Protein: MCM10
Protein MCM10 homolog (HsMCM10)

Gene: MCM10
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q7L590

Gene Ontology (top 5):
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1128228

MCM6
DNA replication licensing factor MCM6

7

14

High-throughput

0.753

High

756249

MCM7
DNA replication licensing factor MCM7

3

14

High-throughput

0.667

High

755744

MCM4
DNA replication licensing factor MCM4

3

12

High-throughput

0.667

High

1272232

MCM10
Protein MCM10 homolog

1

3

Small-scale

0.666

High

1104353

ORC2
Origin recognition complex subunit 2

2

3

Small-scale

0.650

High

422421

A4
Amyloid-beta precursor protein

3

0

High-throughput

0.642

High

1272255

MCMBP
Mini-chromosome maintenance complex-binding protein

3

0

High-throughput

0.638

High

1272278

TX264
Testis-expressed protein 264

3

0

High-throughput

0.638

High

315725

RECQ4
ATP-dependent DNA helicase Q4

2

1

Small-scale

0.624

High

1143378

PCM1
Pericentriolar material 1 protein

3

0

High-throughput

0.616

High

372401

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.613

High

718894

CCND3
G1/S-specific cyclin-D3

2

1

High-throughput

0.611

High

323452

TRI37
E3 ubiquitin-protein ligase TRIM37

2

0

High-throughput

0.605

High

1272260

IKZF5
Zinc finger protein Pegasus

2

0

High-throughput

0.602

High

1272276

DCAF1
DDB1- and CUL4-associated factor 1

2

0

Small-scale

0.598

High

1272272

PNMA2
Paraneoplastic antigen Ma2

2

0

High-throughput

0.576

High

1157784

DDB1
DNA damage-binding protein 1

2

0

Small-scale

0.559

High

1272247

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

1

High-throughput

0.541

High

1272279

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.537

High

132490

CDC7
Cell division cycle 7-related protein kinase

1

2

High-throughput

0.536

High

231495

ORC4
Origin recognition complex subunit 4

1

4

High-throughput

0.536

High

281223

CDC45
Cell division control protein 45 homolog

1

2

High-throughput

0.536

High

664769

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.536

High

669930

MCM3
DNA replication licensing factor MCM3

1

15

High-throughput

0.536

High

842793

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.536

High

888152

MCM2
DNA replication licensing factor MCM2

1

13

High-throughput

0.536

High

1025377

CDK6
Cyclin-dependent kinase 6

1

1

High-throughput

0.536

High

1272252

CDC6
Cell division control protein 6 homolog

1

4

High-throughput

0.536

High

1272268

ORC3
Origin recognition complex subunit 3

1

1

High-throughput

0.536

High

659518

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.536

High

848663

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

212846

ZBT43
Zinc finger and BTB domain-containing protein 43

1

0

High-throughput

0.518

High

618058

K1C15
Keratin, type I cytoskeletal 15

1

0

High-throughput

0.518

High

1095682

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.518

High

1154529

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1272233

DPPA2
Developmental pluripotency-associated protein 2

1

0

High-throughput

0.518

High

808105

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.513

High

920468

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

1272251

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

130524

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.513

High

625461

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

948548

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

960777

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

976108

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

979884

H4
Histone H4

1

0

High-throughput

0.513

High

1036660

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

0

High-throughput

0.513

High

1095896

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.513

High

1117584

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

1232686

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.513

High

1272245

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.513

High

1272246

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

1137813

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.486

High

971701

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.480

High

290055

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

341606

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

883592

CENPA
Histone H3-like centromeric protein A

1

3

High-throughput

0.479

High

946818

H2B1D
Histone H2B type 1-D

1

1

High-throughput

0.479

High

980875

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

984832

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

1016977

H33
Histone H3.3

1

3

High-throughput

0.479

High

1122744

DPOA2
DNA polymerase alpha subunit B

1

2

High-throughput

0.479

High

1130902

PSF1
DNA replication complex GINS protein PSF1

1

2

Small-scale

0.479

High

1272238

FANCM
Fanconi anemia group M protein

1

1

Small-scale

0.479

High

140981

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

714220

PML
Protein PML

1

0

High-throughput

0.458

High

799236

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

978113

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

983860

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1045439

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1114914

CUL4A
Cullin-4A

1

0

Small-scale

0.458

High

1158894

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.458

High

1201246

ESCO2
N-acetyltransferase ESCO2

1

0

Small-scale

0.458

High

1272234

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.458

High

1272235

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1272237

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1272250

NEB2
Neurabin-2

1

0

High-throughput

0.458

High

1272257

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

1272258

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

1272265

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1272269

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1272271

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1193434

CCD14
Coiled-coil domain-containing protein 14

1

1

High-throughput

0.437

High

1063968

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.426

High

1198582

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1239857

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1272236

FBX11
F-box only protein 11

1

0

High-throughput

0.426

High

1272256

ZN692
Zinc finger protein 692

1

0

High-throughput

0.426

High

1272266

DONS
Protein downstream neighbor of Son

1

0

Small-scale

0.426

High

1180395

KLH40
Kelch-like protein 40

4

0

High-throughput

0.364

High

1272244

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

607895

TPH1
Tryptophan 5-hydroxylase 1

2

0

High-throughput

0.328

High

941358

CAV3
Caveolin-3

2

0

High-throughput

0.328

High

1272241

RELL2
RELT-like protein 2

2

0

High-throughput

0.328

High

1272270

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

0

High-throughput

0.328

High

1272275

NINL
Ninein-like protein

2

0

High-throughput

0.320

High

1252879

BAKOR
Beclin 1-associated autophagy-related key regulator

2

0

High-throughput

0.318

High

1272267

CEP72
Centrosomal protein of 72 kDa

2

0

High-throughput

0.317

High

1272254

UBAC1
Ubiquitin-associated domain-containing protein 1

2

0

High-throughput

0.316

High

1272261

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

391312

FRIL
Ferritin light chain

2

0

High-throughput

0.313

High

1063371

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.299

High

1272243

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.282

High

1272248

HOOK2
Protein Hook homolog 2

1

0

High-throughput

0.282

High

155203

NCKP5
Nck-associated protein 5

1

0

High-throughput

0.279

Low

190409

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

215588

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.279

Low

257642

PRAF2
PRA1 family protein 2

1

0

High-throughput

0.279

Low

630305

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

698312

MAP4
Microtubule-associated protein 4

1

0

High-throughput

0.279

Low

706184

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

1177158

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.279

Low

1216371

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1272249

TMM74
Transmembrane protein 74

1

0

High-throughput

0.279

Low

1272262

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1272263

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

1272277

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

106169

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

412153

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1144979

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.249

Low

1272240

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

1272253

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.249

Low

1272259

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1272264

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.249

Low

1272273

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1272274

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.249

Low

58847

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

1155070

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1272239

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.232

Low

1272242

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025