Protein: PEN2
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)

Gene: PEN2, PSENEN
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9NZ42

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890062

PSN1
Presenilin-1

10

7

Small-scale

0.971

High

1364065

NICA
Nicastrin

6

3

Small-scale

0.931

High

890780

PSN2
Presenilin-2

3

7

Small-scale

0.827

High

1384650

APH1A
Gamma-secretase subunit APH-1A

7

3

Small-scale

0.740

High

1090037

NTCP2
Ileal sodium/bile acid cotransporter

2

1

High-throughput

0.606

High

1186062

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.606

High

1414233

CRUM3
Protein crumbs homolog 3

2

0

High-throughput

0.580

High

875808

PRC2A
Protein PRRC2A

1

2

High-throughput

0.536

High

1058950

ZO1
Tight junction protein 1

1

1

High-throughput

0.536

High

1353290

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.536

High

1365859

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

1

High-throughput

0.536

High

1452958

ZO2
Tight junction protein 2

1

1

High-throughput

0.536

High

451676

TRBM
Thrombomodulin

1

0

High-throughput

0.518

High

230579

KIF1C
Kinesin-like protein KIF1C

1

0

High-throughput

0.513

High

270986

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.513

High

889349

NUMB
Protein numb homolog

1

0

High-throughput

0.513

High

1111322

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1201258

ESCO2
N-acetyltransferase ESCO2

1

0

High-throughput

0.513

High

1288277

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1288986

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.513

High

1327470

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.513

High

1361325

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.513

High

1419712

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.513

High

1429578

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.513

High

889026

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

Small-scale

0.500

High

423331

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

440758

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

1149065

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

238963

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

1

High-throughput

0.489

High

326385

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.489

High

1121754

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.489

High

1206558

PRC2B
Protein PRRC2B

1

1

High-throughput

0.489

High

1217847

PR38B
Pre-mRNA-splicing factor 38B

1

1

High-throughput

0.489

High

1413323

DIDO1
Death-inducer obliterator 1

1

1

High-throughput

0.489

High

1451201

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.489

High

230450

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.486

High

391498

FRIL
Ferritin light chain

1

0

Small-scale

0.484

High

321371

ERLN2
Erlin-2

1

1

Small-scale

0.479

High

1359069

APH1B
Gamma-secretase subunit APH-1B

1

3

Small-scale

0.479

High

61868

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.437

High

256179

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

244779

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

1451160

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.279

Low

1452681

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.279

Low

1452957

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.279

Low

1452959

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.279

Low

1452960

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.279

Low

1452961

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.279

Low

1452962

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.279

Low

1452963

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.279

Low

352570

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.279

Low

569143

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

594860

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.279

Low

636156

CD11B
Cyclin-dependent kinase 11B

1

0

High-throughput

0.279

Low

770434

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

935643

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.279

Low

1032431

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.279

Low

1104997

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.279

Low

1124427

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

1124558

MAP7
Ensconsin

1

0

High-throughput

0.279

Low

1193667

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.279

Low

1207454

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.279

Low

1208818

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.279

Low

1212052

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.279

Low

1214678

RBM26
RNA-binding protein 26

1

0

High-throughput

0.279

Low

1218828

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

1229721

VIR
Protein virilizer homolog

1

0

High-throughput

0.279

Low

1258754

F10C1
Protein FRA10AC1

1

0

High-throughput

0.279

Low

1270795

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.279

Low

1272126

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1293363

ERIC1
Glutamate-rich protein 1

1

0

High-throughput

0.279

Low

1332855

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.279

Low

1336762

RB15B
Putative RNA-binding protein 15B

1

0

High-throughput

0.279

Low

1346961

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.279

Low

1358211

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1388548

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

1389741

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1399772

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

1405505

SCAFB
Protein SCAF11

1

0

High-throughput

0.279

Low

1430029

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.279

Low

1434459

ESF1
ESF1 homolog

1

0

High-throughput

0.279

Low

1449402

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

1450205

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.279

Low

251321

NEMF
Ribosome quality control complex subunit NEMF

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025