0

High-throughput

0.580

High

789979

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

789879

P2RX1
P2X purinoceptor 1

2

1

High-throughput

0.574

High

789885

RHOA
Transforming protein RhoA

2

1

High-throughput

0.571

High

789887

RAC1
Ras-related C3 botulinum toxin substrate 1

2

1

High-throughput

0.571

High

789975

S12A6
Solute carrier family 12 member 6

2

1

Small-scale

0.571

High

789884

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

789892

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

789933

GP152
Probable G-protein coupled receptor 152

2

4

High-throughput

0.553

High

789870

GLP1R
Glucagon-like peptide 1 receptor

1

2

Small-scale

0.552

High

771096

APJ
Apelin receptor

2

1

High-throughput

0.549

High

230274

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.549

High

789977

RUVB2
RuvB-like 2

1

1

High-throughput

0.541

High

182482

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

762105

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

789943

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.536

High

476105

ANXA5
Annexin A5

1

0

High-throughput

0.518

High

612044

ITB5
Integrin beta-5

1

0

High-throughput

0.518

High

789897

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.518

High

789954

TMM43
Transmembrane protein 43

1

0

High-throughput

0.518

High

789978

RUVB1
RuvB-like 1

1

1

High-throughput

0.515

High

374441

RASH
GTPase HRas

1

0

High-throughput

0.513

High

607909

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.513

High

789871

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.513

High

789924

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

789935

TS1R2
Taste receptor type 1 member 2

1

0

High-throughput

0.513

High

789945

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

789956

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

789961

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

789896

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

1

High-throughput

0.494

High

220744

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.493

High

789881

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

789940

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.493

High

165912

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

640369

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.489

High

732958

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

2

High-throughput

0.489

High

789891

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

789964

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.489

High

789982

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

403880

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

789893

CUL3
Cullin-3

1

1

High-throughput

0.479

High

789918

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

789928

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

789960

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

164274

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

173874

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

240938

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

258788

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

342774

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

362891

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

417290

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

417982

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

536639

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

543075

UBL4A
Ubiquitin-like protein 4A

1

0

High-throughput

0.458

High

552519

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

713904

PML
Protein PML

1

0

High-throughput

0.458

High

789872

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

789878

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

789898

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

789904

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.458

High

789911

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

789919

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

789925

PNKD
Probable thioesterase PNKD

1

0

High-throughput

0.458

High

789934

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

789938

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

789952

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

789955

DERL1
Derlin-1

1

0

High-throughput

0.458

High

789963

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

789966

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

789973

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

789873

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.445

High

789874

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

1

High-throughput

0.445

High

789913

SV2B
Synaptic vesicle glycoprotein 2B

1

1

High-throughput

0.445

High

789894

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

789939

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

Small-scale

0.437

High

789942

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

789980

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

High-throughput

0.437

High

248845

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

722408

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.426

High

789882

SC5A3
Sodium/myo-inositol cotransporter

1

0

High-throughput

0.426

High

789883

CD81
CD81 antigen

1

0

High-throughput

0.426

High

789889

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.426

High

789921

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.426

High

789932

F174A
Membrane protein FAM174A

1

0

High-throughput

0.426

High

789959

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.426

High

789908

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

789910

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.407

High

789920

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

789926

SVOP
Synaptic vesicle 2-related protein

1

2

High-throughput

0.407

High

789941

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.407

High

789929

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

2

0

High-throughput

0.328

High

789968

CNNM1
Metal transporter CNNM1

2

0

High-throughput

0.328

High

549739

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

789875

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.316

High

789895

NTCP
Hepatic sodium/bile acid cotransporter

2

0

High-throughput

0.316

High

789903

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

789905

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

789965

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

281187

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.279

Low

342520

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

389105

FINC
Fibronectin

1

0

High-throughput

0.279

Low

469464

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

700775

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.279

Low

789890

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.279

Low

789899

PDK3
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

789902

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

789914

BOP
Protein Bop

1

0

High-throughput

0.279

Low

789931

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

789944

HDA10
Polyamine deacetylase HDAC10

1

0

High-throughput

0.279

Low

789949

OPALI
Opalin

1

0

High-throughput

0.279

Low

298490

SPF30
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.269

Low

789936

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.269

Low

385514

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

217907

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

293310

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

324604

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

588071

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

694786

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

714725

KAIN
Kallistatin

1

0

High-throughput

0.249

Low

767566

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

789869

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

789877

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

789886

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

789888

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

789901

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.249

Low

789906

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

789907

FYB2
FYN-binding protein 2

1

0

High-throughput

0.249

Low

789912

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

789922

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

789930

DNJB8
DnaJ homolog subfamily B member 8

1

0

High-throughput

0.249

Low

789937

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

789946

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

789947

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

789951

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

789962

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

789967

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

789969

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

789970

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

789971

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

789972

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

789974

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

789880

GPC3
Glypican-3

1

0

High-throughput

0.232

Low

789900

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.232

Low

789917

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

789923

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025