Protein: CK5P3
CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)

Gene: CK5P3, CDK5RAP3
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q96JB5

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001889 - liver development
GO:0001933 - negative regulation of protein phosphorylation
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

319983

UFL1
E3 UFM1-protein ligase 1

10

2

Small-scale

0.978

High

1393599

DDRGK
DDRGK domain-containing protein 1

8

2

Small-scale

0.963

High

964549

UFM1
Ubiquitin-fold modifier 1

3

0

Small-scale

0.776

High

276712

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

5

1

High-throughput

0.726

High

1394824

SRPRB
Signal recognition particle receptor subunit beta

5

0

High-throughput

0.681

High

1394820

UFC1
Ubiquitin-fold modifier-conjugating enzyme 1

4

0

Small-scale

0.667

High

1105866

TMED1
Transmembrane emp24 domain-containing protein 1

3

5

High-throughput

0.662

High

1394813

TSYL4
Testis-specific Y-encoded-like protein 4

3

0

High-throughput

0.646

High

168886

PLD2
Phospholipase D2

3

0

High-throughput

0.634

High

842832

CDN2A
Cyclin-dependent kinase inhibitor 2A

3

0

Small-scale

0.633

High

1394808

PD1L1
Programmed cell death 1 ligand 1

4

1

High-throughput

0.630

High

888959

TMEDA
Transmembrane emp24 domain-containing protein 10

2

4

High-throughput

0.628

High

1281265

TMED4
Transmembrane emp24 domain-containing protein 4

2

3

High-throughput

0.628

High

1330731

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

1388043

TRI44
Tripartite motif-containing protein 44

2

0

High-throughput

0.602

High

985284

RL10A
Large ribosomal subunit protein uL1

1

0

Small-scale

0.586

High

761822

HSP74
Heat shock 70 kDa protein 4

2

1

Small-scale

0.584

High

1394816

ALK
ALK tyrosine kinase receptor

2

6

High-throughput

0.584

High

1291659

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

0

High-throughput

0.576

High

396718

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1394803

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.565

High

242599

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

951355

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

1028340

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.559

High

167523

TX1B3
Tax1-binding protein 3

1

0

Small-scale

0.549

High

1146606

TMED2
Transmembrane emp24 domain-containing protein 2

1

5

High-throughput

0.536

High

1153427

CD226
CD226 antigen

1

4

High-throughput

0.536

High

1394789

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.536

High

1394790

TMPSD
Transmembrane protease serine 13

1

3

High-throughput

0.536

High

1394819

TMED5
Transmembrane emp24 domain-containing protein 5

1

5

High-throughput

0.536

High

415788

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

1123216

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.518

High

274706

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

470329

NEP
Neprilysin

1

0

Small-scale

0.513

High

682578

S100P
Protein S100-P

1

0

High-throughput

0.513

High

854227

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

1152203

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1231418

ZN787
Zinc finger protein 787

1

0

High-throughput

0.513

High

1235971

B4GN3
Beta-1,4-N-acetylgalactosaminyltransferase 3

1

0

High-throughput

0.513

High

1251102

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

0

High-throughput

0.513

High

1310315

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1381326

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1381465

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

1382148

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1394793

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

1394800

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.513

High

1394826

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

High-throughput

0.513

High

477254

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

6

High-throughput

0.500

High

298541

SPF30
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.493

High

643027

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.493

High

717573

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.493

High

827246

ARL1
ADP-ribosylation factor-like protein 1

1

0

High-throughput

0.493

High

893020

KHK
Ketohexokinase

1

0

High-throughput

0.493

High

1045645

TF65
Transcription factor p65

1

0

Small-scale

0.493

High

1153089

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

High-throughput

0.481

High

1142254

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

Small-scale

0.480

High

189776

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

355018

CHK2
Serine/threonine-protein kinase Chk2

1

1

Small-scale

0.479

High

363717

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

411003

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

5

High-throughput

0.479

High

439822

INSR
Insulin receptor

1

7

High-throughput

0.479

High

465617

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.479

High

484203

PGFRB
Platelet-derived growth factor receptor beta

1

3

High-throughput

0.479

High

541640

FGFR1
Fibroblast growth factor receptor 1

1

5

High-throughput

0.479

High

577859

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

604155

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630608

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.479

High

631412

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

774559

BASI
Basigin

1

1

High-throughput

0.479

High

777746

VGFR3
Vascular endothelial growth factor receptor 3

1

4

High-throughput

0.479

High

901489

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.479

High

902005

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

1087243

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1125606

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1157031

NTRK3
NT-3 growth factor receptor

1

6

High-throughput

0.479

High

1227264

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1287412

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1294235

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

1334512

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1367025

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1394785

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1394794

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

1394804

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

1394815

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

822818

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

911054

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

1387392

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.460

High

163153

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

174047

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

186217

PPM1D
Protein phosphatase 1D

1

0

Small-scale

0.458

High

285710

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.458

High

291488

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

391067

TRFL
Lactotransferrin

1

0

High-throughput

0.458

High

417679

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418359

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

447319

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

488839

FURIN
Furin

1

0

High-throughput

0.458

High

508445

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

537714

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

540623

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

611292

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

634579

LMNB1
Lamin-B1

1

0

High-throughput

0.458

High

655888

TBG1
Tubulin gamma-1 chain

1

0

Small-scale

0.458

High

658343

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

693056

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

696223

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

699011

CALX
Calnexin

1

0

High-throughput

0.458

High

837789

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

847646

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

894974

EMD
Emerin

1

0

High-throughput

0.458

High

904069

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

962385

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

976485

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

1004163

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1032394

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.458

High

1058592

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1100241

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1106661

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1111661

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1152592

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

1158159

MK14
Mitogen-activated protein kinase 14

1

0

Small-scale

0.458

High

1255084

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1280413

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.458

High

1333951

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1336821

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1383011

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1394786

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1394787

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1394788

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1394791

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1394792

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

1394795

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1394797

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

0

High-throughput

0.458

High

1394799

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1394801

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1394802

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1394805

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1394806

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1394807

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1394809

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1394810

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1394811

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

0

High-throughput

0.458

High

1394812

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

1394814

WWC3
Protein WWC3

1

0

High-throughput

0.458

High

1394821

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

1394822

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

188966

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.437

High

379697

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.437

High

464033

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

5

High-throughput

0.437

High

630933

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

710746

EPHA8
Ephrin type-A receptor 8

1

2

High-throughput

0.437

High

931880

EPHA5
Ephrin type-A receptor 5

1

3

High-throughput

0.437

High

1034320

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

5

High-throughput

0.437

High

1235315

STYK1
Tyrosine-protein kinase STYK1

1

3

High-throughput

0.437

High

1286868

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1322947

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1360915

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

171557

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

278937

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.426

High

469175

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.426

High

582396

B4GT1
Beta-1,4-galactosyltransferase 1

1

0

High-throughput

0.426

High

638137

AOFA
Amine oxidase [flavin-containing] A

1

0

High-throughput

0.426

High

683315

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.426

High

1110535

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.426

High

1357936

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.426

High

1366176

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

1394796

GO45
Golgin-45

1

0

High-throughput

0.426

High

1394817

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

1394823

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

High-throughput

0.426

High

1394825

NPTN
Neuroplastin

1

1

High-throughput

0.407

High

1326566

PP4P2
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

4

0

Small-scale

0.360

High

1394798

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

322161

GLCE
D-glucuronyl C5-epimerase

2

0

High-throughput

0.313

High

914326

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1158823

CART

1

0

High-throughput

0.279

Low

1249537

AMTN
Amelotin

1

0

High-throughput

0.279

Low

1294667

XYLT1
Xylosyltransferase 1

1

0

High-throughput

0.279

Low

1339976

OR6T1
Olfactory receptor 6T1

1

0

High-throughput

0.279

Low

1394818

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.279

Low

106464

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

379129

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.249

Low

767485

RADI
Radixin

1

0

High-throughput

0.249

Low

937521

CADH4
Cadherin-4

1

0

Small-scale

0.249

Low

1027137

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1341062

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

Small-scale

0.249

Low

466951

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

1185893

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025