Protein: GDF15
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)

Gene: GDF15
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q99988

Gene Ontology (top 5):
GO:0002023 - reduction of food intake in response to dietary excess
GO:0002686 - negative regulation of leukocyte migration
GO:0005125 - cytokine activity
GO:0005179 - hormone activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1408505

GDF15
Growth/differentiation factor 15

3

16

Small-scale

0.834

High

1250089

GFRAL
GDNF family receptor alpha-like

1

1

Small-scale

0.692

High

164776

GDF8
Growth/differentiation factor 8

1

16

High-throughput

0.691

High

282860

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.691

High

1360038

OIT3
Oncoprotein-induced transcript 3 protein

1

16

High-throughput

0.691

High

1366663

SORL
Sortilin-related receptor

1

2

High-throughput

0.691

High

1401923

ERBIN
Erbin

1

1

High-throughput

0.691

High

1157046

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.646

High

1407062

MDFI
MyoD family inhibitor

3

0

High-throughput

0.643

High

885381

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.606

High

1408519

TACC3
Transforming acidic coiled-coil-containing protein 3

2

2

High-throughput

0.606

High

1359231

CA054
Uncharacterized protein C1orf54

2

6

High-throughput

0.601

High

1408511

RMD5A
E3 ubiquitin-protein transferase RMND5A

2

6

High-throughput

0.601

High

1097520

CBX3
Chromobox protein homolog 3

2

0

High-throughput

0.580

High

436724

KPCB
Protein kinase C beta type

2

1

High-throughput

0.571

High

1143090

KPCD1
Serine/threonine-protein kinase D1

2

2

High-throughput

0.571

High

948377

KR122
Keratin-associated protein 12-2

2

14

High-throughput

0.553

High

216797

HTRA2
Serine protease HTRA2, mitochondrial

1

6

High-throughput

0.536

High

224515

PI15
Peptidase inhibitor 15

1

1

High-throughput

0.536

High

342653

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

476532

CEL3B
Chymotrypsin-like elastase family member 3B

1

4

High-throughput

0.536

High

506898

CFC1
Cryptic protein

1

12

High-throughput

0.536

High

535457

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.536

High

567966

PRG2
Bone marrow proteoglycan

1

6

High-throughput

0.536

High

593480

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.536

High

608340

EGLN
Endoglin

1

9

High-throughput

0.536

High

702410

CYTD
Cystatin-D

1

2

High-throughput

0.536

High

838388

STA5A
Signal transducer and activator of transcription 5A

1

1

High-throughput

0.536

High

933218

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.536

High

1030209

IL5RA
Interleukin-5 receptor subunit alpha

1

5

High-throughput

0.536

High

1085374

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

7

High-throughput

0.536

High

1116288

PTC1
Protein patched homolog 1

1

3

High-throughput

0.536

High

1250512

RBP10
Ran-binding protein 10

1

8

High-throughput

0.536

High

1272733

MAEA
E3 ubiquitin-protein transferase MAEA

1

7

High-throughput

0.536

High

1331944

TM102
Transmembrane protein 102

1

1

High-throughput

0.536

High

1382046

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

1391434

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.536

High

1400860

RAB3I
Rab-3A-interacting protein

1

2

High-throughput

0.536

High

1402280

RANB9
Ran-binding protein 9

1

8

High-throughput

0.536

High

1408510

WDR26
WD repeat-containing protein 26

1

7

High-throughput

0.536

High

1408513

GID8
Glucose-induced degradation protein 8 homolog

1

7

High-throughput

0.536

High

1408517

MKLN1
Muskelin

1

1

High-throughput

0.536

High

1408518

PRG3
Proteoglycan 3

1

7

High-throughput

0.536

High

369082

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

414505

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

977154

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.513

High

1058235

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

1121648

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.513

High

1307911

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

1388487

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.513

High

1408512

SETD4
SET domain-containing protein 4

1

0

High-throughput

0.513

High

1408515

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.513

High

1408516

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.513

High

1408506

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.489

High

1158169

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.486

High

401373

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

520329

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

965191

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

1024797

VIGLN
Vigilin

1

2

High-throughput

0.479

High

1108089

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1358098

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1408514

NLGN3
Neuroligin-3

1

1

Small-scale

0.464

High

590935

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

1408507

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

73849

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

14

High-throughput

0.445

High

1047713

NOTC2
Neurogenic locus notch homolog protein 2

1

10

High-throughput

0.445

High

1034517

TAGL
Transgelin

1

0

High-throughput

0.426

High

1358836

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.426

High

66656

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

724169

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

1309304

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.279

Low

1328266

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.279

Low

1404305

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

1408508

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.279

Low

1408509

DPEP2
Dipeptidase 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025