Protein: ESCO2
N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)

Gene: ESCO2
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q56NI9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001741 - XY body
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0004468 - L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

899948

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.580

High

1063307

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.580

High

1201257

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

888113

MCM2
DNA replication licensing factor MCM2

1

7

Small-scale

0.573

High

1128215

MCM6
DNA replication licensing factor MCM6

1

7

Small-scale

0.573

High

755948

MCM5
DNA replication licensing factor MCM5

1

7

Small-scale

0.561

High

756230

MCM7
DNA replication licensing factor MCM7

1

6

Small-scale

0.561

High

1201261

RCOR1
REST corepressor 1

2

0

Small-scale

0.559

High

755729

MCM4
DNA replication licensing factor MCM4

1

6

Small-scale

0.552

High

1201244

MMS22
Protein MMS22-like

1

0

Small-scale

0.537

High

1201254

H2AJ
Histone H2A.J

1

1

High-throughput

0.536

High

1201256

CBX8
Chromobox protein homolog 8

1

3

High-throughput

0.536

High

163955

NDC80
Kinetochore protein NDC80 homolog

1

0

High-throughput

0.513

High

340341

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.513

High

648365

USF1
Upstream stimulatory factor 1

1

0

High-throughput

0.513

High

686820

S10A4
Protein S100-A4

1

0

High-throughput

0.513

High

841187

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.513

High

846331

MATR3
Matrin-3

1

0

High-throughput

0.513

High

948535

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1117564

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

1201247

ZN677
Zinc finger protein 677

1

0

High-throughput

0.513

High

1201258

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.513

High

551080

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.501

High

1201263

SMC3
Structural maintenance of chromosomes protein 3

1

1

Small-scale

0.501

High

216451

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.479

High

246645

KDM1A
Lysine-specific histone demethylase 1A

1

1

Small-scale

0.479

High

277712

H2AY
Core histone macro-H2A.1

1

3

Small-scale

0.479

High

331030

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

669917

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.479

High

940986

HDAC4
Histone deacetylase 4

1

4

Small-scale

0.479

High

980819

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

998398

H31
Histone H3.1

1

1

Small-scale

0.479

High

1109788

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

1114866

CUL4A
Cullin-4A

1

1

Small-scale

0.479

High

1115236

CUL4B
Cullin-4B

1

1

Small-scale

0.479

High

1139726

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

Small-scale

0.479

High

1201242

H2A2A
Histone H2A type 2-A

1

1

Small-scale

0.479

High

1201250

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.479

High

1201253

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

3

Small-scale

0.479

High

1201259

H2AW
Core histone macro-H2A.2

1

3

Small-scale

0.479

High

223102

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

281216

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.458

High

400939

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

447086

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

851585

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

854866

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

986464

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1045363

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1140378

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1157748

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1158866

RBBP7
Histone-binding protein RBBP7

1

0

Small-scale

0.458

High

1201240

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

Small-scale

0.458

High

1201246

MCM10
Protein MCM10 homolog

1

0

Small-scale

0.458

High

1201249

H1X
Histone H1.10

1

0

Small-scale

0.458

High

1201251

PF21A
PHD finger protein 21A

1

0

Small-scale

0.458

High

1201260

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1201264

DCAF1
DDB1- and CUL4-associated factor 1

1

0

Small-scale

0.458

High

191664

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.426

High

208275

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

1009215

PRR3
Proline-rich protein 3

1

0

High-throughput

0.426

High

1037184

H11
Histone H1.1

1

0

High-throughput

0.426

High

1136789

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.426

High

1201243

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1201262

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

1144822

RABE1
Rab GTPase-binding effector protein 1

2

0

High-throughput

0.316

High

1201241

FTM
Protein fantom

2

0

High-throughput

0.298

High

169185

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

190376

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

774153

ADDB
Beta-adducin

1

0

High-throughput

0.279

Low

1051766

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.279

Low

1196234

GAG2E
G antigen 2E

1

0

High-throughput

0.279

Low

1201245

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

1201248

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1201252

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1201255

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025